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Mostrando 281 - 300 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.17s Limitar resultados
  1. 281
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    Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core
  2. 282
    “…OBJECTIVE(S): Lysine-specific demethylase1 (LSD1), an important class of histone demethylases, plays a crucial role in regulation of mammalian biology. …”
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    Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration
  3. 283
    “…This review will provide insight into the overview structure of LSD1, summarize its action mechanisms in BC, describe the therapeutic potential of LSD1 inhibitors in BC, and prospect the current opportunities and challenges of targeting LSD1 for BC therapy.…”
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    A state-of-the-art review on LSD1 and its inhibitors in breast cancer: Molecular mechanisms and therapeutic significance
  4. 284
    “…Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. …”
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    Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape
  5. 285
    “…An abnormal level of histone methylation is a crucial characteristic of metastatic cancer cells. LSD1 is a histone demethylase. We found that T-96 could significantly decrease the protein expression of LSD1, increase its target protein PTEN expression and enhance histone methylation. …”
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    Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms
  6. 286
    “…Demethylase enzymatic activity of lysine-specific demethylase 1 (LSD1), a histone demethylase first identified in 2004, plays a pivotal role in the vast cellular processes of cancer. …”
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    Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast Cancers
  7. 287
    “…However, the biological function of the lysine-specific histone demethylase 1B (LSD2/KDM1B) in CRC is not well understood. Therefore, we investigated the characteristics of LSD2 in CRC. …”
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    Lysine-specific histone demethylase 1B (LSD2/KDM1B) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through LSD2-mediated H3K4me2 demethylation
  8. 288
    “…In our recently published phase 1 study in healthy volunteers [4], we determined that LSD microdosing was relatively safe and well tolerated in that cohort. …”
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    An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)
  9. 289
    “…BACKGROUND: Lysine-specific demethylase 1 (LSD1), catalysing demethylation of mono- and di-methylated histone H3-K4 or K9, exhibits diverse transcriptional activities by mediating chromatin reconfiguration. …”
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    Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene
  10. 290
    “…However, its regulatory mechanism is poorly understood. AtLSD1 is an important negative regulator of PCD and only two proteins, AtbZIP10 and AtMC1, have been reported to interact with AtLSD1. …”
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    The LSD1-Interacting Protein GILP Is a LITAF Domain Protein That Negatively Regulates Hypersensitive Cell Death in Arabidopsis
  11. 291
    “…Accordingly, Meis1 was significantly upregulated in LSD1 inhibited erythroid cells, but not in megakaryocytes. …”
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    Differential Transcriptional Regulation of meis1 by Gfi1b and Its Co-Factors LSD1 and CoREST
  12. 292
    “…Here, we show that LSD1 physically binds MYCN both in vitro and in vivo and that such an interaction requires the MYCN BoxIII. …”
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    Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
  13. 293
    “…Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development. KDM1A deficiency results in developmental arrest by the two-cell stage, accompanied by dramatic and stepwise alterations in H3K9 and H3K4 methylation patterns. …”
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    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation
  14. 294
    “…This suggests that LSD1/KDM1A maternal reprogramming is conserved. …”
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    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally
  15. 295
    “…The C-terminal SAP motif of KU70 mediates LSD1/SIRT1 competitive interaction by suppressing LSD1 binding to KU70 and ectopic expression of SAP-deleted KU70 to CML cells compromises their ability to acquire BCR-ABL mutations. …”
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    SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
  16. 296
    “…In NB tissues, high levels of LSD1 correlate with low levels of NDRG1 and reduced patients survival. …”
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    LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene
  17. 297
    “…Aberrant activation of histone lysine-specific demethylase (LSD1) increases tumorigenicity; hence, LSD1 is considered a therapeutic target for various human cancers. …”
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    Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models
  18. 298
    “…Together, our results reveal a novel link between NR2E3, AHR, and liver cancer via LSD1-mediated H3K4me2 histone modification in liver cancer development.…”
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    Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer
  19. 299
    “…The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. …”
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    LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth
  20. 300
    “…The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. …”
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    Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation
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