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1101por Hindle, Samantha J., Hebbar, Sarita, Schwudke, Dominik, Elliott, Christopher J.H., Sweeney, Sean T.“…Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life. …”
Publicado 2017
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1102“…Murine models have provided significant insights into our understanding of many LSD mechanisms; however, these systems do not readily permit phenotypic screening of compound libraries, or the establishment of genetic or gene-environment interaction networks. …”
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1103“…Data were analyzed with one-way analysis of variance (ANOVA) and Tukey’s HSD and LSD tests. The level of significance was set at P<0.05. …”
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1104“…The only other reported regularly used substances by males was Ecstasy (1.3%) and by females were LSD (0.5%), Ecstasy (1.5%), Cocaine (0.5%), Inhalants (0.5%) and Ketamine (0.5%). …”
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1105“…As found in many reports, HOXA11-AS can not only act as a molecular scaffold of PRC2, LSD1 and DNMT1 to epigenetically modify chromosomes in the nucleus but also occur as ceRNA competitively sponging miRNAs in the cytoplasm. …”
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1106por Zwergel, Clemens, Romanelli, Annalisa, Stazi, Giulia, Besharat, Zein Mersini, Catanzaro, Giuseppina, Tafani, Marco, Valente, Sergio, Mai, Antonello“…Within this review, we summarize the main preclinical studies regarding epigenetic targets (such as HDAC, SIRT, BET, EZH2, G9a, LSD1, and DNMT) inhibitors in medulloblastoma. Furthermore, we shed light on the increasing number of applications of drug combinations as well as hybrid compounds involving epigenetic mechanisms. …”
Publicado 2018
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1107por Schlotawa, Lars, Dierks, Thomas, Christoph, Sophie, Cloppenburg, Eva, Ohlenbusch, Andreas, Korenke, G. Christoph, Gärtner, Jutta“…Multiple sulfatase deficiency (MSD) is an ultra‐rare lysosomal storage disorder (LSD). Mutations in the SUMF1 gene encoding the formylglycine generating enzyme (FGE) result in an unstable FGE protein with reduced enzymatic activity, thereby affecting the posttranslational activation of newly synthesized sulfatases. …”
Publicado 2019
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1108por Maeda, Mitsuyo, Seto, Toshiyuki, Kadono, Chiho, Morimoto, Hideto, Kida, Sachiho, Suga, Mitsuo, Nakamura, Motohiro, Kataoka, Yosky, Hamazaki, Takashi, Shintaku, Haruo“…Mucopolysaccharidosis type II (MPS II) is a rare lysosomal storage disease (LSD) involving a genetic error in iduronic acid-2-sulfatase (IDS) metabolism that leads to accumulation of glycosaminoglycans within intracellular lysosomes. …”
Publicado 2019
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1109“…We identified 60 SET (HKMTases), 53 JmjC, and 4 LSD (HDMases) genes in B. rapa. The domain composition analysis subcategorized them into seven and nine subgroups, respectively. …”
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1110por Zou, Xiong, Xiao, Changshi, Zhan, Wenqiang, Zhou, Chunhui, Xiu, Supu, Yuan, Haiwen“…Firstly, the initial line segment pool is built by the line segment detector (LSD) algorithm. Then, the coarse-to-fine strategy is used to obtain the onshore line segment pool, including the rough selection of water area instability and the fine selection of the epipolar constraint between image frames, both of which are demonstrated in detail in the text. …”
Publicado 2020
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1111“…We examine published zebrafish LSD models and their reported phenotypes, address organism-specific advantages and limitations, and discuss recent technological innovations that could provide potential solutions.…”
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1112“…Two platforms suitable for multiple LSD screening—tandem mass spectrometry (MS/MS) and digital microfluidic fluorometry (DMF)—are now commercially available with reagent kits. …”
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1113“…Importantly, the administration of GN to HFD groups lowered their body weight and induced a specific upregulation of lipid storage droplet (Lsd)-2 and hormone-sensitive lipase (Hsl), in addition to improved lifespan. …”
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1114por Shuvo, Ikra Iftekhar“…The current study used Plackett-Burman design analysis to optimize the fibre polymer yield (%) during retting Statistical tools including Fisher's LSD, ANOVA, Pearson's correlation coefficient, and principal component analysis (PCA) were applied for a comparative analysis among four different canola cultivars (HYHEAR 1, Topas, 5440, 45H29). …”
Publicado 2021
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1115por Kok, Ken, Zwiers, Kimberley C., Boot, Rolf G., Overkleeft, Hermen S., Aerts, Johannes M. F. G., Artola, Marta“…Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by the deficiency of α-galactosidase A (α-GalA) and the consequent accumulation of toxic metabolites such as globotriaosylceramide (Gb3) and globotriaosylsphingosine (lysoGb3). …”
Publicado 2021
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1116por Bjelica, Dusko, Gardasevic, Jovan, Milosevic, Zoran, Bozic, Predrag R., Masanovic, Bojan“…The descriptive statistics are expressed as the mean and standard deviation for each variable; the analysis of nutrition status was calculated based on BMI, while LSD post hoc testing with ANOVA was employed to investigate differences between the means. …”
Publicado 2021
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1117por Uhlířová, Jana, Šebestová, Lenka, Fišer, Karel, Sieger, Tomáš, Fišerová, Jindřiška, Hozák, Pavel“…We further show that TPR, possibly via lysine-specific demethylase 1 (LSD1), promotes the expression of Myh4 and Olfr376, but not Mef2C. …”
Publicado 2021
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1118“…Scaffolds with large surface depression (2 μm) (LSD), small surface depression (0.37 μm) (SSD), and no surface depression (NSD) were fabricated by using a solvent–nonsolvent system. …”
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1119“…Herein, we employed a targeted NGS-based panel to scan the coding regions of 65 LSD-causative genes. A reference group sample (n = 26) with previously known genetic mutations was used to test and validate the entire workflow. …”
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1120“…Due to its deubiquitinase activity and its ability to team up through direct interactions with several epigenetic regulators, mainly UHRF1, DNMT1, TIP60, the histone lysine methyltransferase EZH2, and the lysine-specific histone demethylase LSD1, HAUSP positions itself at the top of the regulatory hierarchies involved in epigenetic silencing of tumor suppressor genes in cancer. …”
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