“…Genetic causes include antithrombin III, protein C, protein S, factor V Leiden, prothrombin 20210A allele, and MTHFR mutations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The 2016 European Vasculitis Society (EUVAS) meeting, held in Leiden, the Netherlands, was centered around phenotypic subtyping in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We evaluated the safety for newborns born with FCS in the Leiden University Medical Center (LUMC), where FCS was implemented in June 2014 for singleton pregnancies with a gestational age (GA) ≥38 weeks and without increased risks for respiratory morbidity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Anti-β2-glycoprotein I and lupus anticoagulant were positive in 4.8% and 11.9% of patients, respectively. Factor V Leiden mutation analysis was positive in 6.1% of patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Healthy volunteers (age 18–35) were recruited at the Leiden University Medical Center. Retinal images were acquired with the handheld oximeter and the Oxymap T1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although the Factor V Leiden (FVL) gene variant is the most prevalent genetic risk factor for venous thrombosis, only 10% of FVL carriers will experience such an event in their lifetime. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: For this study, we selected 9 pairs of patients with Huntington disease matched for mutant CAG repeat size and sex, but with a difference of at least 10 years in age at onset, using the Leiden Huntington disease database. From skin biopsies, we isolated fibroblasts in which we (1) quantified the ATP concentration before and after a hydrogen-peroxide challenge and (2) measured mitochondrial respiration and glycolysis in real time, using the Seahorse XF Extracellular Flux Analyzer XF24. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additional preoperative laboratory review revealed findings for activated protein C resistance, low protein S activity, antinuclear antibody (>1:160), anti-cardiolipin IgM antibody (16.6), and thrombocytosis, Janus kinase and factor V Leiden mutations. At the intensive care unit, heparin was continually infused until postoperative day 12 and was then switched to warfarin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mice carrying transgenes for human apolipoprotein E*3‐Leiden and cholesteryl ester transfer protein and fed a “Western” diet were studied on the genetic backgrounds of over 100 inbred mouse strains. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Only original human research in English language with full text availability through the Leiden university library was considered for this review. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We frequently sampled blood over 24 h in 19 middle‐aged offspring of long‐living families from the Leiden Longevity Study together with 18 of their partners as controls. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: In this prospective study, assisted women with RM or repeated implant failure (RIF) were subjected to Thromboincode analysis, in order to identify 12 genetic variants for Factor V Leiden, Factor V Hong Kong, Factor V Cambridge, FII, FXIII, FXII, and A1 carriers. …”
Enlace del recurso
Enlace del recurso

“…There were no significant differences between MINOCA and MICAD, respectively, in respect to the numbers of patients with congenital thrombophilia states including factor V Leiden (0 vs. 4%) and prothrombin gene mutation (8 vs. 4%), decreased antithrombin (8 vs. 0%), protein C (0 vs. 0%), and protein S (4 vs. 0%). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most frequent laboratory risk factors were increased levels of FVIII (n = 4), mild hyperhomocysteinemia (n = 3), and factor V Leiden mutation (n = 2). VTE developed within 3 months after antipsychotic drug initiation in three patients and within 6 months in three patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The present study demonstrates that extrapancreatic incidentaloma is a common finding in IARs for PDAC, but rarely requires additional treatment. CDKN2A-p16-Leiden mutation carriers were the only patient group found to harbor a substantial number of cancers, and detection resulted in benefit in several cases.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The clot-based assay has limitations because of interference with coagulation inhibitors resulting in spuriously increased protein C levels or underestimation because of elevated levels of factor VIII and Factor V-Leiden mutation. The chromogenic assay is not influenced by such interferences but only detects functional defects of protein C that involve the active site rendering it insensitive to rare mutations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found no association between RM and inherited thrombophilias in patients with PCOS: (1) Factor V Leiden (OR, 0.74; 95% CI, 0.38 – 1.45; p = 0.38); (2) C677T methylenetetrahydrofolate reductase polymorphism (MTHFR) (OR, 1.01; 95% CI, 0.64 – 1.59; p = 0.97); and (3) A1297C MTHFR polymorphism (OR, 1.08; 95% CI, 0.62 – 1.89; p = 0.77). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Naturalis Biodiversity Center (NBC) in Leiden is care keeper of large collections of marine organisms, which were sampled in the Northeast Atlantic during the CANCAP and Tyro Mauritania II expeditions (1976–1988). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: Cohort study including consecutive patients with ACTH-dependent Cushing's syndrome from Leiden and Berlin diagnosed between 2000 and 2016. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ICA images were submitted to Qangio XA (Medis, Leiden, The Netherlands) software for QCA analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso