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721“…Here, we confirmed that Wnt signaling activated via BMP4 activates transcription of Lin28A by inducing β-catenin to compete with LSD1 for binding to TCF7L2, causing LSD1 to dissociate from the Lin28A promoter and enhancing H3K4me2 methylation in this region. …”
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722“…The transcriptional silencing of pluripotency genes (PpGs) during ESC differentiation is accompanied by PpG enhancer (PpGe) silencing mediated by the demethylation of H3K4me1 by LSD1. Our MethylRAD data show that in the presence of LSD1 inhibitor, a significant fraction of LSD1-bound PpGe fails to gain DNA methylation. …”
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723por Jiang, Chuanwen, Tao, Dagang, Geng, Yuanchen, Yang, Hao, Xu, Bingrong, Chen, Yingyu, Hu, Changmin, Chen, Huanchun, Xie, Shengsong, Guo, Aizhen“…Lumpy skin disease (LSD) is a severe and highly infectious pox disease of cattle caused by the lumpy skin disease virus (LSDV). …”
Publicado 2022
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724“…In this issue of EMBO Molecular Medicine, Leiendecker et al identify a selective vulnerability of MCC for inhibitors of the lysine‐specific histone demethylase 1A (LSD1). LSD1 inhibitors promote differentiation of tumor cells toward normal Merkel cell fate, impairing tumor cell growth in vivo, and opening new avenues for the treatment of patients with MCC.…”
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725“…Knockdown of OVOL2 in LSD1 knockout HCT116 cells restored the cancer cell phenotype. …”
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726“…BACKGROUND AND AIM: Lumpy skin disease (LSD) and sheep pox are economically important Capripoxvirus-induced diseases of cattle and sheep, respectively. …”
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727por Straniero, Letizia, Rimoldi, Valeria, Monfrini, Edoardo, Bonvegna, Salvatore, Melistaccio, Giada, Lake, Julie, Soldà, Giulia, Aureli, Massimo, Shankaracharya, Keagle, Pamela, Foroud, Tatiana, Landers, John E., Blauwendraat, Cornelis, Zecchinelli, Anna, Cilia, Roberto, Di Fonzo, Alessio, Pezzoli, Gianni, Duga, Stefano, Asselta, Rosanna“…METHODS: We used a custom next‐generation sequencing panel, including 50 LSD genes, to screen 305 patients and 207 controls (discovery cohort). …”
Publicado 2022
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728“…BACKGROUND: Portal vein system thrombosis (PVST) is a common postoperative complication brought by laparoscopic splenectomy and pericardial disconnection (LSD) among patients who suffered from portal hypertension and hypersplenism. …”
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729por Shehata, Seham F., Baloza, Samar H., Elsokary, Mohamed M. M., Hashem, Nesrein M., Khawanda, Maha M.“…The first three groups included different stocking densities of broiler birds (low stocking density, LSD: 23 kg/m(2); medium stocking density, MSD: 34 kg birds/m(2); and high stocking density HSD: 39 kg birds/m(2)). …”
Publicado 2022
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730por Jalali, Nazanin, Khalili, Parvin, Jamali, Zahra, Jalali, Zahra, Moghadam-Ahmadi, Amir, Vakilian, Alireza, Ayoobi, Fatemeh“…Both short sleep duration (SSD) and long sleep duration (LSD) are associated with an increased risk of morbidity and mortality. …”
Publicado 2023
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731por Shin, Sung Joon, Lim, Chi Yeon, Rhee, Moo-Yong, Oh, Sang Woo, Na, Sang Hoon, Park, Yongsoon, Kim, Cho-il, Kim, Seo-Young, Kim, Jong-Wook, Park, Hye-Kyung“…One hundred one subjects with (n = 31, 57.7 ± 9.8 yr) or without hypertension (n = 70, 40.8 ± 16.5 yr) were given a low-sodium dietary approache to stop hypertension (DASH) diet (LSD) for 7 days and a high-sodium DASH diet (HSD) for the following 7 days. …”
Publicado 2011
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732por Huang, Lei, Zhang, Huijuan, Hong, Yongbo, Liu, Shixia, Li, Dayong, Song, Fengming“…OsMC1 interacted with OsLSD1 and OsLSD3 while OsMC3 only interacted with OsLSD1 and that the zinc finger domain in OsMC1 is responsible for the interaction activity. …”
Publicado 2015
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733por Ferrari-Amorotti, Giovanna, Chiodoni, Claudia, Shen, Fei, Cattelani, Sara, Soliera, Angela Rachele, Manzotti, Gloria, Grisendi, Giulia, Dominici, Massimo, Rivasi, Francesco, Colombo, Mario Paolo, Fatatis, Alessandro, Calabretta, Bruno“…The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic spread of TNBC cell lines. …”
Publicado 2014
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734por Rocha, Juliana M., Osório, Flávia L., Crippa, José Alexandre S., Bouso, José Carlos, Rossi, Giordano N., Hallak, Jaime E. C., dos Santos, Rafael G.“…Included studies involved the administration of a single or a few doses of LSD or psilocybin, and most trials were randomized and controlled with placebo. …”
Publicado 2019
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735por Wei, Jianshe, Takamatsu, Yoshiki, Wada, Ryoko, Fujita, Masayo, Ho, Gilbert, Masliah, Eliezer, Hashimoto, Makoto“…Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by autosomal recessive mutations of the glucocerebrosidase gene, GBA1. …”
Publicado 2021
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736por Maw, Min Thein, Khin, Myint Myint, Hadrill, David, Meki, Irene Kasindi, Settypalli, Tirumala Bharani Kumar, Kyin, Maung Maung, Myint, Win Win, Thein, Wai Zin, Aye, Ohnmar, Palamara, Elisa, Win, Ye Tun, Cattoli, Giovanni, Lamien, Charles Euloge“…In November 2020, Myanmar reported its first LSD outbreak. This study reports on the first incursion of LSD in Myanmar and the molecular analysis of the LSDV detected. …”
Publicado 2022
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737“…BACKGROUND: Lumpy skin disease (LSD), a disease transmitted by direct and indirect contact with infected cattle, is caused by the Lumpy skin disease virus (LSDV). …”
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738por Bandini, Cecilia, Mereu, Elisabetta, Paradzik, Tina, Labrador, Maria, Maccagno, Monica, Cumerlato, Michela, Oreglia, Federico, Prever, Lorenzo, Manicardi, Veronica, Taiana, Elisa, Ronchetti, Domenica, D’Agostino, Mattia, Gay, Francesca, Larocca, Alessandra, Besse, Lenka, Merlo, Giorgio Roberto, Hirsch, Emilio, Ciarrocchi, Alessia, Inghirami, Giorgio, Neri, Antonino, Piva, Roberto“…LSD1 silencing enhanced CFZ sensitivity in both PI-resistant and -sensitive MM cells, resulting in increased tumor cell death. …”
Publicado 2023
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739por Shepherd, J. H., Baten, C., Klassen, A., Zamora, G., Saravia, S., Pritchard, E., Ali, Z., Kahlon, S. K., Whitelock, K., Reyes, F. A., Hedges, D. W., Hamilton, J. P., Sacchet, M. D., Miller, C. H.“…OBJECTIVES: The present meta-analysis aims to advance our understanding of the most widely used serotonergic psychedelics – LSD, psilocybin, and MDMA – by examining their effects on the functional activation throughout the whole brain among both clinical and healthy participants. …”
Publicado 2023
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740por Saramäki, Anna, Diermeier, Sarah, Kellner, Ruth, Laitinen, Heidi, Vaïsänen, Sami, Carlberg, Carsten“…Inhibition of MED1, HDAC4, or LSD1 by siRNA also attenuates ligand-induced chromatin looping. …”
Publicado 2009
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