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282por Qin, Ting-ting, Li, Zhong-hua, Li, Li-xin, Du, Kun, Yang, Ji-ge, Zhang, Zhen-qiang, Wu, Xiang-xiang, Ma, Jin-lian“…OBJECTIVE(S): Lysine-specific demethylase1 (LSD1), an important class of histone demethylases, plays a crucial role in regulation of mammalian biology. …”
Publicado 2022
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283por Yang, Guan-Jun, Liu, Yan-Jun, Ding, Li-Jian, Tao, Fan, Zhu, Ming-Hui, Shi, Zhen-Yuan, Wen, Juan-Ming, Niu, Meng-Yao, Li, Xiang, Xu, Zhan-Song, Qin, Wan-Jia, Fei, Chen-Jie, Chen, Jiong“…This review will provide insight into the overview structure of LSD1, summarize its action mechanisms in BC, describe the therapeutic potential of LSD1 inhibitors in BC, and prospect the current opportunities and challenges of targeting LSD1 for BC therapy.…”
Publicado 2022
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284por Singleton, S. Parker, Luppi, Andrea I., Carhart-Harris, Robin L., Cruzat, Josephine, Roseman, Leor, Nutt, David J., Deco, Gustavo, Kringelbach, Morten L., Stamatakis, Emmanuel A., Kuceyeski, Amy“…Psychedelics including lysergic acid diethylamide (LSD) and psilocybin temporarily alter subjective experience through their neurochemical effects. …”
Publicado 2022
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285por Shen, Zhengjie, Gu, Yongjuan, Jiang, Ruiyang, Qian, Heya, Li, Siyuan, Xu, Lixian, Gu, Wenzhe, Zuo, Yun“…An abnormal level of histone methylation is a crucial characteristic of metastatic cancer cells. LSD1 is a histone demethylase. We found that T-96 could significantly decrease the protein expression of LSD1, increase its target protein PTEN expression and enhance histone methylation. …”
Publicado 2022
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286“…Demethylase enzymatic activity of lysine-specific demethylase 1 (LSD1), a histone demethylase first identified in 2004, plays a pivotal role in the vast cellular processes of cancer. …”
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287“…However, the biological function of the lysine-specific histone demethylase 1B (LSD2/KDM1B) in CRC is not well understood. Therefore, we investigated the characteristics of LSD2 in CRC. …”
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288por Donegan, Carina Joy, Daldegan-Bueno, Dimitri, Sumner, Rachael, Menkes, David, Evans, William, Hoeh, Nicholas, Sundram, Frederick, Reynolds, Lisa, Ponton, Rhys, Cavadino, Alana, Smith, Todd, Roop, Partha, Allen, Nathan, Abeysinghe, Binu, Svirskis, Darren, Forsyth, Anna, Bansal, Mahima, Muthukumaraswamy, Suresh“…In our recently published phase 1 study in healthy volunteers [4], we determined that LSD microdosing was relatively safe and well tolerated in that cohort. …”
Publicado 2023
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289por Zhu, Qingjun, Liu, Cheng, Ge, Zheng, Fang, Xiaolei, Zhang, Xi, Strååt, Klas, Björkholm, Magnus, Xu, Dawei“…BACKGROUND: Lysine-specific demethylase 1 (LSD1), catalysing demethylation of mono- and di-methylated histone H3-K4 or K9, exhibits diverse transcriptional activities by mediating chromatin reconfiguration. …”
Publicado 2008
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290por He, Shanping, Tan, Guihong, Liu, Qian, Huang, Kuowei, Ren, Jiao, Zhang, Xu, Yu, Xiangchun, Huang, Ping, An, Chengcai“…However, its regulatory mechanism is poorly understood. AtLSD1 is an important negative regulator of PCD and only two proteins, AtbZIP10 and AtMC1, have been reported to interact with AtLSD1. …”
Publicado 2011
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291por Chowdhury, Asif H., Ramroop, Johnny R., Upadhyay, Ghanshyam, Sengupta, Ananya, Andrzejczyk, Anna, Saleque, Shireen“…Accordingly, Meis1 was significantly upregulated in LSD1 inhibited erythroid cells, but not in megakaryocytes. …”
Publicado 2013
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292por Amente, Stefano, Milazzo, Giorgio, Sorrentino, Maria Cristina, Ambrosio, Susanna, Di Palo, Giacomo, Lania, Luigi, Perini, Giovanni, Majello, Barbara“…Here, we show that LSD1 physically binds MYCN both in vitro and in vivo and that such an interaction requires the MYCN BoxIII. …”
Publicado 2015
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293por Ancelin, Katia, Syx, Laurène, Borensztein, Maud, Ranisavljevic, Noémie, Vassilev, Ivaylo, Briseño-Roa, Luis, Liu, Tao, Metzger, Eric, Servant, Nicolas, Barillot, Emmanuel, Chen, Chong-Jian, Schüle, Roland, Heard, Edith“…Here, we explore the function of the oocyte-inherited pool of a histone H3K4 and K9 demethylase, LSD1/KDM1A during early mouse development. KDM1A deficiency results in developmental arrest by the two-cell stage, accompanied by dramatic and stepwise alterations in H3K9 and H3K4 methylation patterns. …”
Publicado 2016
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294por Wasson, Jadiel A, Simon, Ashley K, Myrick, Dexter A, Wolf, Gernot, Driscoll, Shawn, Pfaff, Samuel L, Macfarlan, Todd S, Katz, David J“…This suggests that LSD1/KDM1A maternal reprogramming is conserved. …”
Publicado 2016
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295“…The C-terminal SAP motif of KU70 mediates LSD1/SIRT1 competitive interaction by suppressing LSD1 binding to KU70 and ectopic expression of SAP-deleted KU70 to CML cells compromises their ability to acquire BCR-ABL mutations. …”
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296por Ambrosio, Susanna, Amente, Stefano, Saccà, Carmen D., Capasso, Mario, Calogero, Raffaele A., Lania, Luigi, Majello, Barbara“…In NB tissues, high levels of LSD1 correlate with low levels of NDRG1 and reduced patients survival. …”
Publicado 2016
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297por Yang, Cheng-Yu, Lin, Chih-Kung, Tsao, Chang-Huei, Hsieh, Cheng-Chih, Lin, Gu-Jiun, Ma, Kuo-Hsing, Shieh, Yi-Shing, Sytwu, Huey-Kang, Chen, Yuan-Wu“…Aberrant activation of histone lysine-specific demethylase (LSD1) increases tumorigenicity; hence, LSD1 is considered a therapeutic target for various human cancers. …”
Publicado 2017
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298Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancerpor Khanal, Tilak, Choi, Kwangmin, Leung, Yuet-Kin, Wang, Jiang, Kim, Dasom, Janakiram, Vinothini, Cho, Sung-Gook, Puga, Alvaro, Ho, Shuk-Mei, Kim, Kyounghyun“…Together, our results reveal a novel link between NR2E3, AHR, and liver cancer via LSD1-mediated H3K4me2 histone modification in liver cancer development.…”
Publicado 2017
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299“…The discovery of lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, dramatically revolutionized research in the field of epigenetics. …”
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300Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylationpor Shan, Jiaoyu, Zhao, Binbin, Shan, Zhao, Nie, Jia, Deng, Rong, Xiong, Rui, Tsun, Andy, Pan, Weiqi, Zhao, Hanzhi, Chen, Ling, Jin, Ying, Qian, Zhikang, Lui, Kawing, Liang, Rui, Li, Dan, Sun, Bing, Lavillette, Dimitri, Xu, Ke, Li, Bin“…The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. …”
Publicado 2017
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