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921por Yu, Ziliang, Chen, Feihu, Liu, Hao, Fan, Jianbo, Ding, Xiaomin, Zhu, Xinhui, Cui, Shengyu, Yi, Hong, Zhou, Xiaogang, Hu, Yalong, Liu, Wei“…Furthermore, the possible molecular mechanisms were explored by detecting the expression of key factors, including matrix metalloproteinases (MMPs), lysine-specific histone demethylase 1 (LSD1) and associated cytokines, via reverse transcription-quantitative PCR and western blotting. …”
Publicado 2022
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922por Kim, Yang Gyun, Moon, Ju-Young, Oh, Bermseok, Chin, Ho Jun, Kim, Dong Ki, Park, Jung Hwan, Shin, Sung Joon, Choi, Bum Soon, Lim, Chun Soo, Lee, Sang Ho“…Olmesartan reduced BP in both groups, whereas LSD decreased systolic BP only in older participants. …”
Publicado 2022
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923por Sunami, Yoshitaka, Yokoyama, Takashi, Yoshino, Seiko, Takahara, Tomoko, Yamazaki, Yukari, Harada, Hironori, Nakamura, Takuro“…Suppression of the corepressor components HDAC and LSD1 reverses the repressive activity. Moreover, treatment of AML cells with the HDAC inhibitor pracinostat and the LSD1 inhibitor GSK2879552 resulted in growth inhibition in vitro and in vivo. …”
Publicado 2022
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924“…The histone demethylase LSD1 was highly expressed in the tissues of autistic mice and bound to TGIF2 promoter, which was possibly responsible for TGIF2 downregulation. …”
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925por Zhou, Xiaolei, Singh, Madhurendra, Sanz Santos, Gema, Guerlavais, Vincent, Carvajal, Luis A., Aivado, Manuel, Zhan, Yue, Oliveira, Mariana M.S., Westerberg, Lisa S., Annis, D. Allen, Johnsen, John Inge, Selivanova, Galina“…Paradoxically, we found that p53 activated by MDM2 inhibitors induced the expression of endogenous retroviruses (ERV) via increased occupancy on ERV promoters and inhibition of two major ERV repressors, histone demethylase LSD1 and DNA methyltransferase DNMT1. Double-stranded RNA stress caused by ERVs triggered type I/III interferon expression and antigen processing and presentation. …”
Publicado 2021
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926“…LSD post hoc test showed that the mean score of performance was significantly higher immediately after the training program compared to before the intervention and 3 weeks after the SBL (p < 0.001). …”
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927por Garrine, Marcelino, Matambisso, Glória, Nobela, Nélio, Vubil, Delfino, Massora, Sérgio, Acácio, Sozinho, Nhampossa, Tacilta, Alonso, Pedro, Mandomando, Inácio“…DEC were more common among LSD cases (2.7%, [8/297] of cases vs. 1.3% [4/297] of controls; p = 0.243]) than in MSD cases (0%, [0/89] of cases vs. 0.4%, [1/222] of controls; p = 1.000). …”
Publicado 2020
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928por Tabano, Silvia, Tassi, Lorenzo, Cannone, Marta Giulia, Brescia, Gloria, Gaudioso, Gabriella, Ferrara, Mariarosa, Colapietro, Patrizia, Fontana, Laura, Miozzo, Monica Rosa, Croci, Giorgio Alberto, Seia, Manuela, Piuma, Cristina, Solbiati, Monica, Tobaldini, Eleonora, Ferrero, Stefano, Montano, Nicola, Costantino, Giorgio, Buoli, Massimiliano“…Methylation levels at CRHR1, DRD2 and LSD1 genes was significantly higher in cases with respect to controls (p < 0.01, p = 0.03 and p = 0.03, respectively). …”
Publicado 2022
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929por Ding, Ying, Gao, Xiaomin, Zhao, Juanjuan, Zhi, Qiong, Liu, Xin, Zuo, Qisheng, Jin, Kai, Zhang, Yani, Niu, Yingjie, Han, Wei, Song, Jiuzhou, Li, Bichun“…Interestingly, in mechanistic terms, dual luciferase assays showed that TDRD1 transcription levels were significantly decreased after co-transfection with dCas9-LSD1-P1/P2/P3 and OETCF7L2, while TDRD1 transcript levels were not significantly altered after transfecting dCas9-LSD1-P4 and OETCF7L2. …”
Publicado 2023
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930por Singleton, S. Parker, Timmermann, Christopher, Luppi, Andrea I., Eckernäs, Emma, Roseman, Leor, Carhart-Harris, Robin L., Kuceyeski, Amy“…In recent work using a receptor-informed network control theory framework, we demonstrated that the serotonergic psychedelics lysergic acid diethylamide (LSD) and psilocybin flatten the brain’s control energy landscape in a manner that covaries with more dynamic and entropic brain activity. …”
Publicado 2023
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931por Pottie, Eline, Poulie, Christian B. M., Simon, Icaro A., Harpsøe, Kasper, D’Andrea, Laura, Komarov, Igor V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper L., Stove, Christophe P.“…Furthermore, the use of two reference agonists allowed for the estimation of both “benchmark bias” (relative to LSD) and “physiology bias” (relative to serotonin).…”
Publicado 2023
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932“…The levels of serum urea nitrogen and uric acid in pigeons of LSD group increased significantly, while the concentration of total cholesterol and the activity of alanine aminotransferase were higher in the control group. …”
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933por Ibanez, Vinzon, Vaitkus, Kestis, Zhang, Xu, Ramasamy, Jagadeesh, Rivers, Angela E., Saunthararajah, Yogen, Molokie, Robert, Lavelle, Donald“…Pharmacological inhibitors of DNA methyltransferase (DNMT1) and lysine-specific demethylase 1A (LSD1), 2 epigenome-modifying enzymes associated with the multiprotein corepressor complex recruited to the repressed γ-globin gene, are powerful in vivo inducers of HbF. …”
Publicado 2023
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934por Chiu, Yi-Ting, Deutch, Ariel Y., Wang, Wei, Schmitz, Gavin P, Huang, Karen Lu, Kocak, D. Dewran, Llorach, Pierre, Bowyer, Kasey, Liu, Bei, Sciaky, Noah, Hua, Kunjie, Chen, Chongguang, Mott, Sarah E., Niehaus, Jesse, DiBerto, Jeffrey F., English, Justin, Walsh, Jessica J., Scherrer, Grégory, Herman, Melissa A, Wu, Zhuhao, Wetsel, William C, Roth, Bryan L“…LSD and psilocybin exert their psychedelic effects via activation of the 5-hydroxytryptamine 2A receptor (HTR2A). …”
Publicado 2023
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935por Zhong, Xue, Peddada, Nagesh, Wang, Jianhui, Moresco, James J., Zhan, Xiaowei, Shelton, John M., SoRelle, Jeffrey A., Keller, Katie, Lazaro, Danielle Renee, Moresco, Eva Marie Y., Choi, Jin Huk, Beutler, Bruce“…We demonstrate that OVOL2 inhibits the epigenetic regulatory BRAF-HDAC complex, specifically disrupting RCOR1-LSD1 interaction. This causes inhibition of LSD1-mediated H3K4me2 demethylation, resulting in chromatin accessibility and transcriptional activation of epithelial genes. …”
Publicado 2023
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936por López-Tobón, Alejandro, Shyti, Reinald, Villa, Carlo Emanuele, Cheroni, Cristina, Fuentes-Bravo, Patricio, Trattaro, Sebastiano, Caporale, Nicolò, Troglio, Flavia, Tenderini, Erika, Mihailovich, Marija, Skaros, Adrianos, Gibson, William T., Cuomo, Alessandro, Bonaldi, Tiziana, Mercurio, Ciro, Varasi, Mario, Osborne, Lucy, Testa, Giuseppe“…Consistently, inhibition of lysine demethylase 1 (LSD1), a GTF2I effector, was sufficient to rescue ASD-like phenotypes in transgenic mice, establishing GTF2I-LSD1 axis as a molecular pathway amenable to therapeutic intervention in ASD.…”
Publicado 2023
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937“…The results of the automated segmentation were analyzed with an analysis of variance (ANOVA) and uncorrected post hoc least significant difference (LSD) tests using Statistical Package for Social Sciences (SPSS) 17. …”
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938“…Additionally, the software can perform multiple comparisons of means using the Duncan, Student-Newman-Keuls, Tukey Kramer, Westfall, and Fisher’s least significant difference (LSD) tests. If the LSD test is selected, multiple methods (e.g., Bonferroni and Holm) are available for adjusting p-values. …”
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939por Wang, Manli, Fang, Haiqing, Bishwajit, Ghose, Xiang, Yuanxi, Fu, Hang, Feng, Zhanchun“…Analysis of Variance (ANOVA) and Least Significant Difference (LSD) methods were used to measure the RPHC disparities between Western and Eastern and Central China. …”
Publicado 2015
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940por Alfadhel, Majid, Benmeakel, Mohammed, Hossain, Mohammad Arif, Al Mutairi, Fuad, Al Othaim, Ali, Alfares, Ahmed A., Al Balwi, Mohammed, Alzaben, Abdullah, Eyaid, Wafaa“…Organic acidemias were the most common small molecule IEMs, while lysosomal storage disorders (LSD) were the most common large molecule diseases. …”
Publicado 2016
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