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Abuso de drogas
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301por Cao, Kaixiang, Collings, Clayton K., Morgan, Marc A., Marshall, Stacy A., Rendleman, Emily J., Ozark, Patrick A., Smith, Edwin R., Shilatifard, Ali“…Thus, we define an opposing regulatory axis, wherein Lsd1 and associated co-repressors directly repress Mll4-activated gene targets. …”
Publicado 2018
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302por Sun, Jun, Ermann, Joerg, Niu, Ningning, Yan, Guang, Yang, Yang, Shi, Yujiang, Zou, Weiguo“…Knockdown of LSD1 promoted osteoblast differentiation of human mesenchymal stem cells (hMSCs) in vitro and mice lacking LSD1 in mesenchymal cells displayed increased bone mass secondary to accelerated osteoblast differentiation. …”
Publicado 2018
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303por Wu, Dan, Xu, Yetao, Zou, Yanfen, Zuo, Qing, Huang, Shiyun, Wang, Sailan, Lu, Xiyi, He, Xuezhi, Wang, Jing, Wang, Tianjun, Sun, Lizhou“…In particular, linc00473 inhibited the expression of tissue factor pathway inhibitor 2 (TFPI2) through binding to lysine-specific demethylase 1 (LSD1). These results indicate that linc00473 could be involved in the pathogenesis and development of PE and may be a candidate biomarker as well as therapeutic target for this disease.…”
Publicado 2018
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304por Doll, Sophia, Kriegmair, Maximilian C., Santos, Alberto, Wierer, Michael, Coscia, Fabian, Neil, Helen Michele, Porubsky, Stefan, Geyer, Philipp E., Mund, Andreas, Nuhn, Philipp, Mann, Matthias“…Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine‐specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and the target of active development efforts in oncology. …”
Publicado 2018
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305por Sarno, Federica, Papulino, Chiara, Franci, Gianluigi, Andersen, Jeanette H., Cautain, Bastien, Melardo, Colombina, Altucci, Lucia, Nebbioso, AngelaEnlace del recurso
Publicado 2018
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306por Macheleidt, Iris F., Dalvi, Priya S., Lim, So‐Young, Meemboor, Sonja, Meder, Lydia, Käsgen, Olivia, Müller, Marion, Kleemann, Karolin, Wang, Lingyu, Nürnberg, Peter, Rüsseler, Vanessa, Schäfer, Stephan C., Mahabir, Esther, Büttner, Reinhard, Odenthal, Margarete“…Lysine‐specific demethylase 1 (LSD1) is an epigenetic eraser that modifies histone 3 methylation status, and is highly overexpressed in LUAD. …”
Publicado 2018
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307por Zhu, Liangsong, Wang, Jianfeng, Kong, Wen, Huang, Jiwei, Dong, Baijun, Huang, Yiran, Xue, Wei, Zhang, Jin“…Histone lysine-specific demethylase 1 (LSD1) has been implicated in the disease progression of several types of solid tumors. …”
Publicado 2019
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308por Cuyàs, Elisabet, Gumuzio, Juan, Lozano-Sánchez, Jesús, Carreras, David, Verdura, Sara, Llorach-Parés, Laura, Sanchez-Martinez, Melchor, Selga, Elisabet, Pérez, Guillermo J., Scornik, Fabiana S., Brugada, Ramon, Bosch-Barrera, Joaquim, Segura-Carretero, Antonio, Martin, Ángel G., Encinar, José Antonio, Menendez, Javier A.“…At higher concentrations, oleacein was predicted to target the interaction of LSD1 with histone H3 and the LSD1 co-repressor (RCOR1/CoREST), likely disturbing the anchorage of LSD1 to chromatin. …”
Publicado 2019
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309por Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.“…The histone demethylase lysine-specific demethylase 1 (LSD1 or KDM1A) has emerged as a candidate therapeutic target in acute myeloid leukaemia (AML); tranylcypromine-derivative inhibitors induce loss of clonogenic activity and promote differentiation, in particular in the MLL-translocated molecular subtype of AML. …”
Publicado 2019
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310Publicado 2016“…The LSD1 mRNA and protein were detected by RQ-PCR and Western blot. …”
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311por Saniotis, ArthurEnlace del recurso
Publicado 2020
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312“…In addition, the LSD1/wild-type p53/miR-34a signaling axis was also involved in the regulation of CD47/PD-L1 expression by targeting the 3′ untranslated regions (3′UTRs) of CD47/PD-L1. …”
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313por Murphy, Robin J., Sumner, Rachael L., Evans, William, Menkes, David, Lambrecht, Ingo, Ponton, Rhys, Sundram, Frederick, Hoeh, Nicholas, Ram, Sanya, Reynolds, Lisa, Muthukumaraswamy, SureshEnlace del recurso
Publicado 2021
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314por Tu, Wen Juan, McCuaig, Robert D., Melino, Michelle, Rawle, Daniel J., Le, Thuy T., Yan, Kexin, Suhrbier, Andreas, Johnston, Rebecca L., Koufariotis, Lambros T., Waddell, Nicola, Cross, Emily M., Tsimbalyuk, Sofiya, Bain, Amanda, Ahern, Elizabeth, Collinson, Natasha, Phipps, Simon, Forwood, Jade K., Seddiki, Nabila, Rao, Sudha“…Here, we report a novel SARS-CoV-2 viral replication mechanism mediated by interactions between ACE2 and the epigenetic eraser enzyme LSD1, and its interplay with the nuclear shuttling importin pathway. …”
Publicado 2021
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315por Gong, Zhicheng, Li, Aicun, Ding, Jiancheng, Li, Qing, Zhang, Lei, Li, Yuanpei, Meng, Zhe, Chen, Fei, Huang, Jialiang, Zhou, Dawang, Hu, Ronggui, Ye, Jing, Liu, Wen, You, Han“…OTUD7B deficiency increases K63‐linked ubiquitination of LSD1, which disrupts LSD1/CoREST complex formation and targets LSD1 for p62‐mediated proteolysis. …”
Publicado 2021
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316por Li, Xuesen, Song, Liankun, Xu, Shan, Tippin, Matthew, Meng, Shuan, Xie, Jun, Uchio, Edward, Zi, Xiaolin“…Furthermore, the KRE and kavalactones showed a significant inhibition of LSD1 and MAO-A enzyme activities. CONCLUSION: Our results suggest that consumption of kava products through diet can delay prostate cancer development and progression and that kavalactones may be a new structure model for developing a potent dual inhibitor of LSD1 and MAO-A.…”
Publicado 2021
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317“…When emotional self-regulation, negative self-perception and structural dissociation had also begun to improve and trauma exposure was better tolerated, LSD was introduced to intensify and deepen the therapeutic process. …”
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318por Gill, Harinder“…In this review, the role of LSD1/KDM1A inhibition as a potential disease-modification strategy in patients with myelofibrosis is described and discussed.…”
Publicado 2022
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319por Hu, Rong, Hameed, Umar Farook Shahul, Sun, Xiang, Moorthy, Balakrishnan Shenbaga, Zhang, Wen, Jeffrey, Philip D., Zhou, Li, Ma, Xin, Chen, Fangjin, Pei, Jianfeng, Giri, Pankaj K., Mou, Yonggao, Swaminathan, Kunchithapadam, Yuan, Ping“…Using Amide Hydrogen/Deuterium Exchange and Mass Spectrometry (HDX‐MS) method, we identified four LSD1 peptides that may interact with NR2E1. One of the peptides, LSD1‐197‐211 that locates at the LSD1 SWIRM domain, strongly inhibited BTIC proliferation by promoting Pten expression through interfering NR2E1 and LSD1 function. …”
Publicado 2022
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320por Becker, Anna M, Klaiber, Aaron, Holze, Friederike, Istampoulouoglou, Ioanna, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Liechti, Matthias E“…BACKGROUND: Lysergic acid diethylamide (LSD) is currently being investigated in psychedelic-assisted therapy. …”
Publicado 2022
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