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  1. 5981
    “…The cellular assays of the tREP-18 peptide on the BS12 strain, a clinical isolate of post-kala azar dermal leishmaniasis, demonstrated its significant efficacy at an IC50 value of 15 nM. …”
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    tREPs—A New Class of Functional tRNA-Encoded Peptides
  2. 5982
    “…KEGG pathway enrichment analysis indicated that Staphylococcus aureus infection, osteoclast differentiation, leishmaniasis, and ECM-receptor interaction were significantly altered in septic hearts. …”
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    Time Series Transcriptomic Analysis by RNA Sequencing Reveals a Key Role of PI3K in Sepsis-Induced Myocardial Injury in Mice
  3. 5983
    “…The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory molecules. …”
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    Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase
  4. 5984
    “…Protozoan parasites of the genus Leishmania causes Leishmaniasis, a neglected disease affecting over 12 million people worldwide. …”
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    Ligand-induced structural transitions combined with paramagnetic ions facilitate unambiguous NMR assignments of methyl groups in large proteins
  5. 5985
    por Cui, Xiao-Yan, Wu, Xiao, Lu, Dan, Wang, Dan
    Publicado 2022
    “…CONCLUSION: SQHJ treatment for DM targets TP53, AKT1, CASP3, and TNF and participates in pathways in leishmaniasis and cancer.…”
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    Network pharmacology-based strategy for predicting therapy targets of Sanqi and Huangjing in diabetes mellitus
  6. 5986
    “…These results together suggested L1 has a potential effect against L. amazonensis, the etiologic agent of diffuse leishmaniasis, and the only one that currently does not have a satisfactory treatment.…”
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    Quantum Biochemistry Screening and In Vitro Evaluation of Leishmania Metalloproteinase Inhibitors
  7. 5987
    “…We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 linear chain, but not higher, along with a carboxyl/ester group showed a similar anti-leishmanial effect. …”
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    Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani
  8. 5988
    “…The severity of various infectious diseases including visceral leishmaniasis (VL), influenza, and tuberculosis is associated with undernutrition. …”
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    Thymus, undernutrition, and infection: Approaching cellular and molecular interactions
  9. 5989
    “…Leishmaniasis is one of the main infectious diseases worldwide. …”
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    Bioinformatics analysis for the purpose of designing a novel multi-epitope DNA vaccine against Leishmania major
  10. 5990
    “…Lung cancer and cutaneous leishmaniasis are critical diseases with a relatively higher incidence in developing countries. …”
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    Human Lung Cancer (A549) Cell Line Cytotoxicity and Anti-Leishmania major Activity of Carissa macrocarpa Leaves: A Study Supported by UPLC-ESI-MS/MS Metabolites Profiling and Molecular Docking
  11. 5991
    “…Visceral leishmaniasis (VL) is a disease caused by Leishmania parasites. …”
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    Detection of asymptomatic Leishmania infection in blood donors at two blood banks in Ethiopia
  12. 5992
    “…The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a concerted effort to find new leads. …”
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    Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling
  13. 5993
    “…In leishmaniasis, the protective immunity is largely mediated by proinflammatory cytokine producing abilities of T cells and an efficient parasite killing by phagocytic cells. …”
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    Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4(+) T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens
  14. 5994
    “…Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl(2)(H3)(2) complex. …”
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    Zinc(II)-Sterol Hydrazone Complex as a Potent Anti-Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action
  15. 5995
    “…Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3′,5,5′-Tetramethoxy-biphenyl-4,4′-diol (TMBP) was synthesized through laccase-catalysis of 2,6-dimethoxyphenol and displayed antioxidant and anticancer activity, and is considered a potential drug candidate. …”
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    In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential
  16. 5996
    “…The outcome of the disease visceral leishmaniasis (VL), caused by Leishmania donovani (LD), largely relies on the relative dominance of host-protective type-1 T helper (Th1) cell response versus disease-promoting type-2 T helper (Th2) cell response. …”
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    TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3
  17. 5997
    “…ABSTRACT: Visceral canine leishmaniasis (CanL) can cause several clinical manifestations, including neurological lesions. …”
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    Increased CCL-5 (RANTES) Gene Expression in the Choroid Plexus of Dogs with Canine Leishmaniosis
  18. 5998
    “…Suggesting their potential as prognostic markers for severe leishmaniasis and promising target molecules for therapeutic interventions, this research opens new avenues for combatting this debilitating parasitic disease. …”
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    Detection and activity of MMP-2 and MMP-9 in Leishmania amazonensis and Leishmania braziliensis promastigotes
  19. 5999
    “…The signal pathways mainly involved include Lipid and atherosclerosis, IL-17 signaling pathway, Chagas disease, leishmaniasis, and TNF signaling pathway. Moreover, molecular docking showed that the 2 most active compounds, Astragaloside IV and kaempferol, could efficiently bind with the targets TNF, TLR4, and IL10. …”
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    Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking
  20. 6000
    “…BACKGROUND: Morphological involvement of endocrine glands, such as the pituitary gland, remain uninvestigated in dogs with canine visceral leishmaniasis. Therefore, this study investigated the presence of amastigotes of Leishmania spp. and characterized inflammatory changes, highlighting the involvement of TCD3(+) lymphocytes in different regions of the pituitary gland of dogs. …”
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    Lymphocytic hypophysitis in dogs infected with Leishmania spp.
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