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Mostrando 121 - 140 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.18s Limitar resultados
  1. 121
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    [Retracted] Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells
  2. 122
    “…We then show how the quasi-eigenvectors can be used for Latent Spectral Decomposition (LSD). We apply LSD to denoise MNIST images. Finally, using the quasi-eigenvectors, we construct rotation matrices in latent space which map to feature transformations in real space. …”
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    Using deep LSD to build operators in GANs latent space with meaning in real space
  3. 123
    “…The histone demethylase Lsd1 has been shown to play multiple essential roles in mammalian biology. …”
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    Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses
  4. 124
    “…As one of the crucial targets of epigenetics, histone lysine-specific demethylase 1 (LSD1) is significant in the occurrence and development of various tumors. …”
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    LSD1-Based Reversible Inhibitors Virtual Screening and Binding Mechanism Computational Study
  5. 125
    “…This review examines how LSD1 modulates different cell behavior in TME and emphasizes the potential use of LSD1 inhibitors in combination with ICB therapy for future cancer research studies.…”
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    LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy
  6. 126
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    Skp2 is a novel regulator of LSD1 expression and function in gastric cancer
  7. 127
    “…We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR). We show that LSD1 is recruited directly to sites of DNA damage. …”
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    The histone demethylase LSD1/KDM1A promotes the DNA damage response
  8. 128
    “…These results indicate a great potential of the new lsd90 promoter-based vector for commercial scale expression of therapeutic proteins in S. pombe.…”
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    High Level Constitutive Expression of Luciferase Reporter by lsd90 Promoter in Fission Yeast
  9. 129
    “…We examine here the role of extranucleosomal DNA beyond the nucleosome core particle for LSD1/CoREST function. Our studies of LSD1/CoREST's enzyme activity and nucleosome binding show that extranucleosomal DNA dramatically enhances the activity of LSD1/CoREST, and that LSD1/CoREST binds to the nucleosome as a 1:1 complex. …”
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    Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex
  10. 130
    “…RESULTS: In this study, we showed that LSD1 regulates the expression of GATA-2 during erythroid differentiation. …”
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    Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation
  11. 131
    “…The prognostic value of lysine-specific demethylase 1 (LSD1) overexpression in various cancers has been investigated by many studies with inconsistent results. …”
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    Prognostic role of LSD1 in various cancers: evidence from a meta-analysis
  12. 132
    “…How specific cofactors guide histone demethylase LSD1/KDM1A complex to regulate distinct NSC-related gene activation and repression in cortical neurogenesis remains unclear. …”
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    LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
  13. 133
    “…The function of Lsd1 as a regulator of lipolysis in Drosophila has been demonstrated, as the Lsd1 mutant causes an increase of lipid droplet size. …”
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    Function of Lipid Storage Droplet 1 (Lsd1) in Wing Development of Drosophila melanogaster
  14. 134
    “…High LSD1 expression is observed in Ewing sarcoma patient samples and mechanistic and preclinical data suggest LSD1 inhibition globally disrupts the function of EWS-ETS proteins.…”
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    Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
  15. 135
    “…Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research. …”
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    Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
  16. 136
    por Lin, Jean Z., Farmer, Stephen R.
    Publicado 2016
    “…In this issue of Genes & Development, Zeng and colleagues (pp. 1822–1836) identify lysine-specific demethylase 1 (LSD1) as a pivotal regulator of whole-body energy expenditure by controlling the oxidative and thermogenic activity of brown adipose tissue (BAT). …”
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    LSD1—a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis
  17. 137
    “…d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. …”
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    d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology
  18. 138
    “…BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. …”
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    Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis
  19. 139
    “…Here we show that deletion or enzymatic inactivation of lysine-specific demethylase 1 (Lsd1) triggers senescence in trophoblast stem cells (TSCs). …”
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    Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
  20. 140
    “…Lysergic acid diethylamide (LSD) induces profound changes in various mental domains, including perception, self-awareness and emotions. …”
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    Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects
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