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Mostrando 141 - 160 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.18s Limitar resultados
  1. 141
    “…Intriguingly, RORα2 and LSD1 protein levels are dramatically elevated in human breast cancer specimens compared to normal counterparts. …”
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    RORα2 requires LSD1 to enhance tumor progression in breast cancer
  2. 142
    “…The LSD-induced increase in primary index was positively correlated with LSD-induced disembodiment (p < 0.05, Bonferroni-corrected), and blissful state (p < 0.05, Bonferroni-corrected) on the 5D-ASC. …”
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    LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation
  3. 143
    “…METHOD: 100 μg LSD was administrated orally to 20 healthy participants prior to fMRI assessment. …”
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    Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
  4. 144
    “…Mutation in LSD ONE LIKE2 (LOL2) revealed a pattern of susceptibility to H. schachtii antagonistic to lsd1. …”
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    The Role of Programmed Cell Death Regulator LSD1 in Nematode-Induced Syncytium Formation
  5. 145
    “…In this study we show that detectable reactive oxygen species (ROS) are also generated in response to DNA damage by the chromatin remodeling factor and monoamine oxidase LSD1/KDM1A. This raised the possibility that the localized generation of hydrogen peroxide produced by LSD1 may affect the function of proximally located DNA repair proteins. …”
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    LSD1 mediated changes in the local redox environment during the DNA damage response
  6. 146
    “…Epigenetic perturbations are an established hallmark of human MB and expression of Lysine Specific Demethylase 1 (LSD1) is elevated in MBs compared to normal tissue, suggesting that LSD1 inhibitors may have efficacy against human MB tumors. …”
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    Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
  7. 147
    “…Moreover, LSD1 promoted cell proliferation, migration and invasion of GC. …”
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    Upregulation of LSD1 promotes migration and invasion in gastric cancer through facilitating EMT
  8. 148
    “…RareLSD is a manually curated database of lysosomal enzymes associated with rare diseases that maintains comprehensive information of 63 unique lysosomal enzymes and 93 associated disorders. …”
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    RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases
  9. 149
    “…LSD was used in the treatment of anxiety, depression, psychosomatic diseases and addiction. …”
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    Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials
  10. 150
    “…We used structures of H3 substrate analogues bound to LSD1 to design macrocyclic peptide inhibitors of LSD1. …”
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    Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
  11. 151
    “…Previous research reported that lysine-specific histone demethylase 1 (LSD1) maintains cancer stemness through up-regulating stemness markers SOX2 and OCT4. …”
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    Knocking down LSD1 inhibits the stemness features of colorectal cancer stem cells
  12. 152
    “…Lsd1 S112A knock-in (Lsd1(SA/SA)) mice, harboring a deficiency in phosphorylation by PKCα, exhibited less severe colitis symptoms and a relatively intact colonic epithelial lining in dextran sulfate sodium (DSS)-induced colitis models. …”
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    Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium
  13. 153
    “…We found in this study that LSD1 is highly upregulated in bladder cancer specimens, especially those underwent chemotherapy, and the elevated levels of LSD1 are highly associated with bladder cancer grades, metastasis status, and prognosis. …”
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    LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT
  14. 154
    “…We found that lysine-specific demethylase 1A (Kdm1a/Lsd1) is absolutely required for Paneth cell differentiation. …”
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    LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
  15. 155
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    Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer
  16. 156
    “…Loss of LSD1 in Prx1 lineage cells severely impaired bone fracture healing. …”
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    Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing
  17. 157
    por Hoyer-Fender, Sigrid
    Publicado 2020
    “…LSD1 is therefore essential for heterochromatin formation and spreading. …”
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    Transgenerational effect of drug-mediated inhibition of LSD1 on eye pigment expression in Drosophila
  18. 158
    “…The findings demonstrated an increase in BDNF blood plasma levels at 4 h (5 μg) and 6 h (5 and 20 μg) compared to that for the placebo. The finding that LSD acutely increases BDNF levels warrants studies in patient populations.…”
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    Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
  19. 159
    “…The antisense SET7/9 expression vector and the overexpressed LSD1 plasmid were used for transient transfection of LO2 cells. …”
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    Roles of SET7/9 and LSD1 in the Pathogenesis of Arsenic-induced Hepatocyte Apoptosis
  20. 160
    “…The 5-HT2AR antagonist MDL100907 (MDL) blocks the LSD effects. LSD also disrupts prepulse inhibition (PPI) in WT and βArr1-KOs, but not in βArr2-KOs. …”
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    LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
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