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761“…METHODS: All newly referred subfertile women admitted to the Reproductive Medicine Clinic of Leiden University Medical Centre between 1 April 1997 and 31 December 1999, were eligible for the study. …”
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762por Triques, Karine, Piednoir, Elodie, Dalmais, Marion, Schmidt, Julien, Le Signor, Christine, Sharkey, Mark, Caboche, Michel, Sturbois, Bénédicte, Bendahmane, Abdelhafid“…In human, we report the diagnosis of the G1691A mutation in Leiden factor-V gene associated with venous thrombosis and the fingerprinting of HIV-1 quasispecies in patients subjected to antiretroviral treatments. …”
Publicado 2008
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763por Evagelidou, Eleni N., Giapros, Vasileios I., Challa, Anna S., Cholevas, Vasileios K., Vartholomatos, Georgios A., Siomou, Ekaterini C., Kolaitis, Nikolaos I., Bairaktari, Eleni T., Andronikou, Styliani K.“…RESEARCH DESIGN AND METHODS: At 6–7 years of age, the comparison of various factors was made between 31 LGA and 34 appropriate-for-gestational-age (AGA) children: fibrinogen, antithrombin III, protein C and S, fasting insulin, glucose, homeostasis assessment model of insulin resistance (HOMA-IR) index, adiponectin, leptin, visfatin, IGF-1, IGF-binding protein (IGFBP)-1, IGFBP-3, lipids, and the genetic factors V Leiden G1691A mutation, prothrombin 20210A/G polymorphism, and mutation in the enzyme 5,10-methylenetetrahydrofolate-reductase gene (MTHFR-C677T). …”
Publicado 2010
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764por Konecny, Filip“…Newly increased interest in an inherited thrombophilic states has been provoked by the discovery of several common inherited abnormalities, i.e. the prothrombin (PT) gene G20210A, Factor V Leiden (FVL) mutation (Arg506Gln), hyperhomocystenemia and homocysteiuria, Wein-Penzing defect, Sticky Platelet Syndrome (SPS), Quebec platelet disorder (QPD) and Sickle Cell Disease (SCD). …”
Publicado 2009
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765“…RESULTS: For these five candidate genes studied, the prothrombin OR is 1,57 (1,23-2,89), the factor V Leiden OR is 1,43 (0,67-6,24), the mean OR of angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism is 1,11 (1,02-1,25), the summary OR for the C677T variant of 5,10-methylenetetrahydrofolate reductase (MTHFR) is 1,23 (0,61-1,47) and the pooled OR for the apolipoprotein E (APOE) gene is 0,95 (0,77-1,14) . …”
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766por Rius-Ottenheim, Nathaly, Kromhout, Daan, de Craen, Anton J. M., Geleijnse, Johanna M., van der Mast, Roos C., Zitman, Frans G., Westendorp, Rudi G., Slagboom, P. Eline, Giltay, Erik J.“…Parental age of death was assessed using structured questionnaires in two different population-based samples: the Leiden Longevity Study (n = 1,252, 52.2% female, mean age 66 years, SD = 4) and the Alpha Omega Trial (n = 769, 22.8% female, mean age 69 years, SD = 6). …”
Publicado 2011
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767por Cynis, Holger, Hoffmann, Torsten, Friedrich, Daniel, Kehlen, Astrid, Gans, Kathrin, Kleinschmidt, Martin, Rahfeld, Jens-Ulrich, Wolf, Raik, Wermann, Michael, Stephan, Anett, Haegele, Monique, Sedlmeier, Reinhard, Graubner, Sigrid, Jagla, Wolfgang, Müller, Anke, Eichentopf, Rico, Heiser, Ulrich, Seifert, Franziska, Quax, Paul H A, de Vries, Margreet R, Hesse, Isabel, Trautwein, Daniela, Wollert, Ulrich, Berg, Sabine, Freyse, Ernst-Joachim, Schilling, Stephan, Demuth, Hans-Ulrich“…The pharmacologic efficacy of QC/isoQC-inhibition was assessed in accelerated atherosclerosis in ApoE3*Leiden mice, showing attenuated atherosclerotic pathology following chronic oral treatment. …”
Publicado 2011
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768“…We performed a study to evaluate the role of three single nucleotide polymorphisms (SNPs), factor V Leiden G1691A (FVL), prothrombin gene mutation G20210A (PRT or FII-G20210A) and methylenotetrahydrofolate reductase variant C677T (MTHFRC677T), as risk factors for G6PD in Saudi populations. …”
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769“…Various prothrombotic risk factors have been investigated in pediatric stroke including elevated homocysteine and lipoprotein (a), antithrombin, protein C and protein S deficiency, Factor V Leiden, Factor II G20210A and plasminogen activator inhibitor-1 4G/5G polymorphism. …”
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770“…Genotyping for factor V Leiden, prothrombin gene (nucleotide G20210A), and MTHFR (C677T) mutation was performed by PCR technique. …”
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771por Hendriks, Sanne M, Licht, Carmilla MM, Spijker, Jan, Beekman, Aartjan TF, Hardeveld, Florian, de Graaf, Ron, Penninx, Brenda WJH“…Cognitive profiles were measured using the Leiden Index of Depression Sensitivity, the Anxiety Sensitivity Index, and the Penn State Worry Questionnaire. …”
Publicado 2014
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772por Kumari, Babita, Srivastava, Swati, Chatterjee, Tathagat, Vardhan, Rig, Tyagi, Tarun, Gupta, Neha, Sahu, Anita, Chandra, Khem, Ashraf, Mohammad Zahid“…A PCR-RFLP based analysis was performed for nine mutations in the following genes associated with VTE: favtor V Leiden (FVL), prothrombin, tissue factor pathway inhibitor (TFPI), fibrinogen-beta, plasminogen activator inhibitor 1 (PAI-1), and methylene tetrahydrofolatereductase (MTHFR). …”
Publicado 2014
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773“…In 6 patients with familial thrombophilia (5 Factor V (FV) Leiden heterozygotes, 1 with resistance to activated protein C (RAPC)), we prospectively assessed whether continuous longterm (4–16 years) anticoagulation would prevent progression of idiopathic osteonecrosis (ON), ameliorate pain, and facilitate functional recovery. …”
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774por Kumar, Narender, Ahluwalia, Jasmina, Das, Reena, Rohilla, Meenakshi, Bose, Sunil, Kishan, Hari, Varma, Neelam“…A total of 40 patients had been investigated for inherited thrombophilia workup (protein C, protein S [PS], antithrombin III, and factor V Leiden [FVL] mutation) over a period of 10 years (2005 to 2014). …”
Publicado 2015
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775por Bagheri Lankarani, Kamran, Homayon, Katayon, Motevalli, Dorna, Heidari, Seyed Taghi, Alavian, Seyed Moayed, Malek-Hosseini, Seyed Ali“…The patients were evaluated by history, physical examination, and laboratory tests, including factor V Leiden, prothrombin gene mutation, Janus Kinase 2 (JAK2) mutation, and serum levels of protein C, protein S, antithrombin III, homocysteine, factor VIII, and anticardiolipin antibodies. …”
Publicado 2015
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776por Arévalo Simental, Diana E., Roig Melo-Granados, Enrique A., Cortés Quezada, Saúl, Páez Escamilla, Manuel A., Soria Orozco, Carmen L., Jacinto Buenrostro, Jorge E.“…Laboratory testing included complete blood cell count, homocysteine, protein c, protein s, activated protein s, methyltetrahydrofolate and homocysteine activator genes, factor leiden V gene, antithrombin III, and activated protein c resistance. …”
Publicado 2016
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777por Sun, Guoping, Jia, Yicong, Meng, Jingye, Ou, Minglin, Zhu, Peng, Cong, Shan, Luo, Yadan, Sui, Weiguo, Dai, Yong“…Well-known factors that result in predisposition to congenital disorders associated with thrombophilia include antithrombin deficiency, protein C and S deficiency, Factor V Leiden mutation, abnormal prothrombin and antiphospholipid syndrome. …”
Publicado 2017
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778por Bartelt, Alexander, John, Clara, Schaltenberg, Nicola, Berbée, Jimmy F. P., Worthmann, Anna, Cherradi, M. Lisa, Schlein, Christian, Piepenburg, Julia, Boon, Mariëtte R., Rinninger, Franz, Heine, Markus, Toedter, Klaus, Niemeier, Andreas, Nilsson, Stefan K., Fischer, Markus, Wijers, Sander L., van Marken Lichtenbelt, Wouter, Scheja, Ludger, Rensen, Patrick C. N., Heeren, Joerg“…Here, we report a reduction in atherosclerosis in response to pharmacological stimulation of thermogenesis linked to increased HDL levels in APOE*3-Leiden.CETP mice. Both cold-induced and pharmacological thermogenic activation enhances HDL remodelling, which is associated with specific lipidomic changes in mouse and human HDL. …”
Publicado 2017
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779por Terveer, Elisabeth M., Nijhuis, Roel H. T., Crobach, Monique J. T., Knetsch, Cornelis W., Veldkamp, Karin E., Gooskens, Jairo, Kuijper, Ed J., Claas, Eric C. J.“…From November 2014 until July 2015, fecal samples of patients attending the Leiden University Medical Center were collected and screened for presence of mcr using real-time PCR. …”
Publicado 2017
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780por Dusse, Luci Maria SantAna, Silva, Marcos Vinícius Ferreira, Freitas, Letícia Gonçalves, Marcolino, Milena Soriano, Carvalho, Maria das Graças“…The most important genetic risk factors are natural anticoagulant deficiencies (antithrombin, protein C and protein S), factor V Leiden, prothrombin and fibrinogen gene mutations and non-O blood group individuals. …”
Publicado 2017
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