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Mostrando 321 - 340 Resultados de 152,825 Para Buscar '"Lin An"', tiempo de consulta: 0.75s Limitar resultados
  1. 321
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    cis-9,10-Bis(bromo­meth­yl)-1,4,5,8-tetra­oxadeca­lin
  2. 322
    “…Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-5]. …”
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    Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies
  3. 323
    “…We further show that LIN-28 binds endogenous primary let-7 transcripts in the nuclear compartment of human ES cells, suggesting that this LIN-28 activity is conserved across species. …”
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    LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans
  4. 324
    “…The pluripotency factor Lin28 is a highly conserved protein comprising a unique combination of RNA-binding motifs, an N-terminal cold-shock domain and a C-terminal region containing two retroviral-type CCHC zinc-binding domains. …”
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    Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28
  5. 325
    “…Lin28 proteins are emerging as important regulators of microRNAs in endocrine systems. …”
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    Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency
  6. 326
    “…Expression of LIN28B and let-7 miRNA correlated with rs17065417 genotype in neuroblastoma cell lines, and we observed significant growth inhibition upon depletion of LIN28B specifically in neuroblastoma cells homozygous for the risk allele. …”
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    Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
  7. 327
    “…In this study we examined the effect of knocking down LIN9 on ESCs. We demonstrate that depletion of LIN9 alters the cell cycle distribution of ESCs and results in an accumulation of cells in G2 and M and in an increase of polyploid cells. …”
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    LIN9, a Subunit of the DREAM Complex, Regulates Mitotic Gene Expression and Proliferation of Embryonic Stem Cells
  8. 328
    “…The pluripotency factor Lin28 blocks the expression of let-7 microRNAs (miRNAs) in undifferentiated cells during development and functions as an oncogene in a subset of cancers(1). …”
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    A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
  9. 329
    “…However, the predictive value of LIN28 in HCC outcome is still undetermined. We hypothesized that LIN28 may also play a role as a biomarker for HCC. …”
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    LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy
  10. 330
    “…By using an expressed sequence tag bioinformatic algorithm, we identified that Lin28 homolog B (Lin28B) may have an oncofetal expression pattern which may facilitate detecting cancer cells in adults. …”
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    Lin28B Is an Oncofetal Circulating Cancer Stem Cell-Like Marker Associated with Recurrence of Hepatocellular Carcinoma
  11. 331
    “…Mobilization of Lin−/Sca1+ cells to blood was significantly elevated at 24 hrs (607±159%; P<0.05). …”
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    SDF1-A Facilitates Lin−/Sca1+ Cell Homing following Murine Experimental Cerebral Ischemia
  12. 332
    “…We reported previously that down-regulation of Lin-7C is essential for metastasis of human squamous cell carcinomas (hSCCs). …”
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    Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells
  13. 333
    “…Using fluorescence activated cell sorting (FACS), we identified a Sca-1(+)/ CD34(+)/ lin(-) (PECAM(-): CD45(-): Ter119(-)) population in the adult murine bladder. …”
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    The Murine Bladder Supports a Population of Stromal Sca-1(+)/CD34(+)/lin(-) Mesenchymal Stem Cells
  14. 334
    por El-Say, Khalid Mohamed
    Publicado 2016
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    Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper–Lin small composite design
  15. 335
    “…Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3′-5′ exoribonuclease Dis3l2, respectively. …”
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    Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively
  16. 336
    “…TRIM71 overexpression opposed Lin28B-induced transformation in primary cells and inhibited tumor formation in a mouse model. …”
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    TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling
  17. 337
    “…Lin-28 homolog B (Lin28B) is a RNA binding protein conserved between Caenorhabditis elegans and humans, and it has important roles in regulating development. …”
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    Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner
  18. 338
    “…Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. …”
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    The LIN28B–IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine
  19. 339
    “…Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA-binding protein, which serves a fundamental role in cell development and pluripotency. …”
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    High LIN28A and PLK4 co-expression is associated with poor prognosis in epithelial ovarian cancer
  20. 340
    “…Deletion of adpA(lin) (which generated ΔadpA(lin)) interrupted lincomycin biosynthesis and impaired the morphological differentiation. …”
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    AdpA(lin), a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis
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