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4por Montalbano, Marzia, Levi Sandri, Giovanni Battista, Visco Comandini, Ubaldo, Lionetti, Raffaella, Vincenzi, Laura, Berardi, Giammauro, Guglielmo, Nicola, Pellicelli, Adriano, Ettorre, Giuseppe Maria, D’Offizi, Gianpiero“…We report the positive experience of a single Transplant Center in Rome, part of the National Institute for Infectious Diseases Lazzaro Spallanzani, one of the major national centers involved in the COVID-19 emergency.…”
Publicado 2020
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5“…They are then evaluated by the Clinical Trial Office of the Competent Authority (AIFA) and by the EC of the Lazzaro Spallanzani National Institute for Infectious Diseases. …”
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6por D’Abramo, Alessandra, Gebremeskel Tekle, Saba, Iannetta, Marco, Scorzolini, Laura, Oliva, Alessandra, Paglia, Maria Grazia, Corpolongo, Angela, Nicastri, Emanuele“…CASE PRESENTATION: A 37-year old Caucasian man returning home from Angola was admitted for ovale malaria to the National Institute for Infectious Diseases Lazzaro Spallanzani in Rome, Italy. Two days after initiation of oral chloroquine treatment, an acute respiratory distress syndrome was diagnosed through chest X-ray and chest CT scan with intravenous contrast. …”
Publicado 2018
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7por D’Abramo, Alessandra, Lepore, Luciana, Iannetta, Marco, Gebremeskel Tekle, Saba, Corpolongo, Angela, Scorzolini, Laura, Bevilacqua, Nazario, Mariano, Andrea, Giancola, Maria Letizia, Vulcano, Antonella, Maritti, Micaela, Agresta, Alessandro, Antonini, Mario, D’Alessandro, Umberto, Nicastri, Emanuele“…OBJECTIVES: This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the “Lazzaro Spallanzani” National Institute for Infectious Diseases, Rome, Italy. …”
Publicado 2019
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8por Biava, Mirella, Caglioti, Claudia, Bordi, Licia, Castilletti, Concetta, Colavita, Francesca, Quartu, Serena, Nicastri, Emanuele, Lauria, Francesco Nicola, Petrosillo, Nicola, Lanini, Simone, Hoenen, Thomas, Kobinger, Gary, Zumla, Alimuddin, Di Caro, Antonino, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Lalle, Eleonora“…We have longitudinally explored the persistence of EBOV-specific negative sense genomic RNA (neg-RNA) and the presence of positive sense RNA (pos-RNA), including both replication intermediate (antigenomic-RNA) and messenger RNA (mRNA) molecules, in the upper and lower respiratory tract, as compared to plasma, in a HCW infected with EBOV in Sierra Leone, who was hospitalized in the high isolation facility of the National Institute for Infectious Diseases “Lazzaro Spallanzani” (INMI), Rome, Italy. We observed persistence of pos-RNA and neg-RNAs in longitudinally collected specimens of the lower respiratory tract, even after viral clearance from plasma, suggesting possible local replication. …”
Publicado 2017
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9por Sberna, Giuseppe, Amendola, Alessandra, Valli, Maria Beatrice, Carletti, Fabrizio, Capobianchi, Maria Rosaria, Bordi, Licia, Lalle, Eleonora“…From 1 February to 12 April 2020, 17,164 nasopharyngeal swabs were tested by real time PCR for the presence of SARS-CoV-2 at the Laboratory of Virology of National Institute for Infectious Diseases “Lazzaro Spallanzani” (INMI) in Rome. In the same period, coincident with the winter peak of influenza and other respiratory illnesses, 847 samples were analyzed by multiplex PCR assay for the presence of common respiratory pathogens. …”
Publicado 2020
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10“…We identified all the cases of CS-MRSA infections in HIV-infected patients admitted to the National Institute for Infectious Diseases (INMI) "Lazzaro Spallanzani" in the 4-year study period. A conditional logistic regression model was used to identify risk factors for CS-MRSA infection. …”
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11por Lanini, Simone, Garbuglia, Anna Rosa, Lapa, Daniele, Puro, Vincenzo, Navarra, Assunta, Pergola, Catia, Ippolito, Giuseppe, Capobianchi, Maria Rosaria“…SETTING: The HIV prevention unit at the National Institute for Infectious Diseases Lazzaro Spallanzani, serving as a referral centre for HIV infection in Lazio, an Italian Region with about 5.6 million inhabitants. …”
Publicado 2015
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12por Agrati, C, Castilletti, C, Casetti, R, Sacchi, A, Falasca, L, Turchi, F, Tumino, N, Bordoni, V, Cimini, E, Viola, D, Lalle, E, Bordi, L, Lanini, S, Martini, F, Nicastri, E, Petrosillo, N, Puro, V, Piacentini, M, Di Caro, A, Kobinger, G P, Zumla, A, Ippolito, G, Capobianchi, M R“…Two EVD patients admitted to the Italian National Institute for Infectious Diseases, Lazzaro Spallanzani, were sampled sequentially from soon after symptom onset until recovery and analyzed by flow cytometry and ELISpot assay. …”
Publicado 2016
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13por D’Abramo, Alessandra, Vita, Serena, Maffongelli, Gaetano, Beccacece, Alessia, Agrati, Chiara, Cimini, Eleonora, Colavita, Francesca, Giancola, Maria Letizia, Cavasio, Alessandro, Nicastri, Emanuele“…We retrospectively enrolled a total number of 21 B-cell depleted consecutive hospitalized patients with COVID-19 at the Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy, from November 2020 to December 2021. …”
Publicado 2022
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14por Mastrorosa, Ilaria, Cozzi-Lepri, Alessandro, Colavita, Francesca, Lalle, Eleonora, Mazzotta, Valentina, Cimaglia, Claudia, Paulicelli, Jessica, Matusali, Giulia, Fabeni, Lavinia, Carletti, Fabrizio, Rosati, Silvia, Vita, Serena, Giannico, Giuseppina, Piselli, Pierluca, Biliotti, Elisa, Moghazi, Samir Al, Mosti, Silvia, Girardi, Enrico, Nicastri, Emanuele, Garbuglia, Anna Rosa, Maggi, Fabrizio, Vaia, Francesco, Antinori, Andrea“…STUDY DESIGN: Observational single-center comparative analysis of patients with early mild-to-moderate COVID-19, enrolled within the early treatment access program of Lazzaro Spallanzani Institute (March 2021-March 2022). NP-VL before drug administration was estimated through RT-PCR, based on cycle threshold values (CTs); VOCs were identified by Sanger sequencing. …”
Publicado 2022
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15por Mastrorosa, Ilaria, Gagliardini, Roberta, Segala, Francesco Vladimiro, Mondi, Annalisa, Lorenzini, Patrizia, Cerva, Carlotta, Taddei, Eleonora, Bai, Francesca, Vergori, Alessandra, Marcantonio, Negri, Pinnetti, Carmela, Cicalini, Stefania, Murri, Rita, Mazzotta, Valentina, Camici, Marta, Mosti, Silvia, Bini, Teresa, Maffongelli, Gaetano, Beccacece, Alessia, Milozzi, Eugenia, Iannetta, Marco, Lamonica, Silvia, Fusto, Marisa, Plazzi, Maria Maddalena, Ottou, Sandrine, Lichtner, Miriam, Fantoni, Massimo, Andreoni, Massimo, Sarmati, Loredana, Cauda, Roberto, Girardi, Enrico, Nicastri, Emanuele, D'Arminio Monforte, Antonella, Palmieri, Fabrizio, Cingolani, Antonella, Vaia, Francesco, Antinori, Andrea“…FUNDING: This study was supported by INMI “Lazzaro Spallanzani” Ricerca Corrente Linea 1 on emerging and reemerging infections, funded by 10.13039/501100003196Italian Ministry of Health.…”
Publicado 2023
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16por Agrati, Chiara, Cossarizza, Andrea, Mazzotta, Valentina, Grassi, Germana, Casetti, Rita, De Biasi, Sara, Pinnetti, Carmela, Gili, Simona, Mondi, Annalisa, Cristofanelli, Flavia, Lo Tartaro, Domenico, Notari, Stefania, Maffongelli, Gaetano, Gagliardini, Roberta, Gibellini, Lara, Aguglia, Camilla, Lanini, Simone, D'Abramo, Alessandra, Matusali, Giulia, Fontana, Carla, Nicastri, Emanuele, Maggi, Fabrizio, Girardi, Enrico, Vaia, Francesco, Antinori, Andrea“…METHODS: 17 patients with laboratory-confirmed monkeypox admitted at the Lazzaro Spallanzani National Institute for Infectious Diseases (Rome, Italy), from May 19, to July 7, 2022, were tested for differentiation and activation profile of CD4 and CD8 T (expression of CD38, PD-1, and CD57 assessed by flow cytometry), frequency of pox-specific T cells (by standard interferon-γ ELISpot), and release of interleukin (IL)-1β, IL-6, IL-8, and tumour necrosis factor (TNF) in plasma (by ELISA). …”
Publicado 2023
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17por Aricò, Eleonora, Castiello, Luciano, Bracci, Laura, Urbani, Francesca, Lombardo, Flavia, Bacigalupo, Ilaria, Ancidoni, Antonio, Vanacore, Nicola, Falcione, Alessandro, Reggiani, Chiara, Dutti, Giovanni Marco, Maglie, Maria Grazia, Papa, Ombretta, Bartoletti, Pier Luigi, Ozzella, Giuseppina, Bevilacqua, Nazario, Nicastri, Emanuele, Belardelli, Filippo, Sconocchia, Giuseppe“…A group of physicians belonging to the Special Unit for Regional Continued Care (USCAR), specifically trained for the study and under the supervision of the National Institute for Infectious Diseases “Lazzaro Spallanzani”, will be responsible for the screening, enrolment, treatment and clinical monitoring of patients, thus acting as a bridge between clinical centers and territorial health management. ≥ 65 years of age at time of enrolment; Laboratory-confirmed SARS-CoV-2 infection as determined by PCR, in any specimen < 72 hours prior to randomization; Subject (or legally authorized representative) provides written informed consent prior to initiation of any study procedures; Understands and agrees to comply with planned study procedures; Agrees to the collection of nasopharyngeal swabs and venous blood samples per protocol; Being symptomatic for less than 7 days before starting therapy; NEWS2 score ≤2. …”
Publicado 2021
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