“…Phosphomutation of a conserved LIC1-CTD SP site in zebrafish leads to early developmental defects. …”
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“…In the crystal, both mol­ecules form R (2) (2)(6) carb­oxy­lic acid inversion dimers via pairs of O—H⋯O hydrogen bonds. …”
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“…In the crystal structure of the title mol­ecular adduct, C(9)H(7)N·C(8)H(12)O(4), the two species are ­linked through a carb­oxy­lic acid–isoquinoline O—H⋯N hydrogen bond. These mol­ecular pairs then inter-associate through the second acid group of the cis-cyclo­hexane-1,2-dicarb­oxy­lic acid molecules, forming a classic centrosymmetric cyclic head-to-head carb­oxy­lic acid–carboxyl O—H⋯O hydrogen-bonding association [graph-set R (2) (2)(8)], giving a zero-dimensional (cluster) structure, consisting of two of each species.…”
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“…A three-dimensional structure is formed through N—H⋯O and O—H⋯O hydrogen bonds between the amide and carb­oxy­lic acid groups and both carb­oxy­lic acid and amide O-atom acceptors.…”
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“…In the title compound, C(12)H(11)NO(4), the dihedral angle between the benzene and isoxazole rings is 42.52 (8)°. The carb­oxy­lic acid group is close to being coplanar with the isoxazole ring [dihedral angle = 5.3 (2)°]. …”
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“…The cyclo­hexane ring exhibits a chair conformation with the carb­oxy­lic acid groups in equatorial and axial orientations. …”
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“…The 2.35 Å resolution crystal structure provides insights into the active site geometry and substrate specificity, and unveiled an unusual calcium-independent maturation mechanism of a subtilisin family member. LicP processes LicA2 peptides with or without post-translational modifications, but dehydrated and cyclized LicA2 is favored. …”
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“…We propose that a tunable LIC1-adaptor interaction modulates dynein’s motility in a cargo-specific manner.…”
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“…The asymmetric unit of the title compound, C(12)H(8)O(4)·2C(5)H(9)NO, contains one half-mol­ecule of naphthalene-2,6-dicarb­oxy­lic acid (NDA) and one mol­ecule of 1-methyl­pyrrolidin-2-one (NMP): the NDA molecules lie on the crystallographic twofold rotation axes. …”
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“…Self-assembly of these dimeric units results in a four-component supra­molecular unit featuring a homosynthon between two mol­ecules of the pyrimidin-2-amine involving two N—H⋯O hydrogen bonds, and two heterosynthons between each one mol­ecule of pyrimidin-2-amine and 1-phenyl­cyclo­pentane-1-carb­oxy­lic acid involving N—H⋯O and O—H⋯N hydrogen bonds.…”
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“…To our knowledge, pBLIC is the first LIC vector for retroviral transduction-mediated stable gene expression in mammalian cells.…”
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“…In the title compound, C(14)H(9)FN(2)O(2)S, the thieno[2,3-b]pyridine residue is almost planar (r.m.s. deviation = 0.0194 Å), with the carb­oxy­lic acid group [dihedral angle = 11.9 (3)°] and the benzene ring [71.1 (4)°] being twisted out of this plane to different extents. …”
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“…The asymmetric unit of the title compound, C(9)H(6)O(6)·3C(5)H(5)NO, contains one benzene-1,3,5-tri­carb­oxy­lic acid mol­ecule (BTA) and three pyridin-2-ol mol­ecules each present in the zwitterion form. …”
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