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Mostrando 101 - 120 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.16s Limitar resultados
  1. 101
    “…Here, we investigated the function of the H3K4me2 demethylase KDM1A/LSD1 during spermatogenesis in developing and adult mice. …”
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    KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice
  2. 102
    “…The LSD1 histone demethylase is highly expressed in breast tumors where it constitutes a factor of poor prognosis and promotes traits of cancer aggressiveness such as cell invasiveness. …”
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    ERRα protein is stabilized by LSD1 in a demethylation-independent manner
  3. 103
    “…Here, we show that elevated levels of lysine-specific demethylase 1 (Kdm1a, also known as Lsd1) have a beneficial effect on muscle regeneration and recovery after injury, since Lsd1 directly regulates key myogenic transcription factor genes. …”
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    Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
  4. 104
    por Ambrosio, Susanna, Majello, Barbara
    Publicado 2018
    “…LSD1 binds to the promoter region of the SESN2 gene, where LSD1-mediated demethylation leads to the accumulation of repressive histone marks that maintain SESN2 expression at low levels. …”
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    Targeting Histone Demethylase LSD1/KDM1a in Neurodegenerative Diseases
  5. 105
    “…RESULTS: The deubiquitinase USP38 stabilizes protein LSD1 in cells by binding LSD1 and cleaving its ubiquitin chain to prevent the degradation of LSD1 by the intracellular proteasome. …”
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    The deubiquitinase USP38 affects cellular functions through interacting with LSD1
  6. 106
    por Fang, Yuan, Liao, Guochao, Yu, Bin
    Publicado 2019
    “…Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. …”
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    LSD1/KDM1A inhibitors in clinical trials: advances and prospects
  7. 107
    “…Through manual curation and extensive annotation, we updated the LSD to a new version LSD 3.0, which contains 5853 genes and 617 mutants from 68 species. …”
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    LSD 3.0: a comprehensive resource for the leaf senescence research community
  8. 108
    “…PURPOSE: Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. …”
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    Lysine-specific histone demethylase 1A (LSD1) in cervical cancer
  9. 109
    “…We show that LSD1 inhibition in MCC disrupts the LSD1‐CoREST complex leading to displacement and degradation of HMG20B (BRAF35), a poorly characterized complex member that is essential for MCC proliferation. …”
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    LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma
  10. 110
    “…Here, we show that histone demethylase LSD1 KO from adult mouse liver (LSD1-LKO) reduces the expression of one-third of all nuclear-encoded mitochondrial genes and decreases mitochondrial biogenesis and function. …”
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    Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1
  11. 111
    “…A host of classical amine oxidase inhibitors such as tranylcypromine, pargyline, and phenelzine together with LSD1 tool compounds such as SP-2509 and GSK-LSD1 have been extensively utilized in LSD1 mechanistic cancer studies. …”
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    Comprehensive in Vitro Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology
  12. 112
    “…Using the cnidarian Nematostella vectensis as a basal metazoan model, we explore the function of one such chromatin regulator, Lysine specific demethylase 1 (Lsd1). We generated an endogenously tagged allele and show that NvLsd1 expression is developmentally regulated and higher in differentiated neural cells than their progenitors. …”
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    Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
  13. 113
    “…Importantly, inhibition of Lsd1 activity decreased osteoblast activity in vivo. …”
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    Lysine-Specific Demethylase 1 (LSD1) epigenetically controls osteoblast differentiation
  14. 114
    “…Western blot analyses showed increased levels of H3K4me2 and/or H3K9me2 confirming the involvement of LSD1 inhibition in these assays.…”
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    Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
  15. 115
    “…Previous studies of the prognostic value of LSD1 in HNSCC have been limited in their analysis of sub-sites, and a correlation between LSD1 and SNAIL has not been shown in HNSCC patient samples. …”
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    Elevated LSD1 and SNAIL Expression Indicate Poor Prognosis in Hypopharynx Carcinoma
  16. 116
    “…BACKGROUND: LSD and psilocybin are increasingly used in phase I trials and evaluated as therapeutic agents for mental disorders. …”
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    Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants
  17. 117
    “…Concomitantly, LSD1 inhibition restores NMDA receptor function in PFC and mEPSCs in striatum of Shank3-deficient mice. …”
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    Targeting Histone Demethylase LSD1 for Treatment of Deficits in Autism Mouse Models
  18. 118
    “…MATERIALS AND METHODS: Heart tissues from young mice and elder mice were collected for immunohistochemical staining. LSD1 in 3T3-L1 cells was knocked down by LSD1-shRNA lentivirus infection. …”
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    LSD1 in beige adipocytes protects cardiomyocytes against oxygen and glucose deprivation
  19. 119
    “…Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. …”
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    LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions
  20. 120
    por Ghesquière, Claude
    Publicado 1972
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    Measurement on LSD of p.bar.p -> 4 Prongs at Rest. Comparison with HPD Measurements
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