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Mostrando 281 - 300 Resultados de 152,825 Para Buscar '"Lin An"', tiempo de consulta: 1.39s Limitar resultados
  1. 281
    “…OBJECTIVE: LIN28B is a conserved RNA-binding protein critically involved in development, cellular metabolism and tumorigenesis. …”
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    The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis
  2. 282
    “…Background: Lin28 proteins are post‐transcriptional regulators of gene expression with multiple roles in development and the regulation of pluripotency in stem cells. …”
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    lin28 proteins promote expression of 17∼92 family miRNAs during amphibian development
  3. 283
    “…This decrease in Lin28b coincides with accumulation of mature let-7 microRNAs, whose biogenesis is regulated by Lin28 proteins. …”
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    Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
  4. 284
    “…The pipeline software is available open source at https://github.com/cfce/chilin. CONCLUSION: ChiLin is a scalable and powerful tool to process large batches of ChIP-seq and DNase-seq datasets. …”
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    ChiLin: a comprehensive ChIP-seq and DNase-seq quality control and analysis pipeline
  5. 285
    “…Four distinct in vivo phosphorylated LIN-5 residues were found to have critical functions in spindle positioning. …”
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    Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans
  6. 286
    “…It demonstrated that down-regulation of the RNA binding protein Lin28B was one of the key factors leading to the overexpression of let-7e and let-7i. …”
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    Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas
  7. 287
    “…The protein Lin28 and microRNA let-7 play critical roles in mammalian development and human disease. …”
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    Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
  8. 288
    “…The same was observed for LIN9 and Bax (P<0.05). By contrast, Bcl-2 was downregulated in LV-hTRM9L (P<0.05). …”
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    Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9
  9. 289
    “…The Lin28/let-7 axis plays an important role in tumor initiation and developmental processes. …”
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    Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells
  10. 290
    “…The latter appears to be an indirect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a synMuvB class transcription factor known to antagonize PRC2 activity. …”
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    Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B
  11. 291
    “…AIM: To examine whether nuclear factor kappa B (NF-κB) activity regulates LIN28B expression and their roles in leukemia stem cell (LSC)-like properties. …”
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    NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B
  12. 292
    “…Mutation of met-2 or lin-65 also disrupts the perinuclear anchoring of genomic heterochromatin. …”
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    Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65
  13. 293
    “…The RNA-binding protein LIN28 is known to regulate cell fate, tissue growth, and pluripotency; however, a unified understanding of its role at the cellular level has not been achieved. …”
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    The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis
  14. 294
    “…The interaction between the Lin28:pre-let-7 complex and the N-terminal Lin28-interacting module (LIM) of TUT4/7 is required for pre-let-7 oligo-uridylylation by the C-terminal catalytic module (CM) of TUT4/7. …”
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    Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
  15. 295
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    Modulation of dopamine metabolizing enzymes and antioxidant status by Capsicum annuum Lin in rotenone-intoxicated rat brain
  16. 296
    “…While mutants for other NuRD members show a normal lifespan, animals lacking LIN‐53 die early because LIN‐53 depletion affects also the histone deacetylase complex Sin3, which is required for a normal lifespan. …”
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    The conserved histone chaperone LIN‐53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans
  17. 297
    “…In this study, we found that overexpression of Lin28B significantly increased the paclitaxel chemoresistance in two different HCC cells lines while silencing Lin28B reduced the chemoresistance in paclitaxel-resistance HCC cells. …”
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    Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma
  18. 298
    “…Furthermore, we show that BCL11A mRNA translation is suppressed by LIN28B through direct interactions, independent of its role in regulating let-7 microRNAs, and BCL11A is the major target of LIN28B-mediated HbF induction. …”
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    Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation
  19. 299
    “…We demonstrate that unique isoform expression patterns are generated by the activities of LIN-41 for lin-29a, and of HBL-1 for lin-29b, whereas the RNA-binding protein LIN-28 coordinates LIN-29 isoform activity, in part by regulating both hbl-1 and lin-41. …”
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    A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms
  20. 300
    “…Tissue microarrays were constructed from archival paraffin blocks and assessed for AR and its regulatory molecule, Lin28, by immunohistochemistry. The association between AR and Lin28 expression and clinicopathological parameters was analyzed. …”
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    Expression of androgen receptor and its regulatory molecule Lin28 in non-luminal subtype breast cancer
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