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1141por Elwagdy, Salah, Abdelkhalek, Mohamed, El-Kheshen, Abdalla, Aun, Abdel Aziz, Mostafa, Amr“…The amount of pus drained ranged between 3.6 and 29.3 mL (mean: 15.1 mLSD ± 1.5), compatible with the estimated volume by virtual organ computer-aided analysis three-dimensional measurements. …”
Publicado 2015
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1142por Cho, Hyun-Soo, Kang, Jeong Gu, Lee, Jae-Hye, Lee, Jeong-Ju, Jeon, Seong Kook, Ko, Jeong-Heon, Kim, Dae-Soo, Park, Kun-Hyang, Kim, Yong-Sam, Kim, Nam-Soon“…Recently, instead of using the FokI domain, epigenetically active domains, such as TET1 and LSD1, have been combined with TAL effector domains to regulate targeted gene expression via DNA and histone demethylation. …”
Publicado 2015
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1143por Li, Xinran, Rydzewski, Nicholas, Hider, Ahmad, Zhang, Xiaoli, Yang, Junsheng, Wang, Wuyang, Gao, Qiong, Cheng, Xiping, Xu, Haoxing“…Mutations of the lysosomal Ca(2+) channel TRPML1 cause lysosome storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cells. …”
Publicado 2016
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1144por Garrity, Abigail G, Wang, Wuyang, Collier, Crystal MD, Levey, Sara A, Gao, Qiong, Xu, Haoxing“…Furthermore, reducing ER Ca(2+) or blocking IP3Rs caused a dramatic LSD-like lysosome storage phenotype. By closely apposing each other, the ER may serve as a direct and primary source of Ca(2+)for the lysosome. …”
Publicado 2016
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1145“…The results were analyzed using SPSS and repeated measure ANOVA and post hoc least significance (LSD) test (P ≤ 0.05). Results. Among repaired groups it was found that autopolymerized resin reinforced with 2 or 5 wt% nano-zirconia showed the highest transverse strength (P ≤ 0.05). …”
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1146“…During their proliferative phase, follicle progenitors experience Lsd1-dependent changes in epigenetic stability that can be monitored using GAL4::UAS variegation. …”
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1147por López, Elena, García, Sergio, Barea, Rafael, Bergasa, Luis M., Molinos, Eduardo J., Arroyo, Roberto, Romera, Eduardo, Pardo, Samuel“…It allows to improve the results of well-known monocular visual SLAM methods (LSD-SLAM and ORB-SLAM are tested and compared in this work) by solving scale ambiguity and providing additional information to the EKF. …”
Publicado 2017
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1148por Salvalaio, Marika, D’Avanzo, Francesca, Rigon, Laura, Zanetti, Alessandra, D’Angelo, Michela, Valle, Giorgio, Scarpa, Maurizio, Tomanin, Rosella“…In this study, we analyzed the brain of the mouse model for Hunter syndrome, a LSD mostly presenting with neurological involvement. …”
Publicado 2017
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1149por de la Mata, Mario, Cotán, David, Villanueva-Paz, Marina, de Lavera, Isabel, Álvarez-Córdoba, Mónica, Luzón-Hidalgo, Raquel, Suárez-Rivero, Juan M., Tiscornia, Gustavo, Oropesa-Ávila, Manuel“…Gaucher disease (GD), the LSD with the highest prevalence, is caused by mutations in the GBA1 gene that results in defective and insufficient activity of the enzyme β-glucocerebrosidase (GCase). …”
Publicado 2016
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1150por McLoughlin, Mairead, Stepien, Karolina M., McNelly, Briony, Thompson, Lorraine, Gorton, Janet, Hendriksz, Christian J.“…It resulted in producing a leaflet and designing an educational program for our LSD patients.…”
Publicado 2017
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1151por Xu, Yetao, Wu, Dan, Liu, Jie, Huang, Shiyun, Zuo, Qing, Xia, Xi, Jiang, Ying, Wang, Sailan, Chen, Yanzi, Wang, Tianjun, Sun, Lizhou“…Mechanistic analyses showed that HOXA11-AS could recruit Ezh2 and Lsd1 protein and regulate RND3 mRNA expression in the nucleus. …”
Publicado 2018
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1152por Sorrentino, Nicolina Cristina, Cacace, Vincenzo, De Risi, Maria, Maffia, Veronica, Strollo, Sandra, Tedesco, Novella, Nusco, Edoardo, Romagnoli, Noemi, Ventrella, Domenico, Huang, Yan, Liu, Nan, Kalled, Susan L., Choi, Vivian W., De Leonibus, Elvira, Fraldi, Alessandro“…Mucopolysaccharidosis type IIIA (MPS-IIIA) is a lysosomal storage disorder (LSD) caused by inherited defect of sulfamidase, a lysosomal sulfatase. …”
Publicado 2019
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1153“…A recent study suggested that methylation of ubiquitin-like with PHD and RING finger domain 1 (UHRF1) is regulated by SET7 and lysine-specific histone demethylase 1A (LSD1) and is essential for homologous recombination (HR). …”
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1154por Puentes-Tellez, María Alejandra, Lerma-Barbosa, Paula Andrea, Garzón-Jaramillo, Rafael Guillermo, Suarez, Diego A., Espejo-Mojica, Angela J., Guevara, Johana M., Echeverri, Olga Yaneth, Solano-Galarza, Daniela, Uribe-Ardila, Alfredo, Alméciga-Díaz, Carlos J.“…Noteworthy, implementation of the enzyme assay in dried blood samples, led to a 5-fold increase in the identification of LSD patients, suggesting that these disorders still remain undiagnosed in the country. …”
Publicado 2020
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1155por Monaco, Antonio, Maffia, Veronica, Sorrentino, Nicolina Cristina, Sambri, Irene, Ezhova, Yulia, Giuliano, Teresa, Cacace, Vincenzo, Nusco, Edoardo, De Risi, Maria, De Leonibus, Elvira, Schrader, Thomas, Klärner, Frank-Gerrit, Bitan, Gal, Fraldi, Alessandro“…Together, these data provide evidence that brain deposition of amyloid proteins plays a gain of neurotoxic function in a severe LSD by affecting the ALP and identify CLR01 as new potent drug candidate for MPS-IIIA and likely for other LSDs.…”
Publicado 2020
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1156“…A third child of consanguineal parents showed several dysmorphic features and a complicated neonatal period with eventual demise in the early postneonatal period due to respiratory failure. An LSD was suspected based on clinical presentation, urine metabolite excretion, skeletal radiograph, and vacuolisation in lymphocytes and placental tissues on, respectively, blood smear and routine histological examination. …”
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1157por Chiang, Shu-Chuan, Chen, Pin-Wen, Hwu, Wuh-Liang, Lee, An-Ju, Chen, Li-Chu, Lee, Ni-Chung, Chiou, Li-Yan, Chien, Yin-Hsiu“…The National Taiwan University Hospital Newborn Screening Center launched the four-plex tandem mass spectrometry LSD newborn screening test in 2015. The test determined activities of acid α-glucosidase (GAA; Pompe), acid α-galactosidase (GLA; Fabry), acid β-glucocerebrosidase (ABG; Gaucher), and acid α-l-iduronidase (IDUA; MPS-I) in dried blood spots (DBS). …”
Publicado 2018
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1158por Safari, Zahra, Fouladi-Fard, Reza, Vahidmoghadam, Razieh, Hosseini, Mohammad Raza, Mohammadbeigi, Abolfazl, Omidi Oskouei, Alireza, Rezaali, Mostafa, Ferrante, Margherita, Fiore, Maria“…In addition, the results of ANOVA (LSD—least significant difference) showed that there was a significant difference (p < 0.05) between district 7—with lower mean scores in awareness and performance—and other districts. …”
Publicado 2021
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1159por Wikiera, Agnieszka, Grabacka, Maja, Byczyński, Łukasz, Stodolak, Bożena, Mika, Magdalena“…The analyses were performerd in tetraplicates and the statistical significance of the differences were assessed using ANOVA, Tukey post hoc and LSD (the least significant difference) tests. Multivariate regression analysis was applied to determine the structural components that have a crucial importance for antioxidant and antitumor properties of pectins. …”
Publicado 2021
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1160por Rigon, Laura, De Filippis, Concetta, Napoli, Barbara, Tomanin, Rosella, Orso, Genny“…In the last twenty years, different LSD Drosophila models have been generated, mainly for diseases presenting with neurological involvement. …”
Publicado 2021
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