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Mostrando 721 - 740 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.31s Limitar resultados
  1. 721
    “…Here, we confirmed that Wnt signaling activated via BMP4 activates transcription of Lin28A by inducing β-catenin to compete with LSD1 for binding to TCF7L2, causing LSD1 to dissociate from the Lin28A promoter and enhancing H3K4me2 methylation in this region. …”
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    BMP4 activates the Wnt–Lin28A–Blimp1–Wnt pathway to promote primordial germ cell formation via altering H3K4me2
  2. 722
    “…The transcriptional silencing of pluripotency genes (PpGs) during ESC differentiation is accompanied by PpG enhancer (PpGe) silencing mediated by the demethylation of H3K4me1 by LSD1. Our MethylRAD data show that in the presence of LSD1 inhibitor, a significant fraction of LSD1-bound PpGe fails to gain DNA methylation. …”
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    Simplified MethylRAD Sequencing to Detect Changes in DNA Methylation at Enhancer Elements in Differentiating Embryonic Stem Cells
  3. 723
    “…Lumpy skin disease (LSD) is a severe and highly infectious pox disease of cattle caused by the lumpy skin disease virus (LSDV). …”
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    Sensitive and Specific Detection of Lumpy Skin Disease Virus in Cattle by CRISPR-Cas12a Fluorescent Assay Coupled with Recombinase Polymerase Amplification
  4. 724
    por Mauri, Federico, Blanpain, Cédric
    Publicado 2020
    “…In this issue of EMBO Molecular Medicine, Leiendecker et al identify a selective vulnerability of MCC for inhibitors of the lysine‐specific histone demethylase 1A (LSD1). LSD1 inhibitors promote differentiation of tumor cells toward normal Merkel cell fate, impairing tumor cell growth in vivo, and opening new avenues for the treatment of patients with MCC.…”
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    Targeting the epigenetic addiction of Merkel cell carcinoma
  5. 725
    “…Knockdown of OVOL2 in LSD1 knockout HCT116 cells restored the cancer cell phenotype. …”
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    Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications
  6. 726
    “…BACKGROUND AND AIM: Lumpy skin disease (LSD) and sheep pox are economically important Capripoxvirus-induced diseases of cattle and sheep, respectively. …”
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    Capripoxviruses: Exploring the genetic relatedness between field and vaccine strains from Egypt
  7. 727
    “…METHODS: We used a custom next‐generation sequencing panel, including 50 LSD genes, to screen 305 patients and 207 controls (discovery cohort). …”
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    Role of Lysosomal Gene Variants in Modulating GBA ‐Associated Parkinson's Disease Risk
  8. 728
    “…BACKGROUND: Portal vein system thrombosis (PVST) is a common postoperative complication brought by laparoscopic splenectomy and pericardial disconnection (LSD) among patients who suffered from portal hypertension and hypersplenism. …”
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    Early prevention and risk factors analysis of portal vein system thrombosis after laparoscopic splenectomy and pericardial devascularization
  9. 729
    “…The first three groups included different stocking densities of broiler birds (low stocking density, LSD: 23 kg/m(2); medium stocking density, MSD: 34 kg birds/m(2); and high stocking density HSD: 39 kg birds/m(2)). …”
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    Effect of stocking density and vitamin E or zinc supplementation on growth, physiology, gene expression, and economic efficiency of growing broiler chicks
  10. 730
    “…Both short sleep duration (SSD) and long sleep duration (LSD) are associated with an increased risk of morbidity and mortality. …”
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    Sleep duration, hypnotic drug use, and risk factors: cross- sectional study
  11. 731
    “…One hundred one subjects with (n = 31, 57.7 ± 9.8 yr) or without hypertension (n = 70, 40.8 ± 16.5 yr) were given a low-sodium dietary approache to stop hypertension (DASH) diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. …”
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    Characteristics of Sodium Sensitivity in Korean Populations
  12. 732
    “…OsMC1 interacted with OsLSD1 and OsLSD3 while OsMC3 only interacted with OsLSD1 and that the zinc finger domain in OsMC1 is responsible for the interaction activity. …”
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    Stress-Responsive Expression, Subcellular Localization and Protein–Protein Interactions of the Rice Metacaspase Family
  13. 733
    “…The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic spread of TNBC cell lines. …”
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    Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity()()()
  14. 734
    “…Included studies involved the administration of a single or a few doses of LSD or psilocybin, and most trials were randomized and controlled with placebo. …”
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    Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature
  15. 735
    “…Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by autosomal recessive mutations of the glucocerebrosidase gene, GBA1. …”
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    Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease
  16. 736
    “…In November 2020, Myanmar reported its first LSD outbreak. This study reports on the first incursion of LSD in Myanmar and the molecular analysis of the LSDV detected. …”
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    First Report of Lumpy Skin Disease in Myanmar and Molecular Analysis of the Field Virus Isolates
  17. 737
    “…BACKGROUND: Lumpy skin disease (LSD), a disease transmitted by direct and indirect contact with infected cattle, is caused by the Lumpy skin disease virus (LSDV). …”
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    Molecular identification and characterization of Lumpy skin disease virus emergence from cattle in the northeastern part of Thailand
  18. 738
    “…LSD1 silencing enhanced CFZ sensitivity in both PI-resistant and -sensitive MM cells, resulting in increased tumor cell death. …”
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    Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma
  19. 739
    “…OBJECTIVES: The present meta-analysis aims to advance our understanding of the most widely used serotonergic psychedelics – LSD, psilocybin, and MDMA – by examining their effects on the functional activation throughout the whole brain among both clinical and healthy participants. …”
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    The Effects of Serotonergic Psychedelics on Neural Activity: A Meta-Analysis of Task-Based Functional Neuroimaging Studies
  20. 740
    “…Inhibition of MED1, HDAC4, or LSD1 by siRNA also attenuates ligand-induced chromatin looping. …”
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    Cyclical Chromatin Looping and Transcription Factor Association on the Regulatory Regions of the p21 (CDKN1A) Gene in Response to 1α,25-Dihydroxyvitamin D(3)
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