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881por Miskinyte, Emilija, Bucius, Paulius, Erley, Jennifer, Zamani, Seyedeh Mahsa, Tanacli, Radu, Stehning, Christian, Schneeweis, Christopher, Lapinskas, Tomas, Pieske, Burkert, Falk, Volkmar, Gebker, Rolf, Pedrizzetti, Gianni, Solowjowa, Natalia, Kelle, Sebastian“…FT analysis was performed using Medis suite version 3.0 (Leiden, The Netherlands) software. Segment (Medviso) software was used for GCS assessment from tagged images. …”
Publicado 2019
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882por Khrait, Zakwan“…Her past medical history was significant for hypothyroidism and positive factor V Leiden. She underwent hystero contrast sonography, which revealed a normal uterine cavity with irregular fillings in the right corner. …”
Publicado 2019
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883por Klarin, Derek, Busenkell, Emma, Judy, Renae, Lynch, Julie, Levin, Michael, Haessler, Jeffery, Aragam, Krishna, Chaffin, Mark, Haas, Mary, Lindström, Sara, Assimes, Themistocles L., Huang, Jie, Lee, Kyung Min, Shao, Qing, Huffman, Jennifer E., Kabrhel, Christopher, Huang, Yunfeng, Sun, Yan V., Vujkovic, Marijana, Saleheen, Danish, Miller, Donald R., Reaven, Peter, DuVall, Scott, Boden, William E., Pyarajan, Saiju, Reiner, Alex P., Trégouët, David-Alexandre, Henke, Peter, Kooperberg, Charles, Gaziano, J. Michael, Concato, John, Rader, Daniel J., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W.F., Smith, Nicholas L., O’Donnell, Christopher J., Tsao, Philip S., Kathiresan, Sekar, Obi, Andrea, Damrauer, Scott M., Natarajan, Pradeep“…We developed a genome-wide polygenic risk score for VTE that identifies 5% of the population at equivalent incident VTE risk to carriers of the established F5 Leiden (p.R506Q) and prothrombin G20210A mutations. …”
Publicado 2019
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884por Zhang, Li, Zhang, Qianqian, Tang, Yaohua, Cong, Peikuan, Ye, Yuhua, Chen, Shiping, Zhang, Xinhua, Chen, Yan, Zhu, Baosheng, Cai, Wangwei, Chen, Shaoke, Cai, Ren, Guo, Xiaoling, Zhang, Chonglin, Zhou, Yuqiu, Zou, Jie, Liu, Yanhui, Chen, Biyan, Yan, Shanhuo, Chen, Yajun, Zhou, Yuehong, Ding, Hongmei, Li, Xiarong, Chen, Dianyu, Zhong, Jianmei, Shang, Xuan, Liu, Xuanzhu, Qi, Ming, Xu, Xiangmin“…The database was integrated into the Leiden Open Variation Database (LOVD), in which we included all reported variants focusing on a Chinese population by literature peer review‐curation and existing databases, such as HbVar and IthaGenes. …”
Publicado 2019
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885por Callegari, Alessia, Christmann, Martin, Albisetti, Manuela, Kretschmar, Oliver, Quandt, Daniel“…Two patients showed abnormal activated PC resistance ratio due to heterozygous factor V Leiden mutation and 1 heterozygous prothrombin G20210A mutation. …”
Publicado 2019
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886por Vrolijks, Ruben O., Notenboom‐Nas, Françoise J. M., de Boer, Deborah, Schouten, Tamara, Timmerman, Alice, Zijlstra, Aylene, Witte, Lambertus P. W., Knol‐de Vries, Grietje E., Blanker, Marco H.“…AIM: We aimed to explore the utility of the Multiple Array Probe Leiden (MAPLe) device to assess pelvic floor muscle activity in men with lower urinary tract symptoms (LUTS). …”
Publicado 2020
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887por Ree, Isabelle M.C., de Grauw, Anne M., Bekker, Vincent, de Haas, Masja, te Pas, Arjan B., Oepkes, Dick, Middeldorp, Annemieke (J.) M., Lopriore, Enrico“…MATERIALS AND METHODS: Retrospective cohort study of medical records of neonates with and without HDFN, with a gestational age at birth ≥30 weeks and ≤38 weeks, and admitted to the Leiden University Medical Center between January 2000 and December 2016. …”
Publicado 2019
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888por Cernera, Gustavo, Di Minno, Alessandro, Amato, Felice, Elce, Ausilia, Liguori, Renato, Bruzzese, Dario, Di Lullo, Antonella Miriam, Castaldo, Giuseppe, Zarrilli, Federica, Comegna, Marika“…Methods: We studied Factor V Leiden (FVL), FVR2, FII G20210A, Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, beta-fibrinogen -455 G>A, FXIII V34L, and HPA-1 L33P variants and PAI-1 4G/5G alleles in 343 male and female patients with deep vein thrombosis (DVT), 164 with pulmonary embolism (PE), 126 with superficial vein thrombosis (SVT), 118 with portal vein thrombosis (PVT), 75 with cerebral vein thrombosis (CVT) and 119 with retinal vein thrombosis (RVT), and compared them with the corresponding variants and alleles in 430 subjects from the general population. …”
Publicado 2020
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889“…CASE REPORT: A 12-year-old male with ESRD secondary to obstructive uropathy received a pre-emptive deceased donor kidney transplant that failed within a few days due to thrombosis secondary to factor V Leiden deficiency. Transplant nephrectomy was performed and several months later he was started on PD. …”
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890“…The most common thrombophilias tested were antiphospholipid syndrome (60.1%), factor V Leiden (59.7%), and prothrombin gene mutation (57.5%). …”
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891“…In addition, CLCN1 gene was sequenced by NGS (Next Generation Sequencing Method) and possible causes of inherited thrombophilia risk including MTHFR (A1298C), Factor V Leiden (G1691A), Factor II (G20210A), MTHFR (C677T), Factor V Cambridge (G1091C), plasminogen activator inhibitor 1 (PAI-1) 4G/5G, APOE, APOB, ITGB, ACE (ins/del), FVHR2 and FGB gene alterations were evaluated. …”
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892por Zutinic, Ana, Blauw, Gerard J, Pijl, Hanno, Ballieux, Bart E, Westendorp, Rudi G J, Roelfsema, Ferdinand, van Heemst, Diana“…CONTEXT: Familial longevity is associated with higher circulating levels of thyrotropin (TSH), in the absence of differences in circulating thyroid hormones, and a lower thyroid responsivity to TSH, as previously observed in the Leiden Longevity Study (LLS). Further mechanisms underlying these observations remain unknown. …”
Publicado 2020
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893por Andemeskel, Yonatan Mehari, Elsholz, Traudl, Gebreyohannes, Ghidey, Tesfamariam, Eyasu H.“…Patients were interviewed 24 hours after operation (POD 1) using the Leiden Perioperative care Patient Satisfaction questionnaire (LPPSq). …”
Publicado 2020
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894por Cauley, Edmund S., Pittman, Alan, Mummidivarpu, Swati, Karimiani, Ehsan G., Martinez, Samantha, Moroni, Isabella, Boostani, Reza, Podini, Daniele, Mora, Marina, Jamshidi, Yalda, Hoffman, Eric P., Manzini, M. Chiara“…Of the more than 300 likely pathogenic variants found in the Leiden Open Variant Database, the majority are truncating mutations leading to complete LAMA2 loss of function, but multiple copy number variants (CNVs) have also been reported with variable frequency. …”
Publicado 2020
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895por Verhagen, Iris E, van Casteren, Daphne S, de Vries Lentsch, Simone, Terwindt, Gisela M“…We identified 870 migraine patients treated at the Leiden Headache Center with headache e-diaries during the period of interest. …”
Publicado 2021
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896“…In the seventeenth and eighteenth centuries the Dutch universities, particularly the University of Leiden, were the leaders with respect to the clinical and practical student training.…”
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897por Mańkowska-Wierzbicka, Dorota, Kloska, Michał, Karwowska, Katarzyna, Kucharski, Marcin A., Wierzbicka, Adrianna, Iwanik, Katarzyna, Karmelita-Katulska, Katarzyna, Stelmach-Mardas, Marta, Dobrowolska, Agnieszka“…CASE PRESENTATION: We present a case of 39-year-old male with Factor V Leiden deficiency, who presented initially with symptoms of malnutrition and anasarca. …”
Publicado 2021
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898por Springer, Adrian, Schleberger, Ruben, Oyen, Florian, Hoffmann, Boris A., Willems, Stephan, Meyer, Christian, Langer, Florian, Schnabel, Renate B., Kirchhof, Paulus, Schneppenheim, Reinhard, Lemoine, Marc D.“…In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). …”
Publicado 2021
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900por Pluijmert, Niek J., de Jong, Rob C. M., de Vries, Margreet R., Pettersson, Knut, Atsma, Douwe E., Jukema, J. Wouter, Quax, Paul H. A.“…Unreperfused MI was induced by permanent ligation of the left anterior descending (LAD) coronary artery in hypercholesterolaemic APOE*3‐Leiden mice. Three weeks following MI, cardiac magnetic resonance (CMR) imaging showed a reduced LV end‐diastolic volume (EDV) by 21% and IS by 31% upon PC‐mAb treatment as compared to the vehicle control group. …”
Publicado 2021
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