“…The prevalence of the following genetic variants was determined: F5 c.1601G>A (factor V Leiden), F2 c.*97G>A (factor II or prothrombin mutation), F13A1 (factor XIII) c.103G>T, MTHFR (methylenetetrahydrofolate reductase) c.665C>T and c.1286A>C, as well as PAI-1 (plasminogen activator inhibitor 1) c.-816A>G and c.-844G>A as markers of thrombophilia risk, and *2 and *3 alleles of CYP2C9 (cytochrome P450 2C9) and five variants of VKORC1 (vitamin K epoxide reductase complex subunit 1) as markers of warfarin pharmacogenetics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHOD: Ethno-entomological information on Lepidoptera in sub-Saharan Africa was collected by (1) interviews with more than 300 people from about 120 ethnic groups in 27 countries in the region; and (2) library studies in Africa, London, Paris and Leiden. RESULTS: Often the interviewees indicated that people from his or her family or ethnic group did not know that caterpillars turn into butterflies and moths (metamorphosis). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hormones (glucose, insulin, thyroid-stimulating hormone, cortisol, and growth hormone) were measured in blood sampled every 10 min for 24 h in 38 participants of the Leiden Longevity Study. Four methods for detecting outliers were compared: (1) eyeballing, (2) Tukey’s fences, (3) stepwise approach, and (4) the expectation-maximization (EM) algorithm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Study design: Neonatal care providers of the Neonatal Intensive Care Unit (NICU) of Leiden University Medical Center reviewed recordings of neonatal resuscitation during weekly plenary audits since 2014. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TRIAL REGISTRATION: The study was approved by the Medical Ethical Review Board of the Leiden University Medical Center [P15.281].…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ETHICS AND DISSEMINATION: This study received ethical approval from the medical ethics committee in the Leiden University Medical Centre, the Netherlands (P16.048, ABR NL56308.058.16). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The AAA bank has been initiated by the two UMCs of Amsterdam UMC and by Leiden University Medical Center. Participants will be followed during AAA follow-up. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The aim of this study was to determine the effect of factor V (FV) gene polymorphisms (Leiden, G1691A [FVL] and HR2 A4070G) and to analyze their association with traditional risk factors in assessing the risk of CAD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The database dedicated to OPA1 (https://www.lovd.nl/OPA1), created in 2005, has now evolved towards a centralized and more reliable database using the Global Variome shared Leiden Open-source Variation Database (LOVD) installation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patients were interviewed 24 h after the operation using a Tigrigna translated Leiden Perioperative Care Patient Satisfaction questionnaire (LPPSq). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Among the 70 patients, 32 had MTHFR mutations, 10 had heterozygous factor V Leiden mutations, 4 had prothrombin mutations, 4 had protein S deficiency, 2 had protein C deficiency, 9 had AT deficiency, and 14 had APL-Abs. 40 patients had shunt occlusion. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both prothrombin G20210A mutation (odds ratio [OR], 2.43; 95% CI, 1.07‐5.53; P = 0.03) and factor V Leiden (FVL) (OR, 1.98; 95% CI, 1.06‐3.68; P = 0.03) were significantly associated with PVT risk. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: We carried out a population-based cohort study based on readily available routine healthcare data anonymously extracted from electronic medical records of 76 general practice centers in the Leiden area, the Netherlands. We included all patients aged 1–19 years on 31 December 2016 without prior mental health problems. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: From March 2012 until May 2016 we did a prospective observational cohort study in three radiology departments in the Leiden-The Hague area, The Netherlands. From adult patients we collected clinical characteristics and biomarkers, chest X ray results and outcome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Her only other medication was rivaroxaban for her homozygous Factor V Leiden deficiency. She had an extensive work up for causes of acute and unresolving hepatitis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Exploration of a possible prothrombotic state (complete blood count, haemostasis tests, activated protein C resistance, factor V Leiden, protein C, S, antithrombin III) gave normal results. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, we estimated the persistence of AF patients to VKA between 1 January 2004 and 1 January 2012 in data from the Anticoagulation Clinic Leiden. Non‐persistence was defined as the cumulative incidence of patients who completely stopped DOAC, switched to another oral anticoagulant or stopped their VKA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We investigated the effect of such lipid-lowering interventions on atherosclerosis in APOE*3-Leiden.CETP mice, a well-established model for hyperlipidemia. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso