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  1. 1181
    “…Methods: All patients with a suspected benign/malignant bone tumor (BT), benign soft-tissue tumor (STT), or malignant soft-tissue sarcoma (STS) visiting the Leiden University Medical Center between 2016 and 2020 were invited to complete the Patient-Reported Outcomes Measurement Information System (PROMIS) 29-item profile questionnaire. …”
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    Health-Related Quality of Life of Bone and Soft-Tissue Tumor Patients around the Time of Diagnosis
  2. 1182
    “…ETHICS AND DISSEMINATION: The medical ethics committee Leiden-Den Haag-Delft (the Netherlands) has approved this trial. …”
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    Ruling out acute coronary syndrome in primary care with a clinical decision rule and a capillary, high-sensitive troponin I point of care test: study protocol of a diagnostic RCT in the Netherlands (POB HELP)
  3. 1183
    “…The patient had a history of heterozygous factor 5 Leiden mutation and abnormal lupus anticoagulant profile with development of a portal vein thrombus. …”
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    Transjugular intrahepatic portosystemic shunt-induced hemolysis in a non-cirrhotic patient: a case report
  4. 1184
    “…In a single-center retrospective cross-sectional cohort study, we analysed data on DXA and calcaneal QUS measurements systematically collected between 2011 and 2013 in all non-metastatic PCa patients attending our Uro-Oncological Clinic at the Leiden University Medical Center. Receiver operating characteristic curves were used to assess the positive (PPV) and negative (NPV) predictive values of QUS T-scores of 0, −1.0, and − 1.8 in identifying DXA-diagnosed osteoporosis (T-scores ≤ − 2.5 and ≤ −2) at lumbar spine and/or femoral neck. …”
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    Quantitative ultrasound of the calcaneus (QUS): A valuable tool in the identification of patients with non-metastatic prostate cancer requiring screening for osteoporosis
  5. 1185
    “…Methods: All STS patients surgically treated at the Leiden University Medical Center between 2000–2020 were included. …”
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    Follow-Up after Curative Surgical Treatment of Soft-Tissue Sarcoma for Early Detection of Recurrence: Which Patients Have More or Fewer Visits than Advised in Guidelines?
  6. 1186
    “…The author with the most articles published was Bax JJ (54 articles, 1.27%) from Leiden University Medical Center. The most cited article was titled “2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure”, with 138 citations. …”
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    The application of radiology for dilated cardiomyopathy diagnosis, treatment, and prognosis prediction: a bibliometric analysis
  7. 1187
    “…The primary outcome was the quality of surgical conditions evaluated with the Leiden-Surgical Rating Scale by the blinded surgeon. …”
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    Effect of epidural block on surgical conditions during pediatric subumbilical laparoscopic surgery involving a supraglottic airway: a randomized clinical trial
  8. 1188
    “…Surgery-related variables (the Leiden-Surgical Rating Scale (L-SRS), duration of the procedure) were recorded. …”
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    Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study
  9. 1189
    “…ETHICS: The original study protocol was approved by the medical research ethics committee Leiden Den Haag Delft on 26 November 2019. DISCUSSION: HD-MED is a low-risk study that will generate personalized PGx results that can immediately be implemented in clinical practice, thus potentially improving pharmacovigilance and patients’ quality of life. …”
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    Study protocol of the HD-MED study aiming to personalize drug treatment in Huntington’s disease: a longitudinal, observational study to assess medication use and efficacy in relation to pharmacogenetics
  10. 1190
    “…METHODS AND FINDINGS: We assessed APOE genotypes, plasma levels of apoE, cardiovascular risk factors, and mortality in a population-based sample of 546 individuals aged 85 y who participated in the Leiden 85-plus Study and were prospectively followed for specific causes of death for 5 y. …”
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    ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age
  11. 1191
    “…Among the genetic thrombophilia markers studied, Protein S (PS) deficiency was the strongest risk factor (RR 5.00 95% CI 3.02–5.00 P < 0.05) followed by factor V Leiden (FVL) mutation (RR 4.57 95% CI 2.23–4.57 P < 0.05) and PAI 4G/4G homozygosity (RR 3.24 95% CI 1.85–5.12 P < 0.05). …”
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    Deep venous thrombosis in the antenatal period in a large cohort of pregnancies from western India
  12. 1192
    “…The dosage of homocysteine, protein S and antithrombin was normal. FV Leiden and antiphospholipid antibodies were negative. …”
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    Neonatal arterial iliac thrombosis in type-I protein C deficiency: a case report
  13. 1193
    “…TRIAL REGISTRATION: This study was approved by The Ethical Committee of Faculty of Medicine, University of Indonesia, ref:194/PT02.FK/Etik/2006 and has been filed by ethics committee of the Leiden University Medical Center. Clinical trial number:ISRCTN83830814. …”
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    Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
  14. 1194
    “…METHODS: In all, 254 patients with completely resected (R0) UICC stage II colon cancer were analysed retrospectively from two independent cohorts from Munich (Germany) and Leiden (Netherlands). None of the patients received adjuvant treatment. …”
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    Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer
  15. 1195
    “…The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. …”
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    Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R
  16. 1196
    “…The objective of this study was to determine variations in the patient care process and patient flow among emergency physicians (EP’s) and internists at the ED of Leiden University Medical Centre (LUMC), the Netherlands. …”
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    Development of an observational instrument to determine variations in the patient care process and patient flow among emergency physicians and internists at the emergency department
  17. 1197
    “…Underlying etiologies consisted of congenital thrombophilia factors in 50% (28 cases) which was defined as protein C deficiency (12 cases), protein S deficiency (3 cases), antithrombin deficiency (3 cases) and factor V Leiden mutation (10 cases). Etiology was unknown in 18% (10 cases). …”
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    Long-term Outcome of Budd-Chiari Syndrome: A Single Center Experience
  18. 1198
    “…First, explorative analyses were performed on 600 RA-patients from Leiden. 109 SNPs, tagging OPG, RANK, RANKL and TRAF6, were tested. …”
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    A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis
  19. 1199
    “…We evaluated the effects of a broad dose range of anacetrapib on atherosclerosis and HDL function, and examined possible additive/synergistic effects of anacetrapib on top of atorvastatin in APOE*3Leiden.CETP mice. METHODS AND RESULTS: Mice were fed a diet without or with ascending dosages of anacetrapib (0.03; 0.3; 3; 30 mg/kg/day), atorvastatin (2.4 mg/kg/day) alone or in combination with anacetrapib (0.3 mg/kg/day) for 21 weeks. …”
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    Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin
  20. 1200
    “…TRIAL REGISTRATION: This study has been approved by the ethical committee of Faculty of Medicine Universitas Indonesia (ref: 549/H2.F1/ETIK/2013), and has been filed by the ethics committee of Leiden University Medical Center, clinical trial number: ISRCTN75636394. …”
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    Helminth infections and type 2 diabetes: a cluster-randomized placebo controlled SUGARSPIN trial in Nangapanda, Flores, Indonesia
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