“… : Skipping breakfast and late-night-eating have been associated with risk factors for type 2 diabetes (T2D). …”
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“…After a 2-month diagnostic evaluation for premenstrual dysphoric disorder (PMDD per DSM-5 criteria) in a university clinical research setting, 44 participants enrolled in baseline studies were randomized in the luteal phase at home to (A) a phase-advance intervention (PAI): 1 night of late-night wake therapy (LWT: sleep 9 pm–1 am) followed by 7 days of the morning (AM) bright white light (BWL), or (B) a phase-delay intervention (PDI): 1 night of early-night wake therapy (EWT: sleep 3–7 am) plus 7 days of the evening (PM) BWL. …”
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“…Multivariate analysis revealed that the following factors have a direct impact on survival: age of diagnosis ≥51 years (OR 4,493; 95% CI 2,056–9,818, p<0,001), bronchopulmonary neuroendocrine tumor (NET) (OR 0,281; 95% CI 0,119–0,665, p=0,004), the presence of distant metastases (OR 2,489; 95% CI 1,141–5,427, p=0,022), late-night salivary cortisol (LNSC) ≥122,2 nmol/L (OR 2,493; 95% CI 1,014–6,128, p=0,047).CONCLUSION: The prognosis of patients with EAS is influenced by the age of diagnosis, NET localization, distant metastases and level of LNSC. …”
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“…All eight patients had abnormal low-dose dexamethasone suppression test (DST) [post DST serum cortisol 2.2-19.1 mcg/dL (RI<1.8)] and increased late-night salivary cortisol [8.2-71.0 nmol/L (RI<3.2)]. …”
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“…Hypercortisolism was confirmed biochemically with elevated late night salivary cortisol test, urinary free cortisol and 1mg dexamethasone suppression test. …”
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“…Upon re-testing in January 2018, persistent hypercortisolemia was confirmed with 24-hr UFCs x 2 and late-night salivary cortisols x 2 that were > 2 ULN, and nonsuppressed AM cortisol after a 1 mg overnight dexamethasone suppression test. …”
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“…A biochemical investigation showed an assessment of late-night salivary cortisol - 23 nmol/l (n <9), 24h urinary free cortisol (UFC)- 1206 nmol/24h (n-60–413). …”
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“…The following meal timing measures were defined: 1) The time of the last and first calorie intake either from food or drink, 2) Eating window: The time elapsed between the first and last food intake, 3) Nighttime fasting duration: The time between last and first food intake, 4) Calorie midpoint time: The time when half of the calories for the day were consumed, 5) Late night eating: Consumption of ≥33% of total daily energy between 5:00 pm and midnight, and 6) Eating frequency: Frequency of food or beverage consumption >0 kcal which were >15 minutes apart. …”
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“…Laboratory results showed late night salivary cortisol levels of 4.60 ug/dl and 4.80 ug/dl, values which may be high or even normal due to ineffective steroidogenesis on PBMAH. …”
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“…Hemoglobin A1c 9.6 %, random cortisol 46.2mcg/dL, ACTH 72.4 pg/ml (7.2-63.3), late-night salivary cortisol sample was inadequate to assess, 24-hour urine cortisol 1802 ug/24 hr (6-42). …”
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“…Endogenous (body-produced) Cushing’s is diagnosed using Late Night Salivary Cortisol(LNSC), Dexamethasone Suppression Test(DST), or 24-hr Urinary-Free Cortisol(UFC) and after ruling out exogenous glucocorticoid administration. …”
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“…RESULTS: We found that Merriam’s kangaroo rats are only active during the nighttime phases of the diel cycle and are particularly active during later light phases of the night (i.e., late night, morning twilight, and dawn). We found no reduction in activity or foraging associated with moonlight, indicating that kangaroo rats are actually more lunarphilic than lunarphobic. …”
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“…CH patients without prior pituitary surgery on average had a greater absolute number of negative late-night salivary cortisol results than CD patients (p=0.006). …”
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“…However, her 24-hour urinary free cortisol (UFC) and two late night salivary cortisols were elevated with a suppressed ACTH (UFC 85.9 with normal range 4-50 mcg/24hr, salivary cortisols 0.24 and 0.18 with normal range 0.01-0.09 mcg/dl). …”
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“…Case 1: 22-year-old (yo): Basal (203) and post oDST (83) ACTH(I) were elevated; however, AM serum cortisol, late-night salivary cortisol (LNSC), and post 1 mg overnight dexamethasone suppression test (oDST) cortisol were all normal. …”
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“…Secondary endpoints include changes from baseline to all postbaseline visits in R-W phase for mUFC, late-night salivary cortisol, CS cardiovascular biomarkers (fasting glucose, fasting insulin, hemoglobin A1c, homeostatic model assessment-insulin resistance, total and LDL cholesterol, high-sensitivity C-reactive protein), CS clinical signs and symptoms (acne, hirsutism [women only], and peripheral edema scores), and patient-reported outcomes of QoL (Cushing QoL questionnaire score) and depression (Beck Depression Inventory II). …”
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“…In our case, first-line screening tests could differentiate between PCS and CD hence she did not require late-night salivary cortisol testing or corticotropic-releasing hormone testing. …”
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“…Factitious disorder or sample contamination can be yet another challenge in the differential diagnosis of Cushing’s work up. (1) Raff H Measurement of Late-Night, Salivary Cortisol and Cortisone by LC-MS/MS to Assess Preanalytical Sample Contamination with Topical Hydrocortisone. …”
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“…She had multiple low dose dexamethasone suppression tests with AM cortisol levels in 17-21 ug/dL range (<1.8 ug/dL). She had late night salivary cortisols of 0.885ug/dL and 1.935ug/dL (0.022-0.254 ug/dl in PM). …”
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“…Laboratories revealed a glycated hemoglobin of 6.1%, late-night salivary cortisol of <0.03 mcg/dL, 24-hour urine free cortisol of 22.5 mcg/24hr, morning cortisol of 0.01 ug/mL, ACTH 23.5pg/mL, and dehydroepiandrosterone sulfate (DHEA-S) 35 mcg/dL. …”
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