Materias dentro de su búsqueda.
Mostrando 221 - 240 Resultados de 152,825 Para Buscar '"Lin An"', tiempo de consulta: 1.00s Limitar resultados
  1. 221
    “…Organochlorine insecticide hexachlorocyclohexane (HCH) has recently been classified as a ‘Persistent Organic pollutant’ by the Stockholm Convention. The LinB haloalkane dehalogenase is a key upstream enzyme in the recently evolved Lin pathway for the catabolism of HCH in bacteria. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Kinetic and Sequence-Structure-Function Analysis of LinB Enzyme Variants with β- and δ-Hexachlorocyclohexane
  2. 222
    “…The pluripotency factor Lin28 inhibits the biogenesis of the let-7 family of mammalian microRNAs(1–4). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
  3. 223
    “…Colorectal cancer (CRC) remains a major contributor to cancer-related mortality. LIN28A and LIN28B are highly related RNA-binding protein paralogs that regulate biogenesis of let-7 microRNAs and influence development, metabolism, tissue regeneration, and oncogenesis. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans
  4. 224
    “…Through RNA pull-downs coupled with quantitative mass spectrometry, we identified the E3 ligase Trim25 as an RNA-specific cofactor for Lin28a/TuT4-mediated uridylation. We show that Trim25 binds to the conserved terminal loop (CTL) of pre-let-7 and activates TuT4, allowing for more efficient Lin28a-mediated uridylation. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation
  5. 225
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Murine Sca1(+)Lin(−) bone marrow contains an endodermal precursor population that differentiates into hepatocytes
  6. 226
    “…RESULTS: Over-expression of Lin28A resulted in key changes to cellular metabolism not observed in wild-type controls. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells
  7. 227
    “…Previous genome‐wide association study indicated that lin‐28 homolog B (LIN28B) might play an important role in the development of neuroblastoma and also contributed to its poor overall survival. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children
  8. 228
    “…Thus, differential regulation of the c-Myc/Lin28/let-7g program by different MLL-FPs is functionally related to disease latency and BET inhibitor resistance in MLL leukemias.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia
  9. 229
    “…Taken together, these data demonstrate a positive role of PpCSP1 in reprogramming, which is similar to the function of mammalian Lin28.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens
  10. 230
    “…We also demonstrate that the LIN28B/let-7 axis modulates the expression of MYC, itself a let-7 target. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma
  11. 231
    “…LinA-type1 and LinA-type2 are two well-characterized variants of the enzyme ‘hexachlorocyclohexane (HCH)-dehydrochlorinase’. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Important amino acid residues of hexachlorocyclohexane dehydrochlorinases (LinA) for enantioselective transformation of hexachlorocyclohexane isomers
  12. 232
    “…IGF2BP1 was confirmed to be a novel downstream target of LIN28B via let-7 miRNA in AML. Notably, ectopic expression of LIN28B increased tumorigenicity, while silencing LIN28B led to slow tumor growth in vivo. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia
  13. 233
    por Amon, Siavash, Gupta, Bhagwati P.
    Publicado 2017
    “…This data article contains multi-species alignments of the regulatory region of C. elegans LIM-HOX gene lin-11 and lists of transcription factors that are predicted to bind to lin-11 enhancers and regulate expression in amphid neurons. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Multi-species alignments of C. elegans lin-11 intronic sequences and putative transcriptional regulators
  14. 234
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Lin(−)CCR2(+) hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
  15. 235
    por Xu, Chaoyang, Jin, Shuxun, Huang, Liming
    Publicado 2019
    “…OBJECTIVE: Cumulative data from clinical trials suggest that Lin28 may contribute to poor survival in breast cancer patients. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Expression of Lin28 is correlated with prognosis and expression of HER-2 and steroid receptors in breast cancer
  16. 236
    “…Importantly, maintained expression of Lin28 prolongs hub integrity and function in aged testes, suggesting that Lin28 decline is a driver of hub cell aging. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche
  17. 237
    “…Interestingly, pluripotent cell factor RNA‐binding protein Lin28 enhances TNFR2 protein expression in early CSC activation by directly binding to a conserved Lin28‐motif within the 3'UTR of Tnfr2 mRNA. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Critical role of Lin28‐TNFR2 signalling in cardiac stem cell activation and differentiation
  18. 238
    “…Genome-wide association studies (GWAS) have recurrently associated sequence variation nearby LIN28B with pubertal timing, growth and disease. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    LIN28B affects gene expression at the hypothalamic-pituitary axis and serum testosterone levels
  19. 239
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Accumulation of Anthocyanins through Overexpression of AtPAP1 in Solanum nigrum Lin. (Black Nightshade)
  20. 240
    “…An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28
Herramientas de búsqueda: RSS