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1281por de Vries, M. R., Ewing, M. M., de Jong, R. C. M., MacArthur, M. R., Karper, J. C., Peters, E. A. B., Nordzell, M., Karabina, S. A. P., Sexton, D., Dahlbom, I., Bergman, A., Mitchell, J. R., Frostegård, J., Kuiper, J., Ninio, E., Jukema, J. W., Pettersson, K., Quax, P. H. A.“…In vivo testing was performed in a femoral artery cuff model in ApoE3*Leiden mice. Safety studies are performed in rats and cynomolgus monkeys. …”
Publicado 2021
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1282por Meijer-Boekel, Caroline, van den Akker, M.Elske, van Bodegom, Leti, Escher, Johanna, van Geloven, Nan, van Overveld, Floris, Rings, Edmond H H.M, Smit, Lucy, de Vries, Martine Charlotte, Mearin, M. Luisa“…ETHICS AND DISSEMINATION: The Medical Ethics Committee Leiden approved this study. If we prove that case finding at the YHCC is feasible, cost-effective and well accepted by the population, implementation is recommended. …”
Publicado 2021
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1283por Harder, Aster V.E., Winsvold, Bendik S., Noordam, Raymond, Vijfhuizen, Lisanne S., Børte, Sigrid, Kogelman, Lisette J.A., de Boer, Irene, Tronvik, Erling, Rosendaal, Frits R., Willems van Dijk, Ko, O'Connor, Emer, Fourier, Carmen, Thomas, Laurent F., Kristoffersen, Espen S., Fronczek, Rolf, Pozo‐Rosich, Patricia, Jensen, Rigmor H., Ferrari, Michel D., Hansen, Thomas F., Zwart, John‐Anker, Terwindt, Gisela M., van den Maagdenberg, Arn M.J.M“…METHODS: We conducted a case–control study in the Dutch Leiden University Cluster headache neuro‐Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). …”
Publicado 2021
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1284por Souri, Zahra, Wierenga, Annemijn P. A., Kiliç, Emine, Brosens, Erwin, Böhringer, Stefan, Kroes, Wilma G. M., Verdijk, Robert M., van der Velden, Pieter A., Luyten, Gregorius P. M., Jager, Martine J.“…The expression of 125 miRNAs was determined in 64 primary UM from Leiden. Similarly, the mRNA expression of HLA-A, HLA-B, TAP1, BAP1, and immune cell markers was obtained. …”
Publicado 2021
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1285por Warmerdam, Britt W. C. M., van Holstein, Yara, Eefting, Daniël, van Rijswijk, Carla S. P., van der Meer, Rutger W., Mooijaart, Simon P., Hamming, Jaap F., van der Vorst, Joost R., van Schaik, Jan“…MATERIALS AND METHODS: A single-center retrospective cohort study was performed, using data from a computerized database of consecutive patients who underwent complex EVAR in the Leiden University Medical Center (LUMC, The Netherlands) between July 2013 and September 2020. …”
Publicado 2021
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1286por Roest, S. L., Siebelink, B. M., van Ewijk, H., Vermeiren, R. R. J. M., Middeldorp, C. M., van der Lans, R. M.“…METHODS: Routinely collected data from 2013 to 2018 of 2715 outpatients in the Greater Area of Brisbane, Australia (CYMHS) and 1158 outpatients in Leiden, the Netherlands (LUMC-Curium) were analysed. …”
Publicado 2021
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1287“…The discovery of a tomato specimen in the sixteenth-century ‘En Tibi herbarium’ kept at Leiden, the Netherlands, triggered research on its geographical provenance and morphological comparison to other tomato specimens and illustrations from the same time period. …”
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1288por de Jong, Yvonne, Boon, Albert E., Gouw, Daniek, van der Gaag, Mark, Mulder, Cornelis L.“…Trial registration Permission was asked according to the rules of the Ethics Committee at Leiden. This study is registered as NL.44180.058.13…”
Publicado 2022
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1289“…RESULTS: Based upon the inclusion criteria, the following 10 sexual health screening tools were identified and reviewed: Female Sexual Function Index, European Organization for Research and Treatment of Cancer Quality of Life Questionnaires for both Cervical and Endometrial Cancer, Sexual Adjustment and Body Image Scale, Sexual Adjustment and Body Image Scale- Gynecologic Cancer, Sexual Function and Vaginal Changes Questionnaire, Gynaecologic Leiden Questionnaire, Information on Sexual Health: Your Needs after Cancer, Sexual Satisfaction Questionnaire, and Sexual Activity Questionnaire. …”
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1290por van de Vijver, Paul L., Schalkwijk, Frank H., Numans, Mattijs E., Slaets, Joris P. J., van Bodegom, David“…METHODS: We evaluated the effects of linking a peer coach physical activity intervention in Leiden, The Netherlands to primary care through an exercise referral scheme from July 2018 to April 2020. …”
Publicado 2022
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1291por Loke, Yue-Hin, Capuano, Francesco, Kollar, Sarah, Cibis, Merih, Kitslaar, Pieter, Balaras, Elias, Reiber, Johan H. C., Pedrizzetti, Gianni, Olivieri, Laura“…Feature-tracking software (QStrain 2.0, Medis Medical Imaging Systems, Leiden, Netherlands) captured endocardial contours from long/short-axis cine and used to reconstruct RV wall motion. …”
Publicado 2022
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1292por Dijk, Wieneke, Di Filippo, Mathilde, Kooijman, Sander, van Eenige, Robin, Rimbert, Antoine, Caillaud, Amandine, Thedrez, Aurélie, Arnaud, Lucie, Pronk, Amanda, Garçon, Damien, Sotin, Thibaud, Lindenbaum, Pierre, Ozcariz Garcia, Enrique, Pais de Barros, Jean-Paul, Duvillard, Laurence, Si-Tayeb, Karim, Amigo, Nuria, Le Questel, Jean-Yves, Rensen, Patrick C.N., Le May, Cédric, Moulin, Philippe, Cariou, Bertrand“…To uncover the mechanisms underlying the combined hypocholesterolemia, we used protein homology modeling, measured triglyceride lipase and phospholipase activities in cell culture, and studied the phenotype of APOE*3.Leiden.CETP mice after LIPC-E97G overexpression. RESULTS: Family members carrying the LIPC-E97G variant had very low circulating levels of LDL cholesterol and high-density lipoprotein cholesterol, LDL particle numbers, and phospholipids. …”
Publicado 2022
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1293por Algie, Jelle P. A., van Kooten, Robert T., Tollenaar, Rob A. E. M., Wouters, Michel W. J. M., Peeters, Koen C. M. J., Dekker, Jan Willem T.“…METHODS: All patients who underwent sphincter-sparing surgical resection for rectal cancer in the Leiden University Medical Center and the Reinier de Graaf Gasthuis between January 2012 and January 2016 were included. …”
Publicado 2022
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1294por Valenti, Luca, Tripodi, Armando, La Mura, Vincenzo, Pelusi, Serena, Bianco, Cristiana, Scalambrino, Erica, Margarita, Sara, Malvestiti, Francesco, Ronzoni, Luisa, Clerici, Marigrazia, D’Ambrosio, Roberta, Fraquelli, Mirella, Carpani, Rossana, Prati, Daniele, Peyvandi, Flora“…Both rs687289 ABO and factor V Leiden were independently associated with higher Pro-C3 (p <0.025), with the effect of ABO being mediated by the impact on vWF (p = 5E-10 for association with Pro-C3). …”
Publicado 2022
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1295Research trends and hotspots of recurrent pregnancy loss with thrombophilia: a bibliometric analysispor Deng, Ying-jun, Liu, Sheng-Jing, Zhao, Ming, Zhao, Feng, Guo, Jun, Huang, Yu-xiao“…In keyword and clusters, factor-v-Leiden, inherited thrombophilia, activated protein-c, low-dose aspirin, molecular-weigh heparin, polymorphism had high-frequency focus on its etiology, diagnostics, and therapeutics. …”
Publicado 2022
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1296por Rayo, Enrique, Neukamm, Judith, Tomoum, Nadja, Eppenberger, Patrick, Breidenstein, Abagail, Bouwman, Abigail S., Schuenemann, Verena J., Rühli, Frank J.“…The samples were obtained from museum collections in Berlin (DE), Burgdorf (DE), Leiden (NE), Manchester (UK), Munich (DE), St. Gallen (CH), Turin (IT), and Zagreb (HR). …”
Publicado 2022
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1297por Koemans, Emma A., Castello, Juan Pablo, Rasing, Ingeborg, Abramson, Jessica R., Voigt, Sabine, Perosa, Valentina, van Harten, Thijs W., van Zwet, Erik W., Terwindt, Gisela M., Gurol, M. Edip, Rosand, Jonathan, Greenberg, Steven M., van Walderveen, Marianne A.A., Biffi, Alessandro, Viswanathan, Anand, Wermer, Marieke J.H.“…METHODS: Patients with D-CAA and sCAA were included from hospital and research databases of the Leiden University Medical Center (2012–2020) and Massachusetts General Hospital (1994–2012). …”
Publicado 2023
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1298por Wójcik, Krzysztof, Bazan-Socha, Stanisława, Celejewska-Wójcik, Natalia, Górka, Karolina, Lichołai, Sabina, Polok, Kamil, Stachura, Tomasz, Zaręba, Lech, Dziedzic, Radosław, Gradzikiewicz, Ada, Sanak, Marek, Musiał, Jacek, Sładek, Krzysztof, Iwaniec, Teresa“…PATIENTS AND METHODS: In 118 adult Caucasian severe but non-critically ill COVID-19 patients (median age 58 years; 73 % men) and 46 controls, we analyzed in vitro plasma thrombin generation profile (calibrated automated thrombogram [CAT assay]) and investigated thrombophilia-related factors, such as protein C and antithrombin activity, free protein S level, presence of antiphospholipid antibodies and factor V Leiden R506Q and prothrombin G20210A mutations. We also measured circulating von Willebrand factor (vWF) antigen and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) antigen and activity. …”
Publicado 2023
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1299por Monahan, Rory C, Beaart-van de Voorde, Liesbeth J J, Fronczek, Rolf, de Bresser, Jeroen, Eikenboom, Jeroen, Kloppenburg, Margreet, Middelkoop, Huub A M, Terwindt, Gisela M, van der Wee, Nic J A, Huizinga, Tom W J, Steup-Beekman, Gerda M“…METHODS: All patients with SLE visiting the Leiden University Medical Centre NPSLE clinic between 2007 and 2021 receiving immunosuppressive therapy for neuropsychiatric symptoms were included. …”
Publicado 2023
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1300“…Combining this dataset with the yeast protein–protein interaction network from STRING, we were able to perform a variety of analyses and visualizations from within clusterMaker2, including Leiden clustering to break the entire network into smaller clusters, hierarchical clustering to look at the overall expression dataset, dimensionality reduction using UMAP to find correlations between our hierarchical visualization and the UMAP plot, fuzzy clustering, and cluster ranking. …”
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