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  1. 1141
    “…METHODS: Online survey of all practising midwives in the Netherlands using a validated measure of job satisfaction (the Leiden Quality of Work Questionnaire) to analyze the attitudes of hospital and primary-care midwives about their work. …”
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    Are midwives in the Netherlands satisfied with their jobs? A systematic examination of satisfaction levels among hospital and primary-care midwives in the Netherlands
  2. 1142
    “…ETHICS AND DISSEMINATION: This project is approved by the Medical Research Ethics Committee of the Leiden University Medical Center. No risks or burden are expected from the study. …”
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    Evaluating the role of paternal factors in aetiology and prognosis of recurrent pregnancy loss: study protocol for a hospital-based multicentre case–control study and cohort study (REMI III project)
  3. 1143
    “…Her medical history was remarkable for a heterozygous factor V Leiden mutation, elevated lipoprotein A, and a cerebral venous thrombosis (CVT) after oral contraceptive intake 15 years before. …”
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    Management of a decompensated acute-on-chronic intracranial venous sinus thrombosis
  4. 1144
    “…MATERIAL AND METHODS: From July 2002 to December 2015 at the Leiden University Hospital, the Netherlands, 69 young women underwent ovarian tissue cryopreservation when they were at risk of iatrogenic premature ovarian insufficiency. …”
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    Ovarian tissue cryopreservation: Low usage rates and high live‐birth rate after transplantation
  5. 1145
    “…METHODS: VL FFs were determined on longitudinal Dixon MRI scans from 2 natural history studies in Leiden University Medical Center (LUMC) and Cincinnati Children's Hospital Medical Center (CCHMC). …”
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    MRI vastus lateralis fat fraction predicts loss of ambulation in Duchenne muscular dystrophy
  6. 1146
    “…ETHICS AND DISSEMINATION: The study was approved by the Medical Research Ethics Committee Leiden Den Haag and Delft, and the Radboudumc Committee on Research Involving Human Subjects. …”
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    Risk factors for bleeding in haemato-oncology patients—a nested case–control study: The BITE study protocol (Bleeding In Thrombocytopenia Explained)
  7. 1147
    “…Multiparameter analysis using blood samples from patients with (anti)coagulation disorders indicated characteristic defects in thrombus formation, in cases of factor V, XI or XII deficiency; and in contrast, thrombogenic effects in patients with factor V-Leiden. Taken together, this integrative phenotyping approach of platelet–fibrin thrombus formation has revealed interaction mechanisms of platelet-primed key haemostatic pathways with alterations in patients with (anti)coagulation defects. …”
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    Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation
  8. 1148
    “…METHODS: A retrospective analysis was performed in 583 primary UM cases, enucleated at the Leiden University Medical Center between 1983 and 2013. …”
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    Prognostic Factors Five Years After Enucleation for Uveal Melanoma
  9. 1149
    “…PARTICIPANTS: Community‐dwelling older persons (mean age = 80.7 years; SD = 4.1 years) with mild cognitive deficits and using antihypertensive treatment, participating in the baseline measurement of the magnetic resonance imaging substudy (n = 210) of the Discontinuation of Antihypertensive Treatment in the Elderly Study Leiden. MEASUREMENTS: During home visits, BP was measured in a standardized way and apathy was assessed with the Apathy Scale (range = 0‐42). …”
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    Lower Blood Pressure, Small‐Vessel Disease, and Apathy in Older Persons With Mild Cognitive Deficits
  10. 1150
    “…We investigated mutations in genes responsible for clotting and fibrinolysis, including factor V (FV) Leiden, FV H1299R, factor II (FII) G20210A, methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C, factor XIII (FXIII) V34L, plasminogen activator inhibitor-1 (PAI-1) 4G/5G and endothelial protein C receptor (EPCR) H1 and H3 haplotypes using reverse polymerase chain reaction ViennaLab cardiovascular disease StrippAssays. …”
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    Combined presence of coagulation factor XIII V34L and plasminogen activator inhibitor 1 4G/5G gene polymorphisms significantly contribute to recurrent pregnancy loss in Serbian population
  11. 1151
    “…DESIGN AND SETTING: 2-month prospective cohort study, after the implementation of the APOP screener in ED routine care in the Leiden University Medical Center. SUBJECTS: all consecutive ED patients aged ≥70 years. …”
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    Feasibility and acceptability of the ‘Acutely Presenting Older Patient’ screener in routine emergency department care
  12. 1152
    “…All medical students in one of three MOOC integration designs at Leiden University Medical Center (LUMC) will be invited to participate. …”
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    Uncovering motivation and self-regulated learning skills in integrated medical MOOC learning: a mixed methods research protocol
  13. 1153
    “…METHODS AND RESULTS: APOE*3-Leiden.CETP mice with humanized lipoprotein metabolism were treated for 9 weeks with the selective β3-adrenergic receptor (AR) agonist CL316,243 to substantially activate brown fat. …”
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    Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development
  14. 1154
    “…CASE PRESENTATIONS: Case 1: A 33-year-old man with known heterozygous Factor V Leiden mutation and a remote history of deep vein thrombosis presented to his primary care physician's office with 2 days of mild pleuritic chest pain and a dry cough after a recent transcontinental flight. …”
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    Primary care physicians comprehensively manage acute pulmonary embolism without higher-level-of-care transfer: A report of two cases
  15. 1155
    “…METHODS: Levels of anti–topo I IgG, anti–topo I IgM, and anti–topo I IgA were assessed in consecutive serum samples obtained from patients at baseline who were positive for anti–topo I IgG in the Leiden Combined Care In Systemic Sclerosis (CCISS) cohort. …”
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    Association of Anti–Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti–Topoisomerase I–Positive Systemic Sclerosis
  16. 1156
    “…Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that systemic cholesterol lowering by oral atorvastatin or dietary restriction inhibits monocyte infiltration, and reverses macrophage accumulation in atherosclerotic plaques. …”
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    Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering
  17. 1157
    “…A total of 1105 coronary segments were analysed using QAngio XA 3D (Research Edition, Medis medical imaging systems, Leiden, The Netherlands). The combined volume of the major coronary arteries was significantly different between each group (1240 ± 476 mm(3) diabetic group, 1646 ± 391 mm(3) normal group, and 2072 ± 687 mm(3) abnormal group). …”
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    Quantitative evaluation and comparison of coronary artery characteristics by 3D coronary volume reconstruction
  18. 1158
    “…The mean liver excursion for the MMB group (1.42 ± 1.83 mm) was significantly higher than the DMB group (0.26 ± 0.38 mm) (p = 0.001). The mean Leiden-Surgical Rating Scale (L-SRS) rated by the two interventional radiologists were 4.5 ± 0.59 and 3.6 ± 0.85 for the DMB and MMB groups, respectively (p = 0.01). …”
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    Comparison of deep and moderate neuromuscular blockade in microwave ablation of liver tumours: a randomized-controlled clinical trial
  19. 1159
    “…In the current study we investigated the response of elafibranor in APOE*3Leiden.CETP mice, a translational animal model that displays histopathological characteristics of NASH in the context of obesity, insulin resistance and hyperlipidemia. …”
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    Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men
  20. 1160
    “…Prothrombin G20210A mutation, MTHFR mutation, Factor V Leiden mutation (VFL), antithrombin III (ATIII), protein C, S, and antiphospholipid antibodies, along with JAK2 RS V617F mutation by real-time polymerase chain reaction all were analyzed. …”
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    Janus Kinase-2 Mutation Associated Portal Vein Thrombosis Complicating Liver Cirrhosis and Hepatocellular Carcinoma
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