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421por Shi, Xuefei, Ma, Chenhui, Zhu, Qingqing, Yuan, Dongmei, Sun, Ming, Gu, Xiaoling, Wu, Guannan, Lv, Tangfeng, Song, Yong“…Further mechanistic analyses indicated that the oncogenic activity of linc00673 is partially attributable to its repression of NCALD through association with the epigenetic repressor LSD1. Taken together, these findings suggested that linc00673 could play crucial role in NSCLC progression and might be a potential therapeutic target for patients with NSCLC.…”
Publicado 2016
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422“…BACKGROUND: S2101 is one of the most potent LSD1 inhibitors, which can inhibit ovarian cancer cells viability. …”
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423por Fang, Jianwu, Ying, Haiyan, Mao, Ting, Fang, Yanjia, Lu, Yuan, Wang, He, Zang, Irene, Wang, Zhaofu, Lin, Ying, Zhao, Mengxi, Luo, Xiao, Wang, Zongyao, Zhang, Yan, Zhang, Chao, Xiao, Wei, Wang, Yan, Tan, Wei, Chen, Zhui, Lu, Chris, Atadja, Peter, Li, En, Zhao, Kehao, Liu, Jianfeng, Gu, Justin“…LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. …”
Publicado 2017
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424“…Mechanically, AGAP2-AS1 could interact with EZH2 and LSD1, recruiting them to TFPI2 promoter region to inhibit its transcription. …”
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425“…The cell proliferation ability of LSD1 was observed by CCK-8 assay after downregulating expression of LSD1. …”
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426por Yang, Jiebin, Lian, Yikai, Yang, Renzhi, Lian, Yifan, Wu, Jingtong, Liu, Jingjing, Wang, Keming, Xu, Hongzhi“…What’s more, the biological function of LINC00460 was mediated, to certain extent, by the direct interaction with enhancer of zeste homolog 2 (EZH2) and lysine (K)-specific demethylase 1A (LSD1) proteins. Further analyses indicated that LINC00460 promoted GC proliferation at least partly through the downregulation of tumor suppressor-gene Cyclin G2 (CCNG2), which is mediated by EZH2 and LSD1. …”
Publicado 2020
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427por Jurič, Andreja, Zandona, Antonio, Lovaković, Blanka Tariba, Rašić, Dubravka, Pizent, Alica, Kozina, Goran, Katalinić, Maja, Vrdoljak, Ana Lucić, Karačonji, Irena Brčić“…Lysergic acid diethylamide (LSD) is a classic hallucinogen, widely abused for decades, while phencyclidine (PCP) has increased in popularity in recent years, especially among the adolescents. …”
Publicado 2021
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428por Xu, Yongtao, He, Zihao, Liu, Hongyi, Chen, Yifan, Gao, Yunlong, Zhang, Songjie, Wang, Meiting, Lu, Xiaoyuan, Wang, Chang, Zhao, Zongya, Liu, Yan, Zhao, Junqiang, Yu, Yi, Yang, Min“…Histone Lysine Specific Demethylase 1 (LSD1) is overexpressed in many cancers and becomes a new target for anticancer drugs. …”
Publicado 2020
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429“…Lysine-specific histone demethylase 1 (LSD-1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 and is highly overexpressed in different types of cancer. …”
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430por Casey, Mattie J., Call, Alexandra M., Thorpe, Annika V., Jette, Cicely A., Engel, Michael E., Stewart, Rodney A.“…Here, we analyze two independent zebrafish lsd1/kdm1a mutant lines and show Lsd1 is required to repress primitive hematopoietic stem cell gene expression. …”
Publicado 2022
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431por Prakasam, Ramachandran, Bonadiman, Angela, Andreotti, Roberta, Zuccaro, Emanuela, Dalfovo, Davide, Marchioretti, Caterina, Tripathy, Debasmita, Petris, Gianluca, Anderson, Eric N., Migazzi, Alice, Tosatto, Laura, Cereseto, Anna, Battaglioli, Elena, Sorarù, Gianni, Lim, Wooi Fang, Rinaldi, Carlo, Sambataro, Fabio, Pourshafie, Naemeh, Grunseich, Christopher, Romanel, Alessandro, Pandey, Udai Bhan, Contestabile, Andrea, Ronzitti, Giuseppe, Basso, Manuela, Pennuto, Maria“…LSD1 and PRMT6 cooperatively and synergistically transactivate androgen receptor, and their effect is enhanced by expanded polyQ. …”
Publicado 2023
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432por Xiong, Yujing, Wang, Enyin, Huang, Yan, Guo, Xiaoyi, Yu, Yiping, Du, Qingyun, Ding, Xiaoyan, Sun, Yingpu“…We also found that treating hESCs with the LSD1 inhibitor CBB1007 promotes the adipogenic differentiation of hESCs.…”
Publicado 2016
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433por Gregorio, Danilo De, Posa, Luca, Ochoa-Sanchez, Rafael, McLaughlin, Ryan, Maione, Sabatino, Comai, Stefano, Gobbi, GabriellaEnlace del recurso
Publicado 2016
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434por Wass, Maxi, Göllner, Stefanie, Besenbeck, Birgit, Schlenk, Richard F., Mundmann, Petra, Göthert, Joachim R., Noppeney, Richard, Schliemann, Christoph, Mikesch, Jan-Henrik, Lenz, Georg, Dugas, Martin, Wermke, Martin, Röllig, Christoph, Bornhäuser, Martin, Serve, Hubert, Platzbecker, Uwe, Foerster, Kathrin I., Burhenne, Jürgen, Haefeli, Walter E., Müller, Lutz P., Binder, Mascha, Pabst, Caroline, Müller-Tidow, Carsten“…Previously, we showed that ATRA in combination with Lysine-specific demethylase 1 (LSD1) inhibition by tranylcypromine (TCP) can induce myeloid differentiation in AML blasts. …”
Publicado 2020
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435por Soldi, Raffaella, Ghosh Halder, Tithi, Weston, Alexis, Thode, Trason, Drenner, Kevin, Lewis, Rhonda, Kaadige, Mohan R., Srivastava, Shreyesi, Daniel Ampanattu, Sherin, Rodriguez del Villar, Ryan, Lang, Jessica, Vankayalapati, Hariprasad, Weissman, Bernard, Trent, Jeffrey M., Hendricks, William P. D., Sharma, Sunil“…SCCOHT and OCCC cell lines have shown sensitivity to the reversible LSD1 inhibitor SP-2577 (Seclidemstat), suggesting that SWI/SNF-deficient ovarian cancers are dependent on LSD1 activity. …”
Publicado 2020
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436por Lian, Yifan, Yan, Changsheng, Lian, Yikai, Yang, Renzhi, Chen, Qiongyun, Ma, Dan, Lian, Weibin, Liu, Jingjing, Luo, Chengyan, Ren, Jianlin, Xu, Hongzhi“…Mechanistically, LINC01446 could widely interact with histone lysine-specific demethylase LSD1 and recruit LSD1 to the Ras-related dexamethasone-induced 1 (RASD1) promoter, thereby suppressing RASD1 transcription. …”
Publicado 2020
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437“…In the present study, the roles of the histone lysine demethylases JMJD2a and LSD1 in CK2 downregulation-mediated senescence were investigated. …”
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438“…BACKGROUND: Retinal ganglion cells (RGCs) are important retinal neurons that connect visual receptors to the brain, and lysine-specific demethylase 1 (LSD1) is implicated in the development of RGCs. …”
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439por Storm, Michael P., Kumpfmueller, Benjamin, Bone, Heather K., Buchholz, Michael, Sanchez Ripoll, Yolanda, Chaudhuri, Julian B., Niwa, Hitoshi, Tosh, David, Welham, Melanie J.“…Based on our data we propose that Zscan4 may regulate gene transcription in mouse ES cells through interaction with LSD1 and CtBP2.…”
Publicado 2014
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440por Xu, Tao, Park, Sung‐Soo, Giaimo, Benedetto Daniele, Hall, Daniel, Ferrante, Francesca, Ho, Diana M, Hori, Kazuya, Anhezini, Lucas, Ertl, Iris, Bartkuhn, Marek, Zhang, Honglai, Milon, Eléna, Ha, Kimberly, Conlon, Kevin P, Kuick, Rork, Govindarajoo, Brandon, Zhang, Yang, Sun, Yuqing, Dou, Yali, Basrur, Venkatesha, Elenitoba‐Johnson, Kojo SJ, Nesvizhskii, Alexey I, Ceron, Julian, Lee, Cheng‐Yu, Borggrefe, Tilman, Kovall, Rhett A, Rual, Jean‐François“…In the absence of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression. …”
Publicado 2017
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