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Abuso de drogas
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LSD (Droga)
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41“…Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug affecting the mood and perception of an individual. …”
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42“…In this review, we summarize current knowledge about LSD1 and the molecular mechanism by which LSD1 influences the stem cells state, including the regulatory circuitry underlying self-renewal and pluripotency.…”
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43“…LSD administrations were matched to dose groups according to measured LSD peak plasma concentrations to adjust for uncertainties in the correct LSD dose in some studies. …”
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44por Li, Yu, Zhao, Yuanyuan, Li, Xiaona, Zhai, Liuqun, Zheng, Hua, Yan, Ying, Fu, Qiang, Ma, Jinlian, Fu, Haier, Zhang, Zhenqiang, Li, Zhonghua“…Pharmacological inhibition of LSD1 has shown promising therapeutic benefits for AD treatment. …”
Publicado 2022
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45“…PURPOSE: Many analogs of lysergic acid diethylamide (LSD) have recently appeared as designer drugs around the world. …”
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46“…BACKGROUND: Genetic studies of the Arabidopsis mutant lsd1 highlight the important role of LSD1 in the negative regulation of plant programmed cell death (PCD). …”
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47“…This review focuses on recent advances in LSD1 and tumor immunity and discusses a potential therapeutic strategy for combining LSD1 inhibition with immunotherapy.…”
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48“…Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. …”
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49por Kanen, Jonathan W., Luo, Qiang, Rostami Kandroodi, Mojtaba, Cardinal, Rudolf N., Robbins, Trevor W., Nutt, David J., Carhart-Harris, Robin L., den Ouden, Hanneke E. M.“…BACKGROUND: The non-selective serotonin 2A (5-HT(2A)) receptor agonist lysergic acid diethylamide (LSD) holds promise as a treatment for some psychiatric disorders. …”
Publicado 2023
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51por Duteil, Delphine, Metzger, Eric, Willmann, Dominica, Karagianni, Panagiota, Friedrichs, Nicolaus, Greschik, Holger, Günther, Thomas, Buettner, Reinhard, Talianidis, Iannis, Metzger, Daniel, Schüle, Roland“…Here we show that these stimuli increase the levels of lysine-specific demethylase 1 (LSD1) in WAT of mice and that elevated LSD1 levels induce mitochondrial activity. …”
Publicado 2014
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52por Feng, Zizhen, Yao, Yuan, Zhou, Chao, Chen, Fengju, Wu, Fangrui, Wei, Liping, Liu, Wei, Dong, Shuo, Redell, Michele, Mo, Qianxing, Song, Yongcheng“…METHODS: LSD1 inhibitors were examined for their biochemical and biological activities against LSD1 and MLL-rearranged leukemia as well as other cancer cells. …”
Publicado 2016
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53por Müller, Felix, Dolder, Patrick C., Schmidt, André, Liechti, Matthias E., Borgwardt, Stefan“…LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. …”
Publicado 2018
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54por Patel, Priyal O., Pishas, Kathleen I., Taslim, Cenny, Selich-Anderson, Julia, Theisen, Emily R., Lessnick, Stephen L.“…As such, the purpose of this study was to determine the role of LSD2 in the epigenetic regulation of Ewing sarcoma, characterize genes regulated by LSD2, and examine the impact of SP-2509 drug treatment on LSD2 gene regulation. …”
Publicado 2019
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55por Storck, William K, Bicocca, Vincent T, Rountree, Michael R, Honda, Shinji, Ormsby, Tereza, Selker, Eric U“…Though LSD1 is implicated in heterochromatin regulation, its function is inconsistent across different systems; orthologs of LSD1 have been shown to either promote or antagonize heterochromatin expansion by removing H3K4me or H3K9me respectively. …”
Publicado 2020
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56“…Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. …”
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57por Aakerøy, Rachel, Brede, Wenche Rødseth, Stølen, Stian Bergseng, Krabseth, Hege-Merete, Michelsen, Lisbeth Solem, Andreassen, Trine Naalsund, Ader, Tiina, Frost, Joachim, Slettom, Grete, Steihaug, Ole Martin, Slørdal, Lars“…In addition, no individual traits which would make the patient particularly susceptible to adverse LSD effects have subsequently been identified. This suggests that LSD may confer toxic effects in previously healthy individuals.…”
Publicado 2020
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58por Wang, Yue, Huang, Yunchao, Cheng, Edith, Liu, Xinhua, Zhang, Yu, Yang, Jianguo, Young, Jordan T. F., Brown, Grant W., Yang, Xiaohan, Shang, Yongfeng“…As selective inhibitors of LSD1 are being exploited as potential cancer therapeutics, our study supports the importance of leveraging an appropriate level of LSD1 to curb the side effects of anti-LSD1 therapy.…”
Publicado 2022
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59por Lawn, Timothy, Dipasquale, Ottavia, Vamvakas, Alexandros, Tsougos, Ioannis, Mehta, Mitul A., Howard, Matthew A.“…RATIONALE: LSD is the prototypical psychedelic. Despite a clear central role of the 5HT(2a) receptor in its mechanism of action, the contributions of additional receptors for which it shows affinity and agonist activity remain unclear. …”
Publicado 2022
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60“…Multiple components of the epigenetically repressive lysine-specific demethylase 1 (LSD1)/nucleosome remodeling and histone deacetylase (NuRD) complex, most notably LSD1 and histone deacetylase 2 (HDAC2), were found to be associated with Prox1 and GST pulldown assay demonstrated that Prox1 directly interacts with LSD1. …”
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