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Abuso de drogas
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22“…Recent epigenetic studies have identified the novel regulatory element LSD1, which controls the above parameters, and have provided new mechanistic possibilities for re-encoding the fate and function of adipocytes. …”
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23por Jotatsu, Takanobu, Yagishita, Shigehiro, Tajima, Ken, Takahashi, Fumiyuki, Mogushi, Kaoru, Hidayat, Moulid, Wirawan, Aditya, Ko, Ryo, Kanemaru, Ryota, Shimada, Naoko, Mitani, Keiko, Saito, Tsuyoshi, Takamochi, Kazuya, Suzuki, Kenji, Kohsaka, Shinji, Kojima, Shinya, Mukae, Hiroshi, Yatera, Kazuhiro, Takahashi, Kazuhisa“…Cells with high expression of LSD1+8a were resistant to CDDP and LSD1 inhibitor. …”
Publicado 2016
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25por Tu, Wen Juan, McCuaig, Robert D., Tan, Abel H. Y., Hardy, Kristine, Seddiki, Nabila, Ali, Sayed, Dahlstrom, Jane E., Bean, Elaine G., Dunn, Jenny, Forwood, Jade, Tsimbalyuk, Sofia, Smith, Kate, Yip, Desmond, Malik, Laeeq, Prasanna, Thiru, Milburn, Peter, Rao, Sudha“…Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast cancer stem cells. …”
Publicado 2020
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27“…OBJECTIVES: The main goal of our research was to investigate the effect of music, as a part of “setting,” on the brain states dynamics after lysergic acid diethylamide (LSD) intake. METHODS: We used an open dataset, where a group of 15 participants underwent two functional MRI scanning sessions under LSD and placebo influence. …”
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28por Li, Zhonghai, Zhao, Yi, Liu, Xiaochuan, Peng, Jinying, Guo, Hongwei, Luo, Jingchu“…This manuscript describes an update of the leaf senescence database (LSD) previously featured in the 2011 NAR Database Issue. …”
Publicado 2014
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30“…In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. …”
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31“…Our previous report described the discovery and biological activity of a potent, selective, orally bioavailable, irreversible inhibitor of Lysine Demethylase 1 (LSD1), GSK2879552. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) was sensitive to LSD1 inhibition. …”
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32por Christopher, Michael A., Myrick, Dexter A., Barwick, Benjamin G., Engstrom, Amanda K., Porter-Stransky, Kirsten A., Boss, Jeremy M., Weinshenker, David, Levey, Allan I., Katz, David J.“…To investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice. Loss of LSD1 leads to paralysis, along with widespread hippocampus and cortex neurodegeneration, and learning and memory defects. …”
Publicado 2017
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33por Bais, Manish V.Enlace del recurso
Publicado 2017
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34“…On the MS and DTS, ratings of mystical experiences significantly increased 1 and 12 months after LSD administration compared with the pre-LSD screening. …”
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36“…PURPOSE: The purpose of this study was to extend the current understanding of endogenous lysine-specific demethylase 1 (LSD1) expression spatially and temporally in the retina. …”
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37por Fang, Yuan, Yang, Chao, Yu, Zhiqiang, Li, Xiaochuan, Mu, Qingchun, Liao, Guochao, Yu, Bin“…Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. …”
Publicado 2021
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38“…The following pages reveal some of the connections between mental health, LSD and the wider setting, avoiding both ascension and declension narratives. …”
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39por Harancher, Mitchell R., Packard, Jessica E., Cowan, Shane P., DeLuca, Neal A., Dembowski, Jill A.“…Unlike previously investigated LSD1 inhibitors tranylcypromine (TCP) and OG-L002, which covalently attach to the LSD1 cofactor flavin adenine dinucleotide (FAD) to inhibit demethylase activity, SP-2509 has previously been shown to inhibit LSD1 protein-protein interactions. …”
Publicado 2020
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40por Luppi, Andrea I., Carhart-Harris, Robin L., Roseman, Leor, Pappas, Ioannis, Menon, David K., Stamatakis, Emmanuel A.“…Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, by connecting novel psychological phenomena with their neurobiological correlates. …”
Publicado 2021
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