“…METHODS: A population-based cohort study was conducted at the Leiden University Medical Center. IVF cycles of endometriosis patients and controls (unexplained infertility and tubal pathology) were analysed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: Population-based cohort study with anonymously extracted electronic healthcare data from preventive youth healthcare centers in the Leiden area, the Netherlands, from the period 2005–2015. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Seventy three per cent patients had risk factors; hyperhomocysteinemia in 52.1 per cent, protein S deficiency in 47.8 per cent, protein C deficiency in 19.4 per cent, MTHFR 677C→T mutation in 30.7 per cent, antinuclear antibody 11 per cent, and Factor V Leiden mutation in two per cent each. Thirty two per cent patients with hyperhomocysteinemia had no other thrombotic cause, and 22 per cent of them had either vitamin B12 and or folic acid deficiency only. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gene mutation of factor V Leiden was not detected both in non-VTE group and VTE group. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The last case depicts a severely ill COVID-19 patient with an inherited factor V Leiden mutation who required abnormally high dosing to achieve therapeutic anticoagulation, guided by TEG. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We then utilized VOSviewer (Centre for Science and Technology Studies, Leiden University, The Netherlands) to visualize our results and identify thematic, geographic, authorship/co-authorship, publication, and temporal trends. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Reliability of the E-diary diagnosis in combination with two previously validated E-questionnaires was compared to a physician’s diagnosis as gold standard in headache patients referred to the Leiden Headache Clinic (n = 596). In a subset of patients with migraine (n = 484), self-estimated migraine-related frequencies were compared to diary-based results. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The following risk factors were proved to be significantly associated with NAION: male gender (OR = 1.67, 95% CI: 1.50–1.85, P < 0.00001), hypertension (RR = 1.28, 95% CI: 1.20–1.37, P < 0.00001), hyperlipidemia (RR = 1.43, 95% CI: 1.26–1.62, P < 0.00001), diabetes mellitus (DM) (RR = 1.53, 95% CI: 1.36–1.73, P < 0.00001), coronary heart disease (CHD) (RR = 1.68, 95% CI: 1.24–2.27, P = 0.0008), sleep apnea (RR = 3.28, 95% CI: 2.08–5.17, P < 0.00001), factor V Leiden heterozygous (RR = 2.21, 95% CI: 1.19–4.09, P = 0.01), and medication history of cardiovascular drugs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MATERIAL AND METHODS: In this observational study, 438 neonates were included with HDFN, born ≥ 35 weeks gestational age at the Leiden University Medical Centre between January 2000 and July 2020. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CASE PRESENTATION: A 65-year-old female with a history of rheumatoid arthritis, factor V Leiden hypercoagulability, and prior saddle pulmonary embolism presented to the emergency department following a mechanical fall. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: Patients with metastases from STS, detected by (re)staging [(18)F]FDG-PET/CT at Leiden University Medical Centre, were retrospectively included. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this report, we screened the known “pathogenic” and “likely pathogenic” mutations in ABCA4 from available data in gnomAD, Leiden Open Variation Database (LOVD), and ClinVar for potential PAM sites of relevant base editors, including Streptococcus pyogenes Cas (SpCas), Staphylococcus aureus Cas (SaCas), and the KKH variant of SaCas (Sa-KKH). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To our knowledge, c.245T>C is a novel homozygous missense mutation in the MBTPS2 gene, which has not been reported in Human Gene Mutation Database, ClinVar Database, and Leiden Open Variation Database. Previous reports suggested genotype-phenotype correlations in the MBTPS2 gene mutations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: Eligible KTRs transplanted in Leiden University Medical Center were invited for this cross-sectional study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Variant classifications are publicly accessible via the Leiden Open Variation Database system (https://databases.lovd.nl/shared/genes/SDHB). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…FUNDING: This project received funding from the European Commission's Horizon2020 research and innovation program for H2020-MSCA-ITN IMforFUTURE, under grant agreement number 721815, and supported by Crowdfunding Wake Up To Corona, organized by the Leiden University Fund.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We assessed clinical and serological features associated with RA development in patients with an undifferentiated mono- or oligo-articular large joint arthritis, and with keen interest in whether an MRI of the small joints of the hand and foot would aid diagnosis. METHODS: Leiden Early Arthritis Clinic includes 4018 patients; this prospective study follows 221 consecutively included patients with new onset undifferentiated large joint arthritis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other hypercoagulability states were also investigated, with the antiphospholipid syndrome (APLA) showing the highest prevalence (11%) followed by other etiologies including oral contraceptive use, Factor V Leiden, prothrombin mutation, and malignancy. Selected JAK-2, APLA, and prothrombin mutation cases showed a more severe clinical course. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A systematic sampling technique was applied to select the study participants. Modified Leiden perioperative patient satisfaction tool was adapted to assess patients’ satisfaction with preoperative informed consent process. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: In this concealed, double‐blind, randomized controlled trial in medication overuse headache, conducted at the Leiden University Medical Centre, we compared the effect of maximal versus minimal behavioural intervention by a headache nurse during withdrawal therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso