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1por Northrop, John H.“…Constant small quantities (0.1 to 100 micrograms per hour) of mustard (H) or lewisite (L) gas may be obtained by allowing the vapor to diffuse through a porous alundum plug of suitable dimensions. …”
Publicado 1948
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3“…Results: Cytotoxicity was either significantly delayed (lewisite) or prevented (sulfur mustard) when cultures were maintained at 25°C. …”
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4por Munro, N B, Talmage, S S, Griffin, G D, Waters, L C, Watson, A P, King, J F, Hauschild, V“…Of all of these compounds, only Lewisite oxide and EA 2192 possess high mammalian toxicity. …”
Publicado 1999
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5“…Lewisite is not known to generate reproductive or teratogenic effects.…”
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6“…No antidote exists for poisoning by the vesicant sulfur mustard (H, HD, HT); effective intervention can only be accomplished by rapid decontamination followed by palliative treatment of symptoms. British anti-Lewisite (BAL) (2,3-dimercapto-1-propanolol) is the antidote of choice for treatment of exposure to Lewisite, another potent vesicant. …”
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7por Surolia, Ranu, Li, Fu Jun, Wang, Zheng, Kashyap, Mahendra, Srivastava, Ritesh Kumar, Traylor, Amie M., Singh, Pooja, Dsouza, Kevin G., Kim, Harrison, Pittet, Jean-Francois, Zmijewski, Jaroslaw W., Agarwal, Anupam, Athar, Mohammad, Ahmad, Aftab, Antony, Veena B.“…A dermal chemical burn by lewisite or PAO resulted in PAD4 activation, NETosis, and ALI. …”
Publicado 2021
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8por Srivastava, Ritesh Kumar, Mishra, Bharat, Muzaffar, Suhail, Gorbatyuk, Marina S., Agarwal, Anupam, Mukhtar, M. Shahid, Athar, Mohammad“…Their accidental exposure (e.g. arsenical lewisite) is also known and causes extensive painful cutaneous injury. …”
Publicado 2022
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9“…This is the basis of the clinical presentation of acute Cartap poisoning as well as the treatment with chelators namely British Anti Lewisite and sodium dimercaptopropane sulfonate.…”
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10por Bjørklund, Geir, Crisponi, Guido, Nurchi, Valeria Marina, Cappai, Rosita, Buha Djordjevic, Aleksandra, Aaseth, Jan“…The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. …”
Publicado 2019
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11por Gupta, Akshay, Amaducci, Alexandra, Koons, Andrew, Lindmark, John D, Beauchamp, Gillian A“…In consultation with Medical Toxicology, the patient was chelated with calcium disodium edetate (EDTA) and British Anti Lewisite (BAL). The patient’s hyponatremia was managed with hypertonic saline infusion. …”
Publicado 2021
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12por Rafati-Rahimzadeh, Mehrdad, Rafati-Rahimzadeh, Mehravar, Kazemi, Sohrab, Moghadamnia, Ali Akbar“…Besides supportive therapy, British anti lewisite, dimercaprol (BAL), 2,3-dimercaptosuccinic acid (DMSA. succimer) and dimercaptopropanesulfoxid acid (DMPS) are currently used as chelating agents in mercury poisoning. …”
Publicado 2014
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13por Menke, Bryant A., Ryu, Christine, Justin, Grant A., Chundury, Rao V., Hayek, Brent R., Debiec, Matthew R., Yeh, Steven“…This mini-review focuses on key chemical agents including vesicants (mustards, lewisite), nerve agents (sarin, VX), knockdown gasses (hydrogen cyanide), and caustics (hydrofluoric acid). …”
Publicado 2023
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14por Mokhtarifar, Ali, Mozaffari, Hooman, Afshari, Reza, Goshayeshi, Ladan, Akavan Rezayat, Kambiz, Ghaffarzadegan, Kamran, Sheikhian, Mohammadreza, Rajabzadeh, Farnood“…Thus, treatment with ethylenediaminetetraacetic acid (EDTA) and British anti-lewisite (BAL) were initiated and continued for five days. …”
Publicado 2013
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15por Crivat, Georgeta, Tokumasu, Fuyuki, Sa, Juliana Martha, Hwang, Jeeseong, Wellems, Thomas E.“…Rigorous treatment with BAL (2, 3 dimercaptopropanol; British anti-Lewisite) was required to reduce high background due to nonspecific BAF interactions with endogenous cysteine-rich proteins. …”
Publicado 2011
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16por Srivastava, Ritesh K., Li, Changzhao, Weng, Zhiping, Agarwal, Anupam, Elmets, Craig A., Afaq, Farrukh, Athar, Mohammad“…These effects are similar to those manifested by lewisite suggesting that PAO could be used as a prototype of arsenicals to define the molecular pathogenesis of chemical injury.…”
Publicado 2016
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17por Muzaffar, Suhail, Khan, Jasim, Srivastava, Ritesh, Gorbatyuk, Marina S., Athar, Mohammad“…Among these CWAs, adamsite, Clark I, Clark II, and lewisite are of critical importance, as stockpiles of these agents still exist worldwide. …”
Publicado 2022
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18por Nobre, Paula, Cabral, Maria de Fátima, Costa, Judite, Castro-Caldas, Margarida, Carvalho, Cristina, Branco, Vasco“…Current clinical approaches to mitigate the toxicity of MeHg rely on the use of chelators, such as meso-2,3-dimercaptosuccinic acid (DMSA) which largely replaced British anti-Lewisite or 2,3-dimercapto-1-propanol (BAL) as the prime choice. …”
Publicado 2019
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