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  1. 1261
    “…The associations of VTE with F5 factor V leiden (FVL) mutation, F2 G20210A prothrombin gene mutation (PGM), and polygenic score (PGS003332) were tested using Cox hazards regression analysis, adjusting for age at IBD diagnosis, gender, and genetic background (top 10 principal components). …”
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    Risk assessment of venous thromboembolism in inflammatory bowel disease by inherited risk in a population-based incident cohort
  2. 1262
    “…ETHICS AND DISSEMINATION: The Medical Ethical Committee Leiden-Den Haag-Delft (METC-LDD) approved this protocol (NL76563.058.21). …”
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    (Cost-)effectiveness of an individualised risk prediction tool (PERSARC) on patient’s knowledge and decisional conflict among soft-tissue sarcomas patients: protocol for a parallel cluster randomised trial (the VALUE-PERSARC study)
  3. 1263
    “…METHODS: In sera of 648 patients with RA and 538 patients without RA from the Leiden Early Arthritis Clinic, anti-MAA and anti-AGE IgG antibody levels were measured using ELISA. …”
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    Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association
  4. 1264
    “…METHODS: Using Thermo Scientific’s ImmunoCap ISAC (Immuno Solid-phase Allergen Chip) system, a multiplexed array that determines reactivities to 11 citrullinated peptides, we analysed serum/plasma of 195 healthy controls and 1282 early arthritis patients from two independent cohorts: the Leiden Early Arthritis Clinic (n = 1013) and the IMPROVED (n = 269) cohort. …”
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    An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting
  5. 1265
    “…VIPP-SD is an evidence-based parenting intervention developed at Leiden University in the Netherlands which uses a video-feedback approach to support parents, particularly by enhancing parental sensitivity and sensitive discipline in caring for children. …”
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    Preventing enduring behavioural problems in young children through early psychological intervention (Healthy Start, Happy Start): study protocol for a randomized controlled trial
  6. 1266
    por Cline, Melissa S., Liao, Rachel G., Parsons, Michael T., Paten, Benedict, Alquaddoomi, Faisal, Antoniou, Antonis, Baxter, Samantha, Brody, Larry, Cook-Deegan, Robert, Coffin, Amy, Couch, Fergus J., Craft, Brian, Currie, Robert, Dlott, Chloe C., Dolman, Lena, den Dunnen, Johan T., Dyke, Stephanie O. M., Domchek, Susan M., Easton, Douglas, Fischmann, Zachary, Foulkes, William D., Garber, Judy, Goldgar, David, Goldman, Mary J., Goodhand, Peter, Harrison, Steven, Haussler, David, Kato, Kazuto, Knoppers, Bartha, Markello, Charles, Nussbaum, Robert, Offit, Kenneth, Plon, Sharon E., Rashbass, Jem, Rehm, Heidi L., Robson, Mark, Rubinstein, Wendy S., Stoppa-Lyonnet, Dominique, Tavtigian, Sean, Thorogood, Adrian, Zhang, Can, Zimmermann, Marc, Burn, John, Chanock, Stephen, Rätsch, Gunnar, Spurdle, Amanda B.
    Publicado 2018
    “…The data set is based on shared information from existing clinical databases—Breast Cancer Information Core (BIC), ClinVar, and the Leiden Open Variation Database (LOVD)—as well as population databases, all linked to a single point of access. …”
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    BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
  7. 1267
    “…(low‐density lipoprotein receptor)–null Leiden mice underwent femoral artery ligation and received treatment with llama antibodies 2H8 or 2C10 or with vehicle. …”
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    Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single‐Domain Llama‐Derived Antibody
  8. 1268
    “…The LV global longitudinal (LV LGS) and circumferential strain (LV CS) were calculated using CMR feature tracking (CMR-FT) software (Medis Suite QStrain 2.0, Medis Medical Imaging Systems B.V., Leiden, The Netherlands). The LV fibrosis expansion was assessed using a late gadolinium enhancement sequence. …”
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    Left Ventricular Morphology and Function as a Determinant of Pulmonary Hypertension in Patients with Severe Aortic Stenosis: Cardiovascular Magnetic Resonance Imaging Study
  9. 1269
    “…METHODS: This is a prospective, observational study conducted at Leiden University Medical Center. Patients with and patients without heart failure undergoing cardiac surgery on cardiopulmonary bypass are enrolled. …”
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    Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study
  10. 1270
    “…METHODS: Children of two grade-three groups (age 8–9) following regular primary education in Leiden, The Netherlands, were recruited. A coin toss determined which group is the experimental group; the other group is the control group. …”
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    A good beginning: study protocol for a group-randomized trial to investigate the effects of sit-to-stand desks on academic performance and sedentary time in primary education
  11. 1271
    “…DESIGN, SETTING, AND PARTICIPANTS: This study was an investigator-initiated, single-center, nonblinded, feasibility, randomized clinical trial conducted at the Department of Cardiology of the Leiden University Medical Center between May 2016 and December 2018. …”
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    Effect of Smartphone-Enabled Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial Infarction: A Randomized Clinical Trial
  12. 1272
    “…PARTICIPANTS: 170 randomly selected universities from the Leiden ranking of world universities list. MAIN OUTCOME MEASURE: Presence of five traditional (for example, number of publications) and seven non-traditional (for example, data sharing) criteria in guidelines for assessing assistant professors, associate professors, and professors and the granting of tenure in institutions with biomedical faculties. …”
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    Academic criteria for promotion and tenure in biomedical sciences faculties: cross sectional analysis of international sample of universities
  13. 1273
    “…METHODS: We conducted a qualitative study with individual interviews using a grounded theory approach, involving 13 purposively sampled first-year medical students at Leiden University Medical Center. RESULTS: Our results suggest that first-year students are already able to identify many aspects of research. …”
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    Promoting positive perceptions of and motivation for research among undergraduate medical students to stimulate future research involvement: a grounded theory study
  14. 1274
    “…The secondary outcomes are serum creatinine level, intraoperative urine output, erythrocytes in urinary sediment, renal tissue oxygen saturation, Leiden’s surgical condition rating scale, surgery duration, and occurrence of bucking or body movement. …”
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    Effect of pneumoperitoneum pressure and the depth of neuromuscular block on renal function in patients with diabetes undergoing laparoscopic pelvic surgery: study protocol for a double-blinded 2 × 2 factorial randomized controlled trial
  15. 1275
    “…We then used the VOSviewer (Leiden University) tool to construct and visualize the co-occurrence networks of researchers, research institutions, countries/regions, citations, and keywords. …”
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    Theme Trends and Knowledge Structure on Mobile Health Apps: Bibliometric Analysis
  16. 1276
    “…This study is part of a project that aims at addressing these challenges and is carried out by teams from Mbarara University of Science and Technology (MUST) in Uganda, Leiden University Medical Center (LUMC) in the Netherlands, Delft University of Technology (TU Delft) in the Netherlands and Pennsylvania State University (PSU) in the USA. …”
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    Adaptive-size dictionary learning using information theoretic criteria for image reconstruction from undersampled k-space data in low field magnetic resonance imaging
  17. 1277
    “…Patients completed four validated questionnaires, assessing healthcare utilization and costs over the previous 12 months (Medical Consumption Questionnaire), disease bother and needs (Leiden Bother and Needs Questionnaire Pituitary), HRQoL (Short Form-36), and self-reported health status (EuroQol 5D). …”
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    Healthcare utilization and costs among prolactinoma patients: a cross-sectional study and analysis of determinants
  18. 1278
    “…METHODS: Tumor samples from patients who underwent primary tumor resection and neck dissection between 1995 and 2013, were collected from the archives of the Leiden and Erasmus University Medical Center. Immunohistochemistry with D1C2 was performed to identify MET negative (< 10% uniform positivity) and MET positive (≥ 10% uniform positivity) cancers. …”
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    The Potential of MET Immunoreactivity for Prediction of Lymph Node Metastasis in Early Oral Tongue Squamous Cell Carcinoma
  19. 1279
    “…Assessments were performed manually (QMass, Medis Medical Imaging Systems, Leiden, Netherlands) by an experienced (3 years) and inexperienced reader (no active reporting, 45 min of training with five cases from the SCMR consensus data) as well as fully automated (suiteHEART, Neosoft, Pewaukee, WI, USA) without any manual corrections. …”
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    Impact of fully automated assessment on interstudy reproducibility of biventricular volumes and function in cardiac magnetic resonance imaging
  20. 1280
    “…METHOD: The TULIPS Consortium consists of four population-based studies in oldest-old individuals: Leiden 85-plus Study, LiLACS NZ, Newcastle 85+ study, and TOOTH. …”
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    The effects of single and a combination of determinants of anaemia in the very old: results from the TULIPS consortium
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