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Mostrando 61 - 80 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.13s Limitar resultados
  1. 61
    “…Lysine-specific demethylase 1 (LSD1) is a histone modifier for transcriptional repression involved in the regulation of hematopoiesis. …”
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    Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells
  2. 62
    por Pichon, G
    Publicado 1972
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    Off-Line Treatment of Measurements Performed on CERN's Spiral Readers (LSD)
  3. 63
    “…The effect of LSD1 inhibition involves transcription factors that directly interact with LSD1 such as GFI1 and GFI1B, but also transcription factors that bind to enhancers that are modulated by LSD1 such as PU.1 and C/EBPα as well as transcription factors that are regulated downstream of LSD1 such as IRF8. …”
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    LSD1 inhibition modulates transcription factor networks in myeloid malignancies
  4. 64
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    LSD 4.0: an improved database for comparative studies of leaf senescence
  5. 65
    “…Mechanistically, LSD1 occupies the promoters of FBP1 and G6Pase, and modulates their H3K4 dimethylation levels. …”
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    Suppression of Gluconeogenic Gene Expression by LSD1-Mediated Histone Demethylation
  6. 66
    “…This study describes the design and synthesis of analogues of a monoamine oxidase antidepressant, phenelzine, and their LSD1 inhibitory properties. A novel phenelzine analogue (bizine) containing a phenyl-butyrylamide appendage was shown to be a potent LSD1 inhibitor in vitro and was selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2. …”
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    A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
  7. 67
    “…Targeted inhibition of the context‐dependent activities of LSD1 may provide a highly selective means to eliminate cancer cells.…”
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    Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells
  8. 68
    “…LSD is well-known to induce perceptual alterations, but unknown is whether LSD alters emotional processing in ways that can support psychotherapy. …”
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    LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality
  9. 69
    “…Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. …”
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    Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue
  10. 70
    “…RATIONALE: Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. …”
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    Alterations of consciousness and mystical-type experiences after acute LSD in humans
  11. 71
    “…Lysine-specific demethylase 1 (LSD1) is a nuclear histone demethylase and a member of the amine oxidase (AO) family. …”
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    Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis
  12. 72
    “…Consistent with this, loss of LSD1 activity during differentiation enhanced the oxidative capacity of myotubes. …”
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    LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
  13. 73
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    LSD1 inhibitors disrupt the GFI1 transcription repressor complex
  14. 74
    “…We also show that Lsd1 is essential for Gfi1-mediated transformation: Gfi1 proteins that cannot recruit Lsd1 are unable to drive tumorigenesis, and genetic ablation of Lsd1 markedly impairs tumor growth in vivo. …”
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    Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
  15. 75
    “…To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after acute administration of lysergic acid diethylamide (LSD), and after pretreatment with Ketanserin (a selective serotonin 2A receptor antagonist) plus LSD in a double-blind, randomized, placebo-controlled, cross-over study in 25 healthy participants. …”
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    Effective connectivity changes in LSD-induced altered states of consciousness in humans
  16. 76
    “…Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. …”
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    Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
  17. 77
    “…Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, and d-amphetamine is a classic stimulant. …”
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    Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects
  18. 78
    “…In this study, we investigated the structures and expression of LSD1 splicing variants in zebrafish and found all 4 types of LSD1 isoforms: LSD1, LSD1+2al, LSD1+8al and LSD1+2al8al. …”
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    Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis
  19. 79
    “…Furthermore, LSD1 is overexpressed in various cancers. Therefore, LSD1 inhibitors would be not only potential therapeutic agents for cancers but also chemical tools to research biological significance of LSD1 in physiological and pathological events. …”
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    Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity
  20. 80
    “…Previously, our laboratory implicated the histone demethylase LSD1 in tau-induced neurodegeneration by showing that LSD1 localizes to pathological tau aggregates in Alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. …”
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    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
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