“…A radical innovation is psychedelic-assisted psychotherapy (PAP): professionally supervised use of ketamine, MDMA, psilocybin, LSD and ibogaine as part of elaborated psychotherapy programs. …”
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“…First, in the separating line detection stage, we propose a line-clustering method based on the line segment detection (LSD) algorithm. Our detecting and line-clustering algorithm can detect the separating lines that contain a pair of parallel lines with a fixed distance in a bird’s eye view (BEV) image under diverse lighting and ground conditions. …”
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“…Paired t test was applied and analysis of variance (ANOVA) was used to evaluate the variation of force generated. LSD (Fisher’s least significant difference) post-hoc test was thus employed. …”
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“…Instead, we consider the rate of screen positives as the only currently reliable way to compare LSD NBS results across labs worldwide. It has been suggested that the expression of enzymatic activity data as multiple-of-the-mean is a way to normalize datasets obtained using different assay platforms, so that results can be compared, and universal cutoffs can be developed. …”
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“…This article covers the renaissance of classical psychedelic drugs such as psilocybin and LSD plus 3,4-methylene dioxymethamphetamine (MDMA—ecstasy) in psychiatric research. …”
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“…Schindler disease is an autosomal recessive, inherited LSD caused by defective or non-existent activity of the enzyme α-N-acetylgalactosaminidase (α-NAGA). …”
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“…SUMMARY: Lumpy skin disease (LSD) is an emerging disease in Kazakhstan, and currently the means of transmission is uncertain. …”
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“…Lysosomal storage disorders (LSDs) are characterized by an accumulation of various substances, such as sphingolipids, mucopolysaccharides, and oligosaccharides. The LSD enzymes responsible for the catabolism are active at acidic pH in the lysosomal compartment. …”
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“…Altered sphingolipid metabolism with an accumulation of undigested substrates in lysosomes due to lysosomal enzyme deficiency is linked to lysosomal storage disorders (LSD). Trapping of sphingolipids and their metabolites in the lysosomes inhibits lipid recycling, which has a direct effect on the lipid composition of cellular membranes, including the inner mitochondrial membrane. …”
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“…The data were analyzed with chi-square, one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc tests. RESULTS: At days 1 and 3, preoperative administration of the antihistamine and analgesic resulted in lower pain levels than the placebo. …”
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“…While heterozygous and homozygous mutations in GBA1 are the highest genetic risk factor for PD, studies performed over the past decade have suggested that lysosomal loss of function is likely involved in PD pathology, since a significant percent of PD patients have a mutation in one or more genes that cause a lysosomal storage disease (LSD). Although the mechanistic connection between the lysosome and PD remains somewhat enigmatic, significant evidence is accumulating that lysosomal dysfunction plays a central role in PD pathophysiology. …”
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“…In addition, we show that the layered SD (LSD) method can be applied to our RIBE scheme and a chosen-ciphertext secure RIBE scheme also can be designed generically.…”
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“…These research methods broaden the tools available for LSDV researchers and will facilitate the gathering of evidence to underpin the development of LSD control and prevention programmes.…”
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“…While the vast majority of chromatin-associated complexes are essential for ESC growth, the only complexes that conferred growth advantage upon mutation of their members, were the repressive complexes LSD-CoREST and BHC. Both complexes include the most potent growth-restricting chromatin-related protein, ZMYM2. …”
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“…A literature search of the PubMed/MEDLINE database identified 14 clinical trials from the last 10 years that examined the use of psilocybin, MDMA, DMT, or LSD for the treatment of depression symptoms. Some psychedelics, especially psilocybin, demonstrated an ability to reduce depressive symptoms as measured by several psychological scales, which was often sustained for months after the last psychedelic session. …”
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“…Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease (LSD) in which sphingomyelin accumulates due to deficient acid sphingomyelinase. …”
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“…The absolute indication for the use of sialoendoscopy is mobile calculi less than 5 mm in diameter (L1 according to F. Marchal’s LSD classification). In case of immobile sialoliths less than 4–8 mm in size, located in the main duct (L2), endoscopy should be used as a method supplementary to ductotomy. …”
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“…A chi-squared test, ANOVA, and Fisher’s Post Hoc LSD test were also used to present differences in individual groups. …”
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“…Micro-dosing or acute dosing with psychedelics including Lysergic acid diethylamide (LSD) and psilocybin may offer patients treatment options which are unmet by current therapeutic options. …”
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“…We demonstrate that PCDH19 CTF associates with chromatin and with the chromatin remodeler lysine-specific demethylase 1 (LSD1) and regulates expression of immediate-early genes (IEGs). …”
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