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Mostrando 161 - 180 Resultados de 1,917 Para Buscar '"LSD"', tiempo de consulta: 0.20s Limitar resultados
  1. 161
    “…However, the effect of LSD1 on lipid metabolism remains unclear. In the present study, we used a LC-MS/MS-based lipidomics approach to investigate the impact of LSD1 on cancer cell lipid metabolism using ZY0511, a specific LSD1 inhibitor developed by our group as a specific probe. …”
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    Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
  2. 162
    “…Compound L8 as a selective and reversible LSD1 inhibitor could inhibit LSD1 with the IC(50) value of 60 nM. …”
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    Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells
  3. 163
    “…Herein we describe the design, synthesis, and biological evaluation of a novel series of tranylcypromine-based LSD1 inhibitors via conformational restriction using spiro ring systems. …”
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    Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
  4. 164
    “…In addition, metabolite 1 showed significant inhibitory effect on lysine-specific demethylase 1 (LSD1) (IC(50) 1.99 μM). Therefore, the biotransformation of dihydrocapsaicin by intestinal fungi afforded various derivatives, which were important resources for developing LSD1 inhibitors and potential application in cancer treatment.…”
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    Biotransformation of dihydrocapsaicin by human intestinal fungi and the inhibitory effects of metabolites against LSD1
  5. 165
    “…Using skeletal muscle-specific LSD1-knockout mice and in vitro approaches, we found that LSD1 loss exacerbated glucocorticoid-induced atrophy in the fast fiber-dominant muscles, with reduced nuclear retention of Foxk1, an anti-autophagic transcription factor. …”
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    LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle
  6. 166
    “…From SY to F6 follicles, 190 phosphorylation sites of 149 proteins changed significantly, among which the phosphorylation level of lysine demethylase 1 A (LSD1) at the conserved 54(th) serine (LSD1Ser54p) was significantly upregulated in F6 follicles compared to SY follicles (p < 0.05); however, the expression of chicken LSD1 were not significantly different on both mRNA and protein levels. …”
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    Phosphoproteomic analysis on ovarian follicles reveals the involvement of LSD1 phosphorylation in Chicken follicle selection
  7. 167
    “…Lysine‐specific histone demethylase 1 (LSD1) is an attractive target for malignancies therapy. …”
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    Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B
  8. 168
    “…In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two S. pombe proteins, which we name Swm1 and Swm2 (after SWIRM1 and SWIRM2), associate together in a complex. …”
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    Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1
  9. 169
    por Halberstadt, Adam L., Geyer, Mark A.
    Publicado 2009
    “…RATIONALE: Compounds that activate the 5-HT(2A) receptor, such as lysergic acid diethylamide (LSD), act as hallucinogens in humans. One notable exception is the LSD congener lisuride, which does not have hallucinogenic effects in humans even though it is a potent 5-HT(2A) agonist. …”
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    LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor
  10. 170
    “…Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a flavin-dependent amine oxidase which specifically demethylates mono- or dimethylated H3K4 and H3K9 via a redox process. …”
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    Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
  11. 171
    “…Lsd1 does not directly target the dpp locus in escort cells. …”
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    Lsd1 Restricts the Number of Germline Stem Cells by Regulating Multiple Targets in Escort Cells
  12. 172
    “…Consequently, most Lsd1-null oocytes fail to complete meiosis I and undergo apoptosis. …”
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    LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice
  13. 173
    “…In this study, we found that forced the expression of miR‐708 in breast cancer cell lines decreased cell proliferation and invasion, whereas inhibition of miR‐708 increased cell growth and invasion. miR‐708 could directly target the LSD1 3′UTR to downregulate the expression. Further studies suggested that inhibition of LSD1 could phenocopied function of the miR‐708 overexpression in MDA‐MB‐231 cells .Overexpression of LSD1 could counteract the effects of miR‐708 on the proliferation and invasion. …”
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    miR‐708/LSD1 axis regulates the proliferation and invasion of breast cancer cells
  14. 174
    “…PURPOSE: This study aims to identify downstream target genes regulated by lysine-specific demethylase 1 (LSD1) in colon cancer cells and investigate the molecular mechanisms of LSD1 influencing invasion and metastasis of colon cancer. …”
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    Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells
  15. 175
    “…Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in learning and memory is unknown. …”
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    PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory
  16. 176
    “…The lysine-specific demethylase 1 (LSD1) is overexpressed in several cancers including rhabdomyosarcoma (RMS). …”
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    Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
  17. 177
    “…BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. …”
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    LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
  18. 178
    “…LSD1 couples to PKC-θ on the mesenchymal gene epigenetic template promotes LSD1-mediated gene induction. …”
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    LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
  19. 179
    por Librado, Pablo, Orlando, Ludovic
    Publicado 2018
    “…We use forward simulations to demonstrate that LSD can identify branches targeted by positive selection with remarkable sensitivity and specificity. …”
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    Detecting Signatures of Positive Selection along Defined Branches of a Population Tree Using LSD
  20. 180
    “…NCD38 inhibits lysine-specific demethylase-1 (LSD1), a histone demethylase targeting H3K4me1 and H3K4me2, but not H3K4me3. …”
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    Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide
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