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Abuso de drogas
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Alucinógenos y experiencias religiosas
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Dietilamida del ácido lisérgico (lsd)
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LSD (Droga)
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2por Malagraba, Gianluca, Yarmohammadi, Mahdieh, Javed, Aadil, Barceló, Carles, Rubio-Tomás, Teresa“…Lysine-specific demethylase 1 (LSD1) and its homolog, lysine-specific demethylase 2 (LSD2), are overexpressed in a variety of human cancer types and, thus, regulate tumour progression. …”
Publicado 2022
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5por Liechti, Matthias E“…All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD) in healthy subjects or patients in the last 25 years are reviewed herein. …”
Publicado 2017
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9por Liu, Xiaochuan, Li, Zhonghai, Jiang, Zhiqiang, Zhao, Yi, Peng, Jinying, Jin, Jinpu, Guo, Hongwei, Luo, Jingchu“…By broad literature survey, we have developed a leaf senescence database (LSD, http://www.eplantsenescence.org/) that contains a total of 1145 senescence associated genes (SAGs) from 21 species. …”
Publicado 2011
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10“…An enzyme called LSD1 that controls the development of blood cells by manipulating gene expression in progenitor cells could be a therapeutic target for leukemia.…”
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12Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugatespor Itoh, Yukihiro, Ogasawara, Daisuke, Ota, Yosuke, Mizukami, Tamio, Suzuki, Takayoshi“…Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inactivators. …”
Publicado 2014
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13por Marayati, Bahjat F., Tucker, James F., De La Cerda, David A., Hou, Tien-Chi, Chen, Rong, Sugiyama, Tomoyasu, Pease, James B., Zhang, Ke“…The evolutionarily conserved lysine-specific demethylases, Lsd1 and Lsd2, remove mono- and dimethylation on histone H3, serving complex roles in gene expression. …”
Publicado 2020
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14por Niwa, Hideaki, Watanabe, Chiduru, Sato, Shin, Harada, Toshiyuki, Watanabe, Hisami, Tabusa, Ryo, Fukasawa, Shunsuke, Shiobara, Ayane, Hashimoto, Tomoko, Ohno, Osamu, Nakamura, Kana, Tsuganezawa, Keiko, Tanaka, Akiko, Shirouzu, Mikako, Honma, Teruki, Matsuno, Kenji, Umehara, Takashi“…Here we synthesized 65 cis- and trans-PCPA derivatives and evaluated their inhibitory activity against LSD1 and LSD2. One of the derivatives, 7c (cis-4-Br-2,5-F(2)-PCPA; S1024), inhibited LSD1 and LSD2 with K(i) values of 0.094 μM and 8.4 μM, respectively, and increased the level of dimethylated histone H3 at K4 in CCRF-CEM cells. …”
Publicado 2022
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19“…LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. …”
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20“…Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. …”
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