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741“…The existing registries for orphan drug treatments for lysosomal storage disorders (LSD's) illustrate these limitations. LSD's are inherited disorders of lysosomal metabolism with a wide variety in clinical symptoms, ranging from severe life-threatening neurological disease to mild or even asymptomatic cases. …”
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742por Lopez, Manuel E., Klein, Andrés D., Hong, Jennifer, Dimbil, Ubah J., Scott, Matthew P.“…Deletion of Ccl3 had been reported to delay neuronal loss in Sandhoff LSD mice by inhibiting macrophage infiltration. …”
Publicado 2012
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743por Zhang, Kailiang, Sun, Xiaotian, Zhou, Xuan, Han, Lei, Chen, Luyue, Shi, Zhendong, Zhang, Anling, Ye, Minhua, Wang, Qixue, Liu, Chaoyong, Wei, Jianwei, Ren, Yu, Yang, Jingxuan, Zhang, Jianning, Pu, Peiyu, Li, Min, Kang, Chunsheng“…However, the inhibition of LSD1 did not affect cell cycle progression in glioma cells. …”
Publicado 2014
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744por Hu, Xiangjing, Shen, Bin, Liao, Shangying, Ning, Yan, Ma, Longfei, Chen, Jian, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Zheng, Chunwei, Feng, Yanmin, Huang, Xingxu, Han, Chunsheng“…ZMYM3 co-immunoprecipitated with LSD1 in spermatogonial stem cells, but its KO did not change the levels of LSD1 or H3K4me1/2 or H3K9me2. …”
Publicado 2017
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745por Engel, Martin, Gee, Yi Sing, Cross, Dale, Maccarone, Alan, Heng, Benjamin, Hulme, Amy, Smith, Grady, Guillemin, Gilles J., Stringer, Brett W., Hyland, Christopher J. T., Ooi, Lezanne“…Altered histone 3 lysine 4 methylation and increased lysine‐specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mechanisms are involved in GBM. …”
Publicado 2019
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746por Encarnação, Marisa, Coutinho, Maria Francisca, Silva, Lisbeth, Ribeiro, Diogo, Ouesleti, Souad, Campos, Teresa, Santos, Helena, Martins, Esmeralda, Cardoso, Maria Teresa, Vilarinho, Laura, Alves, Sandra“…One of the novel pathogenic variants was identified in the GM2A gene, which is associated with an ultra-rare (or misdiagnosed) LSD, the AB variant of GM2 Gangliosidosis. Overall, this case series highlights not only the major advantages of NGS-based diagnostic approaches but also, to some extent, its limitations ultimately promoting a reflection on the role of targeted panels as a primary tool for the prompt characterization of LSD patients.…”
Publicado 2020
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747“…Both the groups, performed poorly on LSD type of sentence when compared to other sentence types. …”
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748por Zhang, Freddy, Rein, Benjamin, Zhong, Ping, Shwani, Treefa, Conrow-Graham, Megan, Wang, Zi-Jun, Yan, Zhen“…We found that combined administration of the class I histone deacetylase inhibitor Romidepsin and the histone demethylase LSD1 inhibitor GSK-LSD1 persistently ameliorated the autism-like social preference deficits, while each individual drug alone was largely ineffective. …”
Publicado 2021
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749“…Sleep duration was divided into three categories: short sleep duration (SSD) (≤5 h), normal sleep duration (NSD) (>5 and <9 h), and long sleep duration (LSD) (≥9 h). Sampling weights were applied to obtain estimates for the general Korean population. …”
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750por Che, Di, Wang, Mingshuo, Sun, Juan, Li, Bo, Xu, Tao, Lu, Yuxiong, Pan, Haiyan, Lu, Zhaoliang, Gu, Xiaoqiong“…Together, KRT6A and LSD1 may serve as potential prognostic indictors and therapeutic targets for NSCLC.…”
Publicado 2021
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751“…CONCLUSIONS: Eupalinilide B might be a novel LSD1 inhibitor for treating laryngeal cancer.…”
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752por Paslaru, Anca I., Verhulst, Niels O., Maurer, Lena M., Brendle, Alexsandra, Pauli, Nicole, Vögtlin, Andrea, Renzullo, Sandra, Ruedin, Yelena, Hoffmann, Bernd, Torgerson, Paul R., Mathis, Alexander, Veronesi, Eva“…Lumpy skin disease (LSD) is a viral disorder of cattle caused by the lumpy skin disease virus (LSDV) which can induce severe infections leading to high economic losses. …”
Publicado 2020
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753“…The diagnosis of all LSD is based on enzymatic activity, tissue histology, and genetic testing. …”
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754por Serpa, Mauricio, Loch, Alexandre Andrade, Chianca, Camille, Freitas, Elder, Andrade, Julio Cesar, Alves, Tania Maria, Hortêncio, Lucas, van de Bilt, Martinus Theodorus, Gattaz, Wagner, Rossler, Wulf“…UHR subjects history of lifetime drug use was: 19 (38%) cannabis; 5 (10%) snorted cocaine; 1 (2%) crack; 1 (2%) amphetamine; 2 (6.9%) LSD. EC history of lifetime drug use was: 20 (24.4%) cannabis; 6 (7.3%) snorted cocaine; 0 crack; 2 (2.4%) amphetamine; 1 (1.2%) LSD. …”
Publicado 2018
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755por Meagher, David J, O’Connell, Henry, Leonard, Maeve, Williams, Olugbenga, Awan, Fahad, Exton, Chris, Tenorio, Michael, O’Connor, Margaret, Dunne, Colum P, Cullen, Walter, McFarland, John, Adamis, Dimitrios“…The Lighthouse test and the LSD-4 are novel tests with high accuracy for detecting delirium.…”
Publicado 2020
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756por Qiu, Juan, Li, Rendong, Zhu, Hong, Xia, Jing, Xiao, Ying, Huang, Duan, Wang, Yong“…Continuous mollusciciding could result in significant LSD reduction, but may not lead to significant SIA reduction. …”
Publicado 2020
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757por Petersen, Kristina S, Davis, Kristin M, Rogers, Connie J, Proctor, David N, West, Sheila G, Kris-Etherton, Penny M“…The HSD lowered mean 24-h diastolic blood pressure compared with the LSD (−1.5 mm Hg; 95% CI: −2.5, −0.4 mm Hg; P = 0.003). …”
Publicado 2021
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758por Chang, Yao-Lung, Hsu, Chin-Chieh, Chao, An-Shine, Chang, Shuenn-Dyh, Cheng, Po-Jen, Li, Wen-Fang“…Moreover, the TWPs decreased after FLP, that is, from M1 to M2 (66.2% vs. 46.8%, respectively, p = 0.002, LSD test) and increased after delivery, that is, from M2 to M3 (46.8% vs. 63.2%, respectively, p = 0.024, LSD test). …”
Publicado 2022
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759por Sow, Samba O., Muhsen, Khitam, Nasrin, Dilruba, Blackwelder, William C., Wu, Yukun, Farag, Tamer H., Panchalingam, Sandra, Sur, Dipika, Zaidi, Anita K. M., Faruque, Abu S. G., Saha, Debasish, Adegbola, Richard, Alonso, Pedro L., Breiman, Robert F., Bassat, Quique, Tamboura, Boubou, Sanogo, Doh, Onwuchekwa, Uma, Manna, Byomkesh, Ramamurthy, Thandavarayan, Kanungo, Suman, Ahmed, Shahnawaz, Qureshi, Shahida, Quadri, Farheen, Hossain, Anowar, Das, Sumon K., Antonio, Martin, Hossain, M. Jahangir, Mandomando, Inacio, Nhampossa, Tacilta, Acácio, Sozinho, Omore, Richard, Oundo, Joseph O., Ochieng, John B., Mintz, Eric D., O’Reilly, Ciara E., Berkeley, Lynette Y., Livio, Sofie, Tennant, Sharon M., Sommerfelt, Halvor, Nataro, James P., Ziv-Baran, Tomer, Robins-Browne, Roy M., Mishcherkin, Vladimir, Zhang, Jixian, Liu, Jie, Houpt, Eric R., Kotloff, Karen L., Levine, Myron M.“…METHODS: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. …”
Publicado 2016
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760por Onyenwoke, Rob U., Sexton, Jonathan Z., Yan, Feng, Díaz, María Cristina Huertas, Forsberg, Lawrence J., Major, Michael B., Brenman, Jay E.“…During autophagy, aberrant regulation of the lysosomal Ca(2+) efflux channel TRPML1 [transient receptor potential mucolipin 1 (MCOLN1)], also known as MCOLN1, is solely responsible for the human LSD mucolipidosis type IV (MLIV); however, the exact mechanisms involved in the development of the pathology of this LSD are unknown. …”
Publicado 2015
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