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Mostrando 81 - 100 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.34s Limitar resultados
  1. 81
    “…Constitutively increasing LSD1 activity via knocking out its dominant negative splicing isoform neuroLSD1 (neuroLSD1(KO) mice), we observed extensive structural, functional and behavioral signs of excitatory decay, including disrupted memory consolidation. …”
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    LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse
  2. 82
    “…Lysergic acid diethylamide (LSD) is a potent psychedelic drug, which has seen a revival in clinical and pharmacological research within recent years. …”
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    Increased sensitivity to strong perturbations in a whole-brain model of LSD
  3. 83
    por Kim, Dongha, Kim, Keun Il, Baek, Sung Hee
    Publicado 2021
    “…Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. …”
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    Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
  4. 84
    “…LSD1 inhibition prior to macrophage activation with LPS prevents CAT repression by enhancing the LSD1 and interfering with the HDAC1 recruitment to the gene promoter. …”
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    LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase
  5. 85
    “…Here, we evaluated JBI-097 a dual LSD1/HDAC6 inhibitor, for its in vitro and in vivo activities in various tumor models. …”
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    Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer
  6. 86
    “…The individualized Ising temperatures are higher in the LSD condition than in the placebo condition (p = 9 × 10(−5)). …”
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    LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
  7. 87
    “…LSD1 is overexpressed in several cancer types, and chemical inhibition of the LSD1 activity has been proposed as a candidate cancer therapy. …”
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    Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
  8. 88
    por Rosso, E
    Publicado 1972
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    First Digitizations of 12' ANL Bubble Chamber Pictures on CERN LSD2
  9. 89
    “…CONCLUSION: This paper intends to review the research progress in this field from the aspects of histone methylation modification and the protein structure, catalytic mechanism and biological function of the important histone demethylases LSD1 and LSD2, in order to provide the theoretical reference for further understanding and exploration of histone demethylases in development and prognosis of gastric cancer.…”
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    Relationship between histone demethylase LSD family and development and prognosis of gastric cancer
  10. 90
    “…Together, these findings suggests that LSD perturbs the Excitation/Inhibition balance of the brain. …”
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    The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity
  11. 91
    “…LSD1 deletion increases H3K27ac levels and P300 occupancy at LSD1-targeted enhancers. …”
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    Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
  12. 92
    por Snelders, Stephen, Kaplan, Charles
    Publicado 2002
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    LSD therapy in Dutch psychiatry: changing socio-political settings and medical sets.
  13. 93
    Publicado 1983
    “…We investigated the action of LSD at the putative indoleaminergic lateral inhibitory synapse in the lateral eye of Limulus polyphemus. …”
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    Presynaptic uptake blockade hypothesis for LSD action at the lateral inhibitory synapse in Limulus
  14. 94
    “…We show that recruitment of LSD1 at the HIV-1 proximal promoter is associated with both H3K4me3 and H3K9me3 epigenetic marks. …”
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    LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
  15. 95
    “…While there is evidence that Lsd1-interacting proteins regulate the activity and specificity of Lsd1, the significance and roles of such interactions in developmental processes remain largely unknown. …”
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    A Hypomorphic Lsd1 Allele Results in Heart Development Defects in Mice
  16. 96
    “…METHODS: We evaluated the correlation of LSD1, CDH-1 and CDH-2 with invasiveness of colon cancer cells, and investigated the roles of LSD1 in proliferation, invasion and apoptosis of colon cancer cells. …”
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    LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer
  17. 97
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    LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
  18. 98
    “…The present study aimed to investigate the effects of LSD1 knockdown, and the interplay between LSD1 and DDP, on prostate cancer cell proliferation, apoptosis and invasion, and, therefore, the potential of LSD1 as a target for prostate cancer therapy. …”
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    Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells
  19. 99
    “…This paper will present the results of external verification measurements of such LSD spikes performed by the European Commission and the International Atomic Energy Agency.…”
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    Verification measurements of the IRMM-1027 and the IAEA large-sized dried (LSD) spikes
  20. 100
    “…Here we compute these measures for spontaneous magnetoencephalographic (MEG) signals from humans during altered states of consciousness induced by three psychedelic substances: psilocybin, ketamine and LSD. For all three, we find reliably higher spontaneous signal diversity, even when controlling for spectral changes. …”
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    Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin
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