“…Interestingly, the downregulation of RAG2, a gene involved in T-cell differentiation in the thymus, could be simultaneously controlled by the downregulation of two circRNASs (hsa_circ_0031584 and hsa_circ_0019079) through the hypothetical liberation of hsa-miR-609. Our study provides, for the first time, significant insights into the usefulness of circRNAs in discriminating between different stages of thymocyte differentiation and provides new potential circRNA–miRNA–mRNA networks capable of controlling the expression of genes involved in T-cell differentiation in the thymus.…”
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“…As PAPhy activity supplies phosphate, liberates metal ions necessary for seedling emergence, and obviates antinutrient effects of phytate, its manipulation and control are targeted crop traits. …”
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“…Since γ-secretase mediates the final cleavage that liberates Aβ, γ-secretase has been widely studied as a potential drug target for the treatment of AD. γ-Secretase is a transmembrane protein complex containing presenilin, nicastrin, Aph-1, and Pen-2, which are sufficient for γ-secretase activity. γ-Secretase cleaves >140 substrates, including APP and Notch. …”
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“…Therefore, many fluorophore fragments are liberated to produce a significantly amplified fluorescence signal toward CEA detection. …”
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“…Subsequent catalytic cleavage of the DNAzyme by the corresponding metal ions results in recycling of the enzymatic sequences and cyclic cleavage of the substrate strand, liberating many short FAM-linked oligonuleotide fragments separated from the GO surface, which results in fluorescence enhancement due to the weak affinity of the short FAM-linked oligonuleotide fragment to GO. …”
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“…Therefore, KODA production in transgenic plants stably expressing 9-LOX and AOS requires specific sub-cellular localization of these two enzymes and incubation of crude leaf extracts, which liberates α-linolenic acid via breakdown of endogenous lipids.…”
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“…Herein, we describe a novel, H(2)O(2)-responsive DOX hybrid codrug (mutual prodrug) that has been rationally designed to concurrently liberate hydrogen sulfide (H(2)S), a purported cardioprotectant with anticancer activity, in an effort to maintain the antitumor effects of DOX while simultaneously reducing its cardiotoxic side effects. …”
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“…We observed substantial increases in the hazard and incidence of red wolf reported poaching, and smaller increases in disappearances, during periods of reduced federal and state protections (including liberalizing hunting of coyotes, C. latrans); white-tailed deer (Odocoileus virginianus) and American black bear (Ursus americanus) hunting seasons; and management phases. …”
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“…We concluded that heme-induced upregulation of the Nrf2/HO-1 system inhibits HuLECs calcification through the liberation of heme iron.…”
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“…If fuel rods leak, they liberate radionuclides into the cooling water; therefore, it is essential to determine radionuclide concentrations in the pool water for monitoring purposes and to plan the decommissioning process. …”
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“…METHODS: In the present observational cohort study, 61 patients who received VA-ECMO-supported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were enrolled. The endpoint characteristics such as all-cause mortality, repeated cardiovascular diseases, and cardiac death were examined. …”
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“…Meanwhile, the dihydrogen bond (N–H(δ+)···(δ−)H–B) is favorably formed under E(ext), and the interaction between relevant H atoms is enhanced, leading to a faster H(2) liberation. Correspondingly, the apparent activation energy for AB dissociation is greatly reduced from 18.42 to around 15 kcal·mol(–1) with the application of an electric field, while that for H(2) formation decreases from 20.4 to about 16 kcal·mol(–1). …”
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“…The normative foundations of SAGE are communitarianism, classical liberalism, materialistic utilitarianism, and ecoethics. …”
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“…In the food industry, enzymatic hydrolysis is the most common technique employed for the liberation of BPs from proteins in which conventional heat treatment is used as pre-treatment to enhance hydrolytic action. …”
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“…The HV electric-pulse application shows a good possibility of achieving a high energy efficiency with the size reduction and selective liberation of minerals from rocks. The electric and dielectric properties were first measured, and the mineral compositions were also determined by using a micro-X-ray fluorescence spectrometer. …”
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“…Due to their time‐consuming nature, enzymatic methods for liberation of single muscle fibers with fully quiescent MuSCs are challenging. …”
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“…Cleaning products contain numerous individual chemicals, which can be liberated on use. These species can react in air to form new chemical species, some of which are harmful to health. …”
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“…Such a response stimulates macrophage activation, leads to the activation of NOD-like receptor protein 3 (NLRP3) inflammasome vesicles, and ultimately the production and liberation of interleukin-1b (IL-1b) and interleukin-18 (IL-18), which can mediate inflammation, apoptosis and necroinflammation and cause an inflammatory cascade response. …”
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“…Besides increasing energy expenditure, exercise induces the synthesis and liberation of several muscle-derived myokines and neuroendocrine peptides such as neuropeptide Y, peptide YY, ghrelin, and leptin, which act directly on the gut-microbiota-brain axis. …”
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“…The approach of using a very basic paint system, based on a polymer binder embedded with “smart release” pigment containing an anti-viral agent which is liberated by ion-exchange, holds significant promise as a cost effective and rapidly deployed coating to confer virus inactivating capability to high touch surfaces.…”
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