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    “…The genome of a PN-affected Leonberger homozygous for the associated haplotype was sequenced and variants in the 7.7 Mb sized critical interval were identified. …”
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    “…An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT) disease in humans. …”
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    por Hayek, Salim S, Brenner, Samantha K, Azam, Tariq U, Shadid, Husam R, Anderson, Elizabeth, Berlin, Hanna, Pan, Michael, Meloche, Chelsea, Feroz, Rafey, O’Hayer, Patrick, Kaakati, Rayan, Bitar, Abbas, Padalia, Kishan, Perry, Daniel, Blakely, Pennelope, Gupta, Shruti, Shaefi, Shahzad, Srivastava, Anand, Charytan, David M, Bansal, Anip, Mallappallil, Mary, Melamed, Michal L, Shehata, Alexandre M, Sunderram, Jag, Mathews, Kusum S, Sutherland, Anne K, Nallamothu, Brahmajee K, Leaf, David E, Malik, A Bilal, Bitar, Abbas, Abu-Saif, Abeer, Green, Adam, Ahoubim, Afshin, Oyintayo, Ajiboye, Jose, Aju, Athreya, Akshay, Jacobs, Alanna L, Fornoni, Alessia, Hodakowski, Alexander J, Leidner, Alexander S, Shehata, Alexandre M, Iardino, Alfredo, Friedman, Allon N, Renaghan, Amanda D, Leonberg-Yoo, Amanda K, Bansal, Amar D, Athavale, Ambarish M, Podoll, Amber S, Azhar, Ambreen, Patrawalla, Amee, Pannu, Ameeka, Zhou, Amy M, Srivastava, Anand, Admon, Andrew J, Vissing, Andrew, Bansal, Anip, Vijayan, Anitha, Hasty, Anna E, Sutherland, Anne K, Faugno, Anthony J, Saha, Aparna, Williams, Aquino, Rashidi, Arash, Mueller, Ariel L, Kapoor, Aromma, Tolwani, Ashita, Macina, Ashley, Tariq, Asma, Ahmed, Ayesha, Danek, Barbara A, Wu, Benjamin, Shukla, Bhavarth, Mehta, Bijal, Brown, Brent R, Garibaldi, Brian T, Schulze, Carl E, Walther, Carl P, Martinez, Carlos, Hsu, Caroline M, Corona-Villalobos, Celia P, Vasquez, Charles R, Meloche, Chelsea, Shah, Chintan V, Parikh, Chirag R, Rowan, Chris, Schorr, Christa A, Joy, Christina Mariyam, Mosher, Christopher L, Meshberger, Christopher, Kovesdy, Csaba P, Weiner, Daniel E, Edmonston, Daniel L, Perry, Danny, Hall, Danyell, Charytan, David, De La Zerda, David, Leaf, David E, Zonies, David, Altman, Deena R, Lazarous, Deepa G, Zhu, Denzel, Sirganagari, Dheeraj Reddy, Pan, Di, Finkel, Diana G, Willett, Duwayne L, Price-Haywood, Eboni G, Schenck, Edward J, Cervantes, Carmen Elena, Anderson, Elizabeth, Au, Elizabeth H, Burnham, Ellen L, Leven, Emily A, Chang, Emily H, Gallagher, Emily J, Judd, Eric, Newman, Erik T, Yap, Ernie, Kapania, Esha M, Kim, Ethan C, Macedo, Etienne, Madhani-Lovely, Farah, Modersitzki, Frank, Contreras, Gabriel, Naimy, Gabriel, Bambrick-Santoyo, Gabriela, Nadkarni, Girish N, Mosoyan, Gohar, Katz-Greenberg, Goni, Schumaker, Greg L, Milligan, Gregory P, Nguyen, H Bryant, Berlin, Hanna, Rhee, Harin, Singh, Harkarandeep, Gershengorn, Hayley B, Yang, Heather, Soh, Howard, Wen, Huei Hsun, Chen, Huiwen, Shadid, Husam, Strohbehn, Ian A, Mohamed, Ibrahim, Berim, Ilya, Puri, Isha, Vohra, Ishaan, Kruser, Jacqueline M, Sunderram, Jag, Lash, James P, Krishnan, Jamuna, Radbel, Jared, Adams, Jason Y, Shah, Jatan A, Neyra, Javier A, Koyner, Jay L, Vatson, Jayanth S, Rachoin, Jean-Sebastien, Boateng, Jeffery O, Paer, Jeffrey M, Flythe, Jennifer E, Griffiths, Jennifer, Rodriguez, Jesus, Li, Jiahua, Ouyang, Jie, Sharma, Jill H, Wang, Jing G, Zhang, Jingjing, Reiser, Jochen, Guirguis, John, Byun, John J, Donnelly, John P, Wagner, John, Levitt, Joseph E, Hermes, Joy-Marie, Velez, Juan Carlos Q, Valencia, Juan D, Arunthamakun, Justin, Thakkar, Jyotsana, Bhattacharya, Jyotsna, Sedaliu, Kaltrina, Prudhvi, Kalyan, Pokharel, Kapil K, Senter, Katharine, Kelly, Katherine J, Liu, Kathleen D, Kopecky, Kathleen F, Rose, Keith M, Kashani, Kianoush, Padalia, Kishan J, Hess, Kristen M, Mathews, Kusum S, Enfield, Kyle B, Golestaneh, Ladan, Bickley, Laura, Latta, Laura, Meyer, Leah, Boudourakis, Leon, Thomas, Leslie F, Chan, Lili, Shea, Lisa, Matute-Trochez, Luis A, Gomez-Escobar, Luis G, Elias, Madona, Plataki, Maria, Thaxton, Mariah, Sosa, Marie Anne, Liotta, Mark, Christov, Marta, Mallappallil, Mary C, Tugman, Matthew J, Scharf, Matthew T, Semler, Matthew W, Brogan, Maureen, Roche, Meaghan S, Krajewski, Megan L, Sise, Meghan E, Lee, Meghan, Chang, Michael, Pan, Michael, Melamed, Michal L, Chonchol, Michel, Hernán, Miguel A, Molnar, Miklos Z, Yunes, Milagros, Joo, Min J, Sharshir, Moh’d A, Farag, Mohamed, Fisher, Molly, Nadamuni, Mridula V, Gupta, Mrigank S, Ali, Muhammad Imran, Mohamed, Muner MB, Ernecoff, Natalie C, Kumar, Neelja, Cairl, Nicholas S, Patel, Nilam P, Goyal, Nitender, ul aain Bhatti, Noor, Chaaban, Nourhan, Kamal, Omer, Garcia, Pablo, Kao, Patricia F, Walters, Patricia, O’ Hayer, Patrick, Pattharanitima, Pattharawin, Bergl, Paul A, Bhatraju, Pavan K, Blakely, Pennelope, Wilson, Perry, McCullough, Peter A, Cangialosi, Peter, Hart, Peter, Guru, Pramod K, Kumar, Princy N, Feroze, Rafey, Kapoor, Rajat, Hejal, Rana, Kshirsagar, Ravi K, Kaakati, Rayan, Lisk, Rebecca, Beutler, Rebecca M, Levy, Rebecca V, Wunderink, Richard G, Raichoudhury, Ritesh, Redfern, Roberta E, Go, Ronaldo C, Malik, Rubab F, Song, Rui, Avasare, Rupali S, Mocerino, Ryan, Spiardi, Ryan C, Hedayati, S Susan, Taldone, Sabrina, John, Sabu, Hayek, Salim S, Abu Omar, Samah, Brenner, Samantha K, Anumudu, Samaya J, Gautam, Samir C, Short, Samuel AP, Woo, Sang Hoon, Kapoor, Sanjana, Gupta, Sanjeev, Kassaye, Seble G, Alvarez-Mulett, Sergio L, Goldberg, Seth, Tehranian, Shahrzad, Shaefi, Shahzad, Shastri, Shani, Sharma, Shreyak, Upadhyay, Shristi, Gupta, Shruti, Anand, Shuchi, Bajracharya, Siddhartha, Verma, Siddharth, Shankar, Sidharth, Correa, Simon, Chaudhry, Sobaata, Bose, Sonali, Puri, Sonika, Cho, Soo Jung, Arikapudi, Sowminya, Lee, Stefi, Toth-Manikowski, Stephanie M, Coca, Steven G, Menez, Steven, Chang, Steven Y, Sharma, Sunita, Waikar, Sushrut S, Boyle, Suzanne M, Arora, Tanima, Ferreira, Tanira, Shaukat, Tanveer, Johns, Tanya S, Azam, Tariq U, Nguyen, Thuy-Duyen, Albertson, Timothy E, Li, Tingting, Miano, Todd A, Ugwuowo, Ugochukwu, Rusnak, Vadym V, Allusson, Valerie, Jotwani, Vasantha K, Peev, Vasil, Jaikaransingh, Vishal, Cruz, Vivian S, Wang, Wei, Whalen, William, Deng, Xiaoying, Ahmad, Yahya, Zhou, Yan, Melaku, Yohannes, Azzi, Yorg, Wen, Yumeng, Cohen, Zaza, Kibbelaar, Zoe A, Post, Zoe
    Publicado 2020
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    “…Canine leukoencephalomyelopathy (LEMP) is a juvenile-onset neurodegenerative disorder of the CNS white matter currently described in Rottweiler and Leonberger dogs. Genome-wide association study (GWAS) allowed us to map LEMP in a Leonberger cohort to dog chromosome 18. …”
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    “…The purpose of this study was to discover the underlying genetic and molecular mechanisms in a younger-onset form of this neurodegenerative disease seen in two closely related giant dog breeds, the Leonberger and Saint Bernard. Neuropathology of an affected dog from each breed showed variable nerve fiber loss and scattered inappropriately thin myelinated fibers. …”
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    “…Breeds with the highest annual prevalence were the Scottish Deerhound (3.28%, 95% CI 0.90–8.18), Leonberger (1.48%, 95% CI 0.41- 3.75), Great Dane (0.87%, 95% CI 0.43- 1.55) and Rottweiler (0.84%, 95% CI 0.64–1.07). …”
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    “…METHODS: A cohort study of 585 privately owned dogs of four breeds: Newfoundland, Labrador retriever, Leonberger, and Irish wolfhound. The owners maintained a continuous log regarding housing, exercise, nutrition, and health of their dogs. …”
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    “…A distinct three-locus risk haplotype (DLA-DRB1*001:01/DQA1*001:01/DQB1*002:01) was associated with AD in the West Highland white terrier and Leonberger. Two different risk haplotypes were associated with increased risk for SLO in the bearded collie (DLA-DRB1*018:01/DQA1*001:01/DQB1*002:01 and DLA-DRB1*018:01/DQA1*001:01/ DQB1*008:02). …”
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