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Abuso de drogas
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161por Li, Yan, Qian, Xinying, Lin, Yiyun, Tao, Lei, Zuo, Zeping, Zhang, Huaqin, Yang, Shengyong, Cen, Xiaobo, Zhao, Yinglan“…However, the effect of LSD1 on lipid metabolism remains unclear. In the present study, we used a LC-MS/MS-based lipidomics approach to investigate the impact of LSD1 on cancer cell lipid metabolism using ZY0511, a specific LSD1 inhibitor developed by our group as a specific probe. …”
Publicado 2021
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162“…Compound L8 as a selective and reversible LSD1 inhibitor could inhibit LSD1 with the IC(50) value of 60 nM. …”
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163por Shi, Ying, Wu, Yan-Ran, Su, Ming-Bo, Shen, Dong-Hao, Gunosewoyo, Hendra, Yang, Fan, Li, Jia, Tang, Jie, Zhou, Yu-Bo, Yu, Li-Fang“…Herein we describe the design, synthesis, and biological evaluation of a novel series of tranylcypromine-based LSD1 inhibitors via conformational restriction using spiro ring systems. …”
Publicado 2018
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164por He, Xin, Zhang, Baojing, Cao, Peng, Wang, Honglei, Wu, Shan, Wang, Gang, Yang, Fangyu, Leng, Aijing, Liang, Guobiao, Li, Dawei“…In addition, metabolite 1 showed significant inhibitory effect on lysine-specific demethylase 1 (LSD1) (IC(50) 1.99 μM). Therefore, the biotransformation of dihydrocapsaicin by intestinal fungi afforded various derivatives, which were important resources for developing LSD1 inhibitors and potential application in cancer treatment.…”
Publicado 2022
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165por Araki, Hirotaka, Hino, Shinjiro, Anan, Kotaro, Kuribayashi, Kanji, Etoh, Kan, Seko, Daiki, Takase, Ryuta, Kohrogi, Kensaku, Hino, Yuko, Ono, Yusuke, Araki, Eiichi, Nakao, Mitsuyoshi“…Using skeletal muscle-specific LSD1-knockout mice and in vitro approaches, we found that LSD1 loss exacerbated glucocorticoid-induced atrophy in the fast fiber-dominant muscles, with reduced nuclear retention of Foxk1, an anti-autophagic transcription factor. …”
Publicado 2023
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166“…From SY to F6 follicles, 190 phosphorylation sites of 149 proteins changed significantly, among which the phosphorylation level of lysine demethylase 1 A (LSD1) at the conserved 54(th) serine (LSD1Ser54p) was significantly upregulated in F6 follicles compared to SY follicles (p < 0.05); however, the expression of chicken LSD1 were not significantly different on both mRNA and protein levels. …”
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167Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45Bpor Sang, Na, Zhong, Xi, Gou, Kun, Liu, Huan, Xu, Jing, Zhou, Yang, Zhou, Xia, Liu, Yuanzhi, Chen, Zhiqian, Zhou, Yue, Li, Yan, Tao, Lei, Su, Na, Zhou, Lingyun, Qiu, Jiahao, Yang, Xinyu, Zuo, Zeping, Fu, Li, Zhang, Jingyao, Li, Dan, Li, Cong, Sun, Qingxiang, Lei, Jian, Li, Rui, Yang, Shengyong, Cen, Xiaobo, Zhao, Yinglan“…Lysine‐specific histone demethylase 1 (LSD1) is an attractive target for malignancies therapy. …”
Publicado 2023
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168por Opel, Michael, Lando, David, Bonilla, Carolina, Trewick, Sarah C., Boukaba, Abdelhalim, Walfridsson, Julian, Cauwood, James, Werler, Petra J.H., Carr, Antony M., Kouzarides, Tony, Murzina, Natalia V., Allshire, Robin C., Ekwall, Karl, Laue, Ernest D.“…In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two S. pombe proteins, which we name Swm1 and Swm2 (after SWIRM1 and SWIRM2), associate together in a complex. …”
Publicado 2007
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169“…RATIONALE: Compounds that activate the 5-HT(2A) receptor, such as lysergic acid diethylamide (LSD), act as hallucinogens in humans. One notable exception is the LSD congener lisuride, which does not have hallucinogenic effects in humans even though it is a potent 5-HT(2A) agonist. …”
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170por Kong, Xiangqian, Ouyang, Sisheng, Liang, Zhongjie, Lu, Junyan, Chen, Liang, Shen, Bairong, Li, Donghai, Zheng, Mingyue, Li, Keqin Kathy, Luo, Cheng, Jiang, Hualiang“…Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a flavin-dependent amine oxidase which specifically demethylates mono- or dimethylated H3K4 and H3K9 via a redox process. …”
Publicado 2011
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171por Eliazer, Susan, Palacios, Victor, Wang, Zhaohui, Kollipara, Rahul K., Kittler, Ralf, Buszczak, Michael“…Lsd1 does not directly target the dpp locus in escort cells. …”
Publicado 2014
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172por Kim, Jeesun, Singh, Anup Kumar, Takata, Yoko, Lin, Kevin, Shen, Jianjun, Lu, Yue, Kerenyi, Marc A., Orkin, Stuart H., Chen, Taiping“…Consequently, most Lsd1-null oocytes fail to complete meiosis I and undergo apoptosis. …”
Publicado 2015
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173por Ma, Lin, Ma, Shan, Zhao, Guimei, Yang, Longqiu, Zhang, Peng, Yi, Qingting, Cheng, Shuguang“…In this study, we found that forced the expression of miR‐708 in breast cancer cell lines decreased cell proliferation and invasion, whereas inhibition of miR‐708 increased cell growth and invasion. miR‐708 could directly target the LSD1 3′UTR to downregulate the expression. Further studies suggested that inhibition of LSD1 could phenocopied function of the miR‐708 overexpression in MDA‐MB‐231 cells .Overexpression of LSD1 could counteract the effects of miR‐708 on the proliferation and invasion. …”
Publicado 2016
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174“…PURPOSE: This study aims to identify downstream target genes regulated by lysine-specific demethylase 1 (LSD1) in colon cancer cells and investigate the molecular mechanisms of LSD1 influencing invasion and metastasis of colon cancer. …”
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175por Lim, Chae-Seok, Nam, Hye Jin, Lee, Jaehyun, Kim, Dongha, Choi, Ja Eun, Kang, SukJae Joshua, Kim, Somi, Kim, Hyopil, Kwak, Chuljung, Shim, Kyu-Won, Kim, Siyong, Ko, Hyoung-Gon, Lee, Ro Un, Jang, Eun-Hae, Yoo, Juyoun, Shim, Jaehoon, Islam, Md Ariful, Lee, Yong-Seok, Lee, Jae-Hyung, Baek, Sung Hee, Kaang, Bong-Kiun“…Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in learning and memory is unknown. …”
Publicado 2017
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176“…The lysine-specific demethylase 1 (LSD1) is overexpressed in several cancers including rhabdomyosarcoma (RMS). …”
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177por Battaglia, Sebastiano, Karasik, Ellen, Gillard, Bryan, Williams, Jennifer, Winchester, Trisha, Moser, Michael T., Smiraglia, Dominic J, Foster, Barbara A.“…BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. …”
Publicado 2017
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178por Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K., Rao, S.“…LSD1 couples to PKC-θ on the mesenchymal gene epigenetic template promotes LSD1-mediated gene induction. …”
Publicado 2018
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179“…We use forward simulations to demonstrate that LSD can identify branches targeted by positive selection with remarkable sensitivity and specificity. …”
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180por Alagarswamy, Kokiladevi, Shinohara, Ken-Ichi, Takayanagi, Shihori, Fukuyo, Masaki, Okabe, Atsushi, Rahmutulla, Bahityar, Yoda, Natsumi, Qin, Rui, Shiga, Naoki, Sugiura, Masahiro, Sato, Hiroaki, Kita, Kazuko, Suzuki, Takayoshi, Nemoto, Tetsuhiro, Kaneda, Atsushi“…NCD38 inhibits lysine-specific demethylase-1 (LSD1), a histone demethylase targeting H3K4me1 and H3K4me2, but not H3K4me3. …”
Publicado 2018
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