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101por Myrick, Dexter A., Christopher, Michael A., Scott, Alyssa M., Simon, Ashley K., Donlin-Asp, Paul G., Kelly, William G., Katz, David J.“…Here, we investigated the function of the H3K4me2 demethylase KDM1A/LSD1 during spermatogenesis in developing and adult mice. …”
Publicado 2017
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102“…The LSD1 histone demethylase is highly expressed in breast tumors where it constitutes a factor of poor prognosis and promotes traits of cancer aggressiveness such as cell invasiveness. …”
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103por Tosic, Milica, Allen, Anita, Willmann, Dominica, Lepper, Christoph, Kim, Johnny, Duteil, Delphine, Schüle, Roland“…Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 directly regulates key myogenic transcription factor genes. …”
Publicado 2018
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104“…LSD1 binds to the promoter region of the SESN2 gene, where LSD1-mediated demethylation leads to the accumulation of repressive histone marks that maintain SESN2 expression at low levels. …”
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105“…RESULTS: The deubiquitinase USP38 stabilizes protein LSD1 in cells by binding LSD1 and cleaving its ubiquitin chain to prevent the degradation of LSD1 by the intracellular proteasome. …”
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106“…Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. …”
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107por Li, Zhonghai, Zhang, Yang, Zou, Dong, Zhao, Yi, Wang, Hou-Ling, Zhang, Yi, Xia, Xinli, Luo, Jingchu, Guo, Hongwei, Zhang, Zhang“…Through manual curation and extensive annotation, we updated the LSD to a new version LSD 3.0, which contains 5853 genes and 617 mutants from 68 species. …”
Publicado 2020
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108por Beilner, Daniel, Kuhn, Christina, Kost, Bernd P., Jückstock, Julia, Mayr, Doris, Schmoeckel, Elisa, Dannecker, Christian, Mahner, Sven, Jeschke, Udo, Heidegger, Helene Hildegard“…PURPOSE: Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. …”
Publicado 2020
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109por Leiendecker, Lukas, Jung, Pauline S, Krecioch, Izabela, Neumann, Tobias, Schleiffer, Alexander, Mechtler, Karl, Wiesner, Thomas, Obenauf, Anna C“…We show that LSD1 inhibition in MCC disrupts the LSD1‐CoREST complex leading to displacement and degradation of HMG20B (BRAF35), a poorly characterized complex member that is essential for MCC proliferation. …”
Publicado 2020
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110por Cao, Yang, Tang, Lingyi, Du, Kang, Paraiso, Kitt, Sun, Qiushi, Liu, Zhengxia, Ye, Xiaolong, Fang, Yuan, Yuan, Fang, Chen, Hank, Chen, Yumay, Wang, Xiaorong, Yu, Clinton, Blitz, Ira L., Wang, Ping H., Huang, Lan, Cheng, Haibo, Lu, Xiang, Cho, Ken W.Y., Seldin, Marcus, Fang, Zhuyuan, Yang, Qin“…Here, we show that histone demethylase LSD1 KO from adult mouse liver (LSD1-LKO) reduces the expression of one-third of all nuclear-encoded mitochondrial genes and decreases mitochondrial biogenesis and function. …”
Publicado 2021
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111por Sacilotto, Natalia, Dessanti, Paola, Lufino, Michele M. P., Ortega, Alberto, Rodríguez-Gimeno, Alejandra, Salas, Jordi, Maes, Tamara, Buesa, Carlos, Mascaró, Cristina, Soliva, Robert“…A host of classical amine oxidase inhibitors such as tranylcypromine, pargyline, and phenelzine together with LSD1 tool compounds such as SP-2509 and GSK-LSD1 have been extensively utilized in LSD1 mechanistic cancer studies. …”
Publicado 2021
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112por Gahan, James M., Kouzel, Ian U., Jansen, Kamilla Ormevik, Burkhardt, Pawel, Rentzsch, Fabian“…Using the cnidarian Nematostella vectensis as a basal metazoan model, we explore the function of one such chromatin regulator, Lysine specific demethylase 1 (Lsd1). We generated an endogenously tagged allele and show that NvLsd1 expression is developmentally regulated and higher in differentiated neural cells than their progenitors. …”
Publicado 2022
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113por Rummukainen, Petri, Tarkkonen, Kati, Dudakovic, Amel, Al-Majidi, Rana, Nieminen-Pihala, Vappu, Valensisi, Cristina, Hawkins, R. David, van Wijnen, Andre J., Kiviranta, Riku“…Importantly, inhibition of Lsd1 activity decreased osteoblast activity in vivo. …”
Publicado 2022
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114por Fioravanti, Rossella, Rodriguez, Veronica, Caroli, Jonatan, Chianese, Ugo, Benedetti, Rosaria, Di Bello, Elisabetta, Noce, Beatrice, Zwergel, Clemens, Corinti, Davide, Viña, Dolores, Altucci, Lucia, Mattevi, Andrea, Valente, Sergio, Mai, Antonello“…Western blot analyses showed increased levels of H3K4me2 and/or H3K9me2 confirming the involvement of LSD1 inhibition in these assays.…”
Publicado 2022
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115por Bottner, Justus, Ribbat-Idel, Julika, Klapper, Luise, Jagomast, Tobias, Lemster, Anna-Lena, Perner, Sven, Idel, Christian, Kirfel, Jutta“…Previous studies of the prognostic value of LSD1 in HNSCC have been limited in their analysis of sub-sites, and a correlation between LSD1 and SNAIL has not been shown in HNSCC patient samples. …”
Publicado 2022
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116por Müller, Felix, Kraus, Elias, Holze, Friederike, Becker, Anna, Ley, Laura, Schmid, Yasmin, Vizeli, Patrick, Liechti, Matthias E., Borgwardt, Stefan“…BACKGROUND: LSD and psilocybin are increasingly used in phase I trials and evaluated as therapeutic agents for mental disorders. …”
Publicado 2022
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117por Rapanelli, Maximiliano, Williams, Jamal B., Ma, Kaijie, Yang, Fengwei, Zhong, Ping, Patel, Rajvi, Kumar, Manasa, Qin, Luye, Rein, Benjamin, Wang, Zi-Jun, Kassim, Bibi, Javidfar, Behnam, Couto, Lizette, Akbarian, Schahram, Yan, Zhen“…Concomitantly, LSD1 inhibition restores NMDA receptor function in PFC and mEPSCs in striatum of Shank3-deficient mice. …”
Publicado 2022
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118“…MATERIALS AND METHODS: Heart tissues from young mice and elder mice were collected for immunohistochemical staining. LSD1 in 3T3-L1 cells was knocked down by LSD1-shRNA lentivirus infection. …”
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119“…Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. …”
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