“…Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that NF-κB was largely trapped in lipid droplets (LDs) in the cytoplasm of the NPC-derived cells, while the increased expression of lysine-specific histone demethylase 1 (LSD1, a repressive nuclear factor) reduces the response mediated by remaining NF-κB at the promoters responding to inflammatory stimuli. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through experiments on 60 images covering different complex image backgrounds, the performance of the proposed method far exceeds that of commonly used methods such as LSD, Yolact++, and Mask RCNN. DSC(PL), TPR, precision, and accuracy are as high as 73.95, 81.75, 69.28, and 99.15, respectively, while FDR is only 30.72. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…HOTAIR acts as a ceRNA for several miRNAs and it directly interacts with chromatin remodelling complexes (e.g. PRC2 and LSD1/NuRD complexes). In this regard, we recently reported the transcription factor SNAIL-mediated recruitment of HOTAIR/PRC2 complex on specific chromatin sites causing epithelial genes’ repression through epigenetic chromatin modifications. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The majority of students (71.7%) reported that their studies negatively impacted their emotional condition. 14.5% of all students thought that they needed a consultation by mental health specialist, but decided not to seek help. 11.2% of students reported having used psychotropic drugs which had not been officially prescribed by a psychiatrist. 18.4% of all students thought that seeing a mental health specialist could negatively affect their future career as a doctor. 30.9% of students reported that they had used alcohol to improve their emotional state, 11.2% of students had used cannabis, 4.6% of students had used other drugs (e.g. LSD, amphetamine, cocaine) for this purpose. CONCLUSIONS: 1. …”
Enlace del recurso
Enlace del recurso

“…Although TRPML1 activation has shown rescue effects on LSD phenotypes, its activity is pH dependent, and it is blocked by sphingomyelin accumulation, which is characteristic of some LSDs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5‐HT(2A) receptors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Data were analyzed using descriptive (mean and standard deviation) and analytical statistics (ANOVA, LSD, post hoc test, and paired t-test). The level of statistical significance was p ≤ 0.05. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study used analysis of variance (ANOVA) with two factors and a post hoc test (multiple comparisons - least significant difference (LSD) test) for statical analysis. For determining survival time, the Mantel-Cox test and Kaplan-Meier survival curves were used. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results were statistically assessed using one-way analysis of variance (ANOVA) and LSD t-test. Results: Positive adenovirus PCR was detected in 2.5% and 20% of normal and T1D children, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Curcumin and DMC inhibited the HKMTs enzymes that target the H3K4, H3K9 and H3K27 marks and increased the activity of the HKDMs enzymes LSD1, JARID and JMJD2. In conclusion, we identified novel enzymatic targets for both curcumin and DMC that support their use and development as epigenetic modifiers in cancer treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The predictors that increased RD were consistent condom use with casual partners (aOR = 3.8 [CI 95:1.5–11.0]), the use of Growler to meet partners (aOR = 10.38 [CI 95:161–121.94]), frequenting gay bars (aOR = 1.9 [95% CI:1.1–3.5]) and using LSD (aOR = 5.44 [CI 95:1.32–30.29]). Underestimation of HIV risk in YMSM is associated with standard HIV risk behavior and modulated by psychosocial aspects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and addiction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca). The acute effects of these compounds are well-known as are their ability to increase the emotional state both in healthy people and in those with neuropsychiatric disorders. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…VadH also participates in regulating the genes, mat2, ppgA and lsdA, etc., related to sexual development, and some of the genes in the ST biosynthetic gene cluster. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We identified hallucinogen use based on the survey questions, exploring the use of hallucinogens (LSD, PCP, mescaline, and mushrooms). (3) Results: Out of a total of 125,550 respondents, 8.4% reported using hallucinogens. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The method of the 20 m shuttle run test (20 m SRT) test was used to derive VO(2max) by equation. One-way ANOVA and LSD methods were conducted, and effect sizes were calculated to compare the CRF of the three types of adolescents. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recently, we identified L3MBTL3 as a bona fide RBPJ-binding corepressor that recruits the repressive lysine demethylase LSD1/KDM1A to Notch target genes. Here, we define the RBPJ-interacting domain of L3MBTL3 and report the 2.06 Å crystal structure of the RBPJ–L3MBTL3–DNA complex. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The geoaccumulation index (I(geo)), enrichment factor (EF), and contamination factor (CF), including the pollution load index (PLI), were used for statistical analyses by one-way analysis of variance (ANOVA), and differences in the data were compared using the least significant difference (LSD) test. The sediment heavy metal concentrations were found to decrease (Al > Mn > Pb > Ni > Cd > As), and the quantity of heavy metal contamination in the sediment was not over the emergency point defined by the Pollution Control Department in Thailand. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our genome-wide and gene-specific characterization revealed that, instead of directly repressing STAT6, chromatin-bound GPS2 cooperates with SMRT and NCOR to antagonize enhancer activation by lysine demethylase 1A (KDM1A, LSD1). Mechanistically, corepressor depletion increased KDM1A recruitment to enhancers linked to IL4-induced genes, accompanied by demethylation of the repressive histone marks H3K9me2/3 without affecting H3K4me1/2, the classic KDM1A substrates for demethylation in other cellular contexts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso