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Mostrando 741 - 760 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.22s Limitar resultados
  1. 741
    “…The existing registries for orphan drug treatments for lysosomal storage disorders (LSD's) illustrate these limitations. LSD's are inherited disorders of lysosomal metabolism with a wide variety in clinical symptoms, ranging from severe life-threatening neurological disease to mild or even asymptomatic cases. …”
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    Limitations of drug registries to evaluate orphan medicinal products for the treatment of lysosomal storage disorders
  2. 742
    “…Deletion of Ccl3 had been reported to delay neuronal loss in Sandhoff LSD mice by inhibiting macrophage infiltration. …”
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    Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C
  3. 743
    “…However, the inhibition of LSD1 did not affect cell cycle progression in glioma cells. …”
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    Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner
  4. 744
    “…ZMYM3 co-immunoprecipitated with LSD1 in spermatogonial stem cells, but its KO did not change the levels of LSD1 or H3K4me1/2 or H3K9me2. …”
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    Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint
  5. 745
    “…Altered histone 3 lysine 4 methylation and increased lysine‐specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mechanisms are involved in GBM. …”
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    Novel dual‐action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine‐specific histone demethylase 1A inhibitor
  6. 746
    “…One of the novel pathogenic variants was identified in the GM2A gene, which is associated with an ultra-rare (or misdiagnosed) LSD, the AB variant of GM2 Gangliosidosis. Overall, this case series highlights not only the major advantages of NGS-based diagnostic approaches but also, to some extent, its limitations ultimately promoting a reflection on the role of targeted panels as a primary tool for the prompt characterization of LSD patients.…”
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    Assessing Lysosomal Disorders in the NGS Era: Identification of Novel Rare Variants
  7. 747
    por Darshan, H S, Goswami, S P
    Publicado 2020
    “…Both the groups, performed poorly on LSD type of sentence when compared to other sentence types. …”
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    Effect of Distance between Marker Agreement Dependencies on Sentence Comprehension in Persons with Aphasia
  8. 748
    “…We found that combined administration of the class I histone deacetylase inhibitor Romidepsin and the histone demethylase LSD1 inhibitor GSK-LSD1 persistently ameliorated the autism-like social preference deficits, while each individual drug alone was largely ineffective. …”
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    Synergistic inhibition of histone modifiers produces therapeutic effects in adult Shank3-deficient mice
  9. 749
    por Ko, Yujin, Moon, Jieun, Han, Sangsoo
    Publicado 2021
    “…Sleep duration was divided into three categories: short sleep duration (SSD) (≤5 h), normal sleep duration (NSD) (>5 and <9 h), and long sleep duration (LSD) (≥9 h). Sampling weights were applied to obtain estimates for the general Korean population. …”
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    Sleep Duration Is Closely Associated with Suicidal Ideation and Suicide Attempt in Korean Adults: A Nationwide Cross-Sectional Study
  10. 750
    “…Together, KRT6A and LSD1 may serve as potential prognostic indictors and therapeutic targets for NSCLC.…”
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    KRT6A Promotes Lung Cancer Cell Growth and Invasion Through MYC-Regulated Pentose Phosphate Pathway
  11. 751
    por Jiang, Linlin, Zhang, Lei, Zhang, Xinran
    Publicado 2022
    “…CONCLUSIONS: Eupalinilide B might be a novel LSD1 inhibitor for treating laryngeal cancer.…”
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    Eupalinilide B as a novel anti-cancer agent that inhibits proliferation and epithelial–mesenchymal transition in laryngeal cancer cells
  12. 752
    “…Lumpy skin disease (LSD) is a viral disorder of cattle caused by the lumpy skin disease virus (LSDV) which can induce severe infections leading to high economic losses. …”
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    Potential mechanical transmission of Lumpy skin disease virus (LSDV) by the stable fly (Stomoxys calcitrans) through regurgitation and defecation
  13. 753
    “…The diagnosis of all LSD is based on enzymatic activity, tissue histology, and genetic testing. …”
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    Natural history and management of liver dysfunction in lysosomal storage disorders
  14. 754
    “…UHR subjects history of lifetime drug use was: 19 (38%) cannabis; 5 (10%) snorted cocaine; 1 (2%) crack; 1 (2%) amphetamine; 2 (6.9%) LSD. EC history of lifetime drug use was: 20 (24.4%) cannabis; 6 (7.3%) snorted cocaine; 0 crack; 2 (2.4%) amphetamine; 1 (1.2%) LSD. …”
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    T203. ILLICIT DRUGS USE AND ULTRA-HIGH RISK (UHR) FOR PSYCHOSIS STATUS IN A LATIN-AMERICAN SAMPLE
  15. 755
    “…The Lighthouse test and the LSD-4 are novel tests with high accuracy for detecting delirium.…”
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    Comparison of novel tools with traditional cognitive tests in detecting delirium in elderly medical patients
  16. 756
    “…Continuous mollusciciding could result in significant LSD reduction, but may not lead to significant SIA reduction. …”
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    The effect of ecological environmental changes and mollusciciding on snail intermediate host of Schistosoma in Qianjiang city of China from 1985 to 2015
  17. 757
    “…The HSD lowered mean 24-h diastolic blood pressure compared with the LSD (−1.5 mm Hg; 95% CI: −2.5, −0.4 mm Hg; P = 0.003). …”
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    Herbs and spices at a relatively high culinary dosage improves 24-hour ambulatory blood pressure in adults at risk of cardiometabolic diseases: a randomized, crossover, controlled-feeding study
  18. 758
    “…Moreover, the TWPs decreased after FLP, that is, from M1 to M2 (66.2% vs. 46.8%, respectively, p = 0.002, LSD test) and increased after delivery, that is, from M2 to M3 (46.8% vs. 63.2%, respectively, p = 0.024, LSD test). …”
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    Effect of Fetoscopic Laser Photocoagulation on Fetal Growth and Placental Perfusion in Twin–Twin Transfusion Syndrome
  19. 759
    por Sow, Samba O., Muhsen, Khitam, Nasrin, Dilruba, Blackwelder, William C., Wu, Yukun, Farag, Tamer H., Panchalingam, Sandra, Sur, Dipika, Zaidi, Anita K. M., Faruque, Abu S. G., Saha, Debasish, Adegbola, Richard, Alonso, Pedro L., Breiman, Robert F., Bassat, Quique, Tamboura, Boubou, Sanogo, Doh, Onwuchekwa, Uma, Manna, Byomkesh, Ramamurthy, Thandavarayan, Kanungo, Suman, Ahmed, Shahnawaz, Qureshi, Shahida, Quadri, Farheen, Hossain, Anowar, Das, Sumon K., Antonio, Martin, Hossain, M. Jahangir, Mandomando, Inacio, Nhampossa, Tacilta, Acácio, Sozinho, Omore, Richard, Oundo, Joseph O., Ochieng, John B., Mintz, Eric D., O’Reilly, Ciara E., Berkeley, Lynette Y., Livio, Sofie, Tennant, Sharon M., Sommerfelt, Halvor, Nataro, James P., Ziv-Baran, Tomer, Robins-Browne, Roy M., Mishcherkin, Vladimir, Zhang, Jixian, Liu, Jie, Houpt, Eric R., Kotloff, Karen L., Levine, Myron M.
    Publicado 2016
    “…METHODS: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. …”
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    The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS)
  20. 760
    “…During autophagy, aberrant regulation of the lysosomal Ca(2+) efflux channel TRPML1 [transient receptor potential mucolipin 1 (MCOLN1)], also known as MCOLN1, is solely responsible for the human LSD mucolipidosis type IV (MLIV); however, the exact mechanisms involved in the development of the pathology of this LSD are unknown. …”
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    The mucolipidosis IV Ca(2+) channel TRPML1 (MCOLN1) is regulated by the TOR kinase
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