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61por Yamamoto, Ryusuke, Kawahara, Masahiro, Ito, Shinji, Satoh, Junko, Tatsumi, Goichi, Hishizawa, Masakatsu, Suzuki, Takayoshi, Andoh, Akira“…Lysine-specific demethylase 1 (LSD1) is a histone modifier for transcriptional repression involved in the regulation of hematopoiesis. …”
Publicado 2018
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63“…The effect of LSD1 inhibition involves transcription factors that directly interact with LSD1 such as GFI1 and GFI1B, but also transcription factors that bind to enhancers that are modulated by LSD1 such as PU.1 and C/EBPα as well as transcription factors that are regulated downstream of LSD1 such as IRF8. …”
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64por Cao, Jie, Zhang, Yang, Tan, Shuya, Yang, Qi, Wang, Hou-Ling, Xia, Xinli, Luo, Jingchu, Guo, Hongwei, Zhang, Zhang, Li, ZhonghaiEnlace del recurso
Publicado 2022
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65“…Mechanistically, LSD1 occupies the promoters of FBP1 and G6Pase, and modulates their H3K4 dimethylation levels. …”
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66por Prusevich, Polina, Kalin, Jay H., Ming, Shonoi A., Basso, Manuela, Givens, Jeffrey, Li, Xin, Hu, Jianfei, Taylor, Martin S., Cieniewicz, Anne M., Hsiao, Po-Yuan, Huang, Rong, Roberson, Heather, Adejola, Nkosi, Avery, Lindsay B., Casero, Robert A., Taverna, Sean D., Qian, Jiang, Tackett, Alan J., Ratan, Rajiv R., McDonald, Oliver G., Feinberg, Andrew P., Cole, Philip A.“…This study describes the design and synthesis of analogues of a monoamine oxidase antidepressant, phenelzine, and their LSD1 inhibitory properties. A novel phenelzine analogue (bizine) containing a phenyl-butyrylamide appendage was shown to be a potent LSD1 inhibitor in vitro and was selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2. …”
Publicado 2014
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67“…Targeted inhibition of the context‐dependent activities of LSD1 may provide a highly selective means to eliminate cancer cells.…”
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68por Dolder, Patrick C, Schmid, Yasmin, Müller, Felix, Borgwardt, Stefan, Liechti, Matthias E“…LSD is well-known to induce perceptual alterations, but unknown is whether LSD alters emotional processing in ways that can support psychotherapy. …”
Publicado 2016
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69por Duteil, Delphine, Tosic, Milica, Lausecker, Franziska, Nenseth, Hatice Z., Müller, Judith M., Urban, Sylvia, Willmann, Dominica, Petroll, Kerstin, Messaddeq, Nadia, Arrigoni, Laura, Manke, Thomas, Kornfeld, Jan-Wilhelm, Brüning, Jens C., Zagoriy, Vyacheslav, Meret, Michael, Dengjel, Jörn, Kanouni, Toufike, Schüle, Roland“…Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. …”
Publicado 2016
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70“…RATIONALE: Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. …”
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71por Alsaqer, Saqer F., Tashkandi, Mustafa M., Kartha, Vinay K., Yang, Ya-Ting, Alkheriji, Yazeed, Salama, Andrew, Varelas, Xaralabos, Kukuruzinska, Maria, Monti, Stefano, Bais, Manish V.“…Lysine-specific demethylase 1 (LSD1) is a nuclear histone demethylase and a member of the amine oxidase (AO) family. …”
Publicado 2017
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72por Anan, Kotaro, Hino, Shinjiro, Shimizu, Noriaki, Sakamoto, Akihisa, Nagaoka, Katsuya, Takase, Ryuta, Kohrogi, Kensaku, Araki, Hirotaka, Hino, Yuko, Usuki, Shingo, Oki, Shinya, Tanaka, Hirotoshi, Nakamura, Kimitoshi, Endo, Fumio, Nakao, Mitsuyoshi“…Consistent with this, loss of LSD1 activity during differentiation enhanced the oxidative capacity of myotubes. …”
Publicado 2018
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74por Lee, Catherine, Rudneva, Vasilisa A., Erkek, Serap, Zapatka, Marc, Chau, Lianne Q., Tacheva-Grigorova, Silvia K., Garancher, Alexandra, Rusert, Jessica M., Aksoy, Ozlem, Lea, Robin, Mohammad, Helai P., Wang, Jianxun, Weiss, William A., Grimes, H. Leighton, Pfister, Stefan M., Northcott, Paul A., Wechsler-Reya, Robert J.“…We also show that Lsd1 is essential for Gfi1-mediated transformation: Gfi1 proteins that cannot recruit Lsd1 are unable to drive tumorigenesis, and genetic ablation of Lsd1 markedly impairs tumor growth in vivo. …”
Publicado 2019
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75por Preller, Katrin H., Razi, Adeel, Zeidman, Peter, Stämpfli, Philipp, Friston, Karl J., Vollenweider, Franz X.“…To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after acute administration of lysergic acid diethylamide (LSD), and after pretreatment with Ketanserin (a selective serotonin 2A receptor antagonist) plus LSD in a double-blind, randomized, placebo-controlled, cross-over study in 25 healthy participants. …”
Publicado 2019
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76“…Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. …”
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77por Holze, Friederike, Vizeli, Patrick, Müller, Felix, Ley, Laura, Duerig, Raoul, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, Liechti, Matthias E.“…Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, and d-amphetamine is a classic stimulant. …”
Publicado 2019
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78por Tamaoki, Junya, Takeuchi, Miki, Abe, Ryo, Kaneko, Hiroshi, Wada, Taeko, Hino, Shinjiro, Nakao, Mitsuyoshi, Furukawa, Yusuke, Kobayashi, Makoto“…In this study, we investigated the structures and expression of LSD1 splicing variants in zebrafish and found all 4 types of LSD1 isoforms: LSD1, LSD1+2al, LSD1+8al and LSD1+2al8al. …”
Publicado 2020
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79“…Furthermore, LSD1 is overexpressed in various cancers. Therefore, LSD1 inhibitors would be not only potential therapeutic agents for cancers but also chemical tools to research biological significance of LSD1 in physiological and pathological events. …”
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80por Engstrom, Amanda K., Walker, Alicia C., Moudgal, Rohitha A., Myrick, Dexter A., Kyle, Stephanie M., Bai, Yu, Rowley, M. Jordan, Katz, David J.“…Previously, our laboratory implicated the histone demethylase LSD1 in tau-induced neurodegeneration by showing that LSD1 localizes to pathological tau aggregates in Alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. …”
Publicado 2020
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