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Abuso de drogas
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441por Hou, Guiqin, Zhao, Qi, Zhang, Mengying, Wang, Peng, Ye, Hua, Wang, Yang, Ren, Yandan, Zhang, Jianying, Lu, Zhaoming“…However, the regulatory relationship between LSD1 and Notch as well as PI3K/Akt/mTOR pathways is still unclear. …”
Publicado 2019
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442por Larsen, Jens Knud“…According to the LSD Damages Law from 1986, they all received financial compensation for LSD-inflicted harm. …”
Publicado 2021
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443por Fan, Cong, Ma, Xiaohan, Wang, Yuejun, Lv, Longwei, Zhu, Yuan, Liu, Hao, Liu, Yunsong“…Interrelationships between signaling pathways of NOTCH1-hairy and enhancer of split 1 (HES1), LSD1 and BMP2-SMADs were thoroughly investigated with separate knockdown of NOTCH1, LSD1, BMP2, and HES1. …”
Publicado 2021
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444por Liu, Meng, Du, Mengbao, Yu, Jian, Qian, Zijun, Gao, Yang, Pan, Wenjue, Zhao, Xiujie, Wang, Mowang, Li, Huimin, Zheng, Jiaqi, Huang, Qianshuo, Wang, Li-Mengmeng, Xiao, Haowen“…Finally, we identified that histone demethylase lysine-specific demethylase 1 (LSD1) inhibition can restore the expression of ULBPs via induction of CEBPA expression in AML cells, which may represent a novel therapeutic strategy for CEBPA-mutated AML. …”
Publicado 2022
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446“…Applying the abovementioned molecular modeling procedure yielded four compounds of LSD1/CoREST inhibiters with IC(50) < 2µM. The four lead compounds were tested against SH-SY5Y neuroblastoma cell line that known to express high level of LSD1 and illustrated a potent activity with an IC(50) ranging from 0.195 to 1.52µM. …”
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447por Alejo, Salvador, Palacios, Bridgitte, Venkata, Prabhakar Pitta, He, Yi, Li, Wenjing, Johnson, Jessica, Jayamohan, Sridharan, Vadlamudi, Ratna, Sareddy, GangadharaEnlace del recurso
Publicado 2023
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448por Derr, Remco S, van Hoesel, Anneke Q, Benard, Anne, Goossens-Beumer, Inès J, Sajet, Anita, Dekker-Ensink, N Geeske, de Kruijf, Esther M, Bastiaannet, Esther, Smit, Vincent THBM, van de Velde, Cornelis JH, Kuppen, Peter JK“…We investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in relation with patient survival and tumor relapse in a retrospective cohort of 460 breast cancer patients. …”
Publicado 2014
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449por Liu, Yan-wen, Xia, Rui, Lu, Kai, Xie, Min, Yang, Fen, Sun, Ming, De, Wei, Wang, Cailian, Ji, Guozhong“…Additionally, RIP assay and RNA-pulldown assay evidenced that FEZF1-AS1 could epigenetically repress the expression of P21 via binding with LSD1, the first discovered demethylase. ChIP assays demonstrated that LSD1 could directly bind to the promoter of P21, inducing H3K4me2 demethylation. …”
Publicado 2017
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450“…Therefore, LSD1 inactivators are expected to be used as therapeutic agents. …”
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451por Hoshino, Isamu, Takahashi, Masahiko, Akutsu, Yasunori, Murakami, Kentaro, Matsumoto, Yasunori, Suito, Hiroshi, Sekino, Nobufumi, Komatsu, Aki, Iida, Keiko, Suzuki, Takayoshi, Inoue, Itsuro, Ishige, Fumitaka, Iwatate, Yosuke, Matsubara, Hisahiro“…The effect of the lysine-specific histone demethylase 1 (LSD1) inhibitor, a demethylating enzyme of histones, is thought to be caused by controlling the expression of genes. …”
Publicado 2019
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452por Huang, Zebin, Li, Shangze, Song, Wei, Li, Xin, Li, Qinshan, Zhang, Zeyan, Han, Yongqing, Zhang, Xiaodong, Miao, Shiying, Du, Runlei, Wang, Linfang“…We collected paired samples of tumor and adjacent normal colorectal tissues from 22 patients with colorectal carcinoma to compare the differences in the expression of lysine specific demethylase 1 (LSD1) in these two tissues. The results showed that in 19 paired samples (86.4%), LSD1 is more highly expressed in tumor tissue than in normal tissue. …”
Publicado 2013
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453por Bennani-Baiti, Idriss M“…The relevance of PELP1-LSD1 signaling to other nuclear hormone receptor-dependent cancers and structural considerations for the selective drug targeting of LSD1 are further discussed in this editorial.…”
Publicado 2012
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454por Huang, Zebin, Li, Shangze, Song, Wei, Li, Xin, Li, Qinshan, Zhang, Zeyan, Han, Yongqing, Zhang, Xiaodong, Miao, Shiying, Du, Runlei, Wang, LinfangEnlace del recurso
Publicado 2013
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455por Zang, Chongshuang, Nie, Feng-qi, Wang, Qian, Sun, Ming, Li, Wei, He, Jing, Zhang, Meiling, Lu, Kai-hua“…Mechanistic investigations showed that LINC01133 could interact with EZH2, LSD1 and recruit them to KLF2, P21 or E-cadherin promoter regions to repress their transcription. …”
Publicado 2016
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456por Dolder, Patrick C., Grünblatt, Edna, Müller, Felix, Borgwardt, Stefan J., Liechti, Matthias E.“…Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT(2A) receptor downregulation. …”
Publicado 2017
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457por Liu, Fengting, Ma, Xiaofang, Bian, Xiyun, Zhang, Chunyan, Liu, Xiaozhi, Liu, Qiang“…Interaction among LINC00586, LSD1, and ASXL1 was determined by RNA immunoprecipitation and chromatin immunoprecipitation. …”
Publicado 2022
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458por Jin, Lihua, Hanigan, Christin L., Wu, Yu, Wang, Wei, Park, Ben Ho, Woster, Patrick M., Casero, Robert A.“…To examine the role of LSD1 we generated LSD1 heterozygous (LSD1(+/−)) and homozygous (LSD1(−/−)) knockouts in the human colorectal cancer cell line HCT116. …”
Publicado 2012
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460por Xu, Yi, Yao, Yue, Jiang, Xingming, Zhong, Xiangyu, Wang, Zhidong, Li, Chunlong, Kang, Pengcheng, Leng, Kaiming, Ji, Daolin, Li, Zhenglong, Huang, Lining, Qin, Wei, Cui, Yunfu“…Mechanistically, enhancer of zeste homolog 2 (EZH2) along with the lysine specific demethylase 1 (LSD1) or DNA methyltransferase 1 (DNMT1) were recruited by SPRY4-IT1, which functioned as a scaffold. …”
Publicado 2018
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