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Mostrando 261 - 280 Resultados de 152,825 Para Buscar '"Lin An"', tiempo de consulta: 0.83s Limitar resultados
  1. 261
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    P332: LIN28B: AN IMPORTANT ONCO-FETAL GENE IN INFANT ACUTE LYMPHOBLASTIC LEUKAEMIA
  2. 262
    “…CASK, the rat homolog of a gene (LIN-2) required for vulval differentiation in Caenorhabditis elegans, is expressed in mammalian brain, but its function in neurons is unknown. …”
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    Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses
  3. 263
    “…Lin28 and Lin28B, two developmentally regulated RNA-binding proteins and proto-oncogenes, selectively inhibit the maturation of let-7 family miRNAs in embryonic stem (ES) cells and certain cancers. …”
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    Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells
  4. 264
    “…Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs. …”
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    Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells
  5. 265
    “…BACKGROUND: LIN-12/Notch signaling is important for cell-cell interactions during development, and mutations resulting in constitutive LIN-12/Notch signaling can cause cancer. …”
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    sel-11 and cdc-42, Two Negative Modulators of LIN-12/Notch Activity in C. elegans
  6. 266
    “…For this purpose it is necessary to take full advantage of the quantification levels provided by the CCD/CMOS image sensor. LinLog CMOS sensors satisfy the above demand by offering an adjustable response curve that combines linear and logarithmic responses. …”
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    A Novel Method to Increase LinLog CMOS Sensors’ Performance in High Dynamic Range Scenarios
  7. 267
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    Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer
  8. 268
    “…The EGFP silencing was comparable with LinOS and with DOS when mixed with cholesterol 1:2 (lipoplexes prepared with 15 pmol of siRNA), but LinOS mixtures showed better EGFP silencing when the siRNA was reduced to 3.75 pmol. …”
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    Quantitative Silencing of EGFP Reporter Gene by Self-Assembled siRNA Lipoplexes of LinOS and Cholesterol
  9. 269
    “…Using an LIN28A specific antibody, we carried out immunohistochemical analysis of LIN28A in more than 800 childhood brain-tumor samples and confirmed its high specificity for ETMR. …”
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    LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
  10. 270
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    The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function
  11. 271
    por Mayr, Florian, Heinemann, Udo
    Publicado 2013
    “…Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem cells. …”
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    Mechanisms of Lin28-Mediated miRNA and mRNA Regulation—A Structural and Functional Perspective
  12. 272
    por Luz, Marta, Knust, Elisabeth
    Publicado 2013
    “…This apical Lin7c localization depends on the Crb complex members Oko meduzy and Nagie oko. …”
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    Fluorescently tagged Lin7c is a dynamic marker for polarity maturation in the zebrafish retinal epithelium
  13. 273
    “…Recent studies showed that incomplete cell reprogramming can transform cells into tumour-like cells. Lin28A is associated with fibroblast and sarcoma cell reprogramming, whereas its homologue Lin28B is associated with hematopoietic cell reprogramming. …”
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    Increased Expression of Lin28B Associates with Poor Prognosis in Patients with Oral Squamous Cell Carcinoma
  14. 274
    “…Lin28 inhibits the biogenesis of let-7 miRNAs through direct interactions with let-7 precursors. …”
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    Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors
  15. 275
    “…LIN28 has emerged as an oncogenic driver in a number of cancers, including neuroblastoma (NB). …”
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    Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
  16. 276
    “…Lin41/Trim71 is a heterochronic gene encoding a member of the Trim-NHL protein family, and is the original, genetically defined target of the microRNA let-7 in C. elegans. …”
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    Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain
  17. 277
    “…Mouse B cell precursors from fetal liver and adult bone marrow (BM) generate distinctive B cell progeny when transplanted into immunodeficient recipients, supporting a two-pathway model for B lymphopoiesis, fetal “B-1” and adult “B-2.” Recently, Lin28b was shown to be important for the switch between fetal and adult pathways; however, neither the mechanism of Lin28b action nor the importance of B cell antigen receptor (BCR) signaling in this process was addressed. …”
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    Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a
  18. 278
    “…We found that the Wnt ligand, lin-44, was SynLet with sdn-1, but not ptp-3. We used 4-dimensional time-lapse analysis to characterize the interaction between lin-44 and sdn-1. …”
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    A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis
  19. 279
    “…The precise control of microRNA (miRNA) biosynthesis is crucial for gene regulation. Lin28A and Lin28B are selective inhibitors of biogenesis of let-7 miRNAs involved in development and tumorigenesis. …”
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    A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B
  20. 280
    “…Progenies of transplanted Lin(−) cells showed similar kinetics of expansion and myeloid differentiation in BM. …”
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    Alleviation of skin inflammation after Lin(−) cell transplantation correlates with their differentiation into myeloid-derived suppressor cells
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