“…BACKGROUND: Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results of functional analyses revealed that overexpression of miR-501-3p in HCCLM3 cancer cells inhibited their proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT), while miR-501-3p loss in PLC/PRF/5 cancer cells facilitated all these cellular activities. In addition, Lin-7 homolog A (LIN7A) was directly targeted by miR-501-3p to mediate the suppression effects on metastasis in HCC cells. miR-501-3p suppresses metastasis and progression of HCCs through targeting LIN7A. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The study comprises a cross-sectional population-based prospective cohort of pregnant women (Little in Norway (LiN)). Median UIC in 954 urine samples was 85 µg/L and 78.4% of the samples (n = 748) were ≤150 µg/L. 23.2% (n = 221) of the samples were ≤50 µg/L and 5.2% (n = 50) were above the requirements of iodine intake (>250 µg/L). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To our knowledge, the evaluation of Lin- cells transplantation for ALS treatment has not been previously reported. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Exploiting our laboratory’s click chemistry-based high-throughput screening (HTS) technology, catalytic enzyme-linked click chemistry assay or cat-ELCCA, we have designed a modular method by which to discover new chemical tools for manipulating pre-miRNA–miRNA–binding protein interactions. Using the pre-let-7d–Lin28 interaction as proof-of-concept, the results presented demonstrate how HTS using cat-ELCCA can enable the discovery of small molecules targeting RNA–protein interactions.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we report a fluorescence polarization assay to identify small-molecule inhibitors for both domains of LIN28 involved in let-7 interactions. Of 101,017 compounds screened, six inhibit LIN28:let-7 binding and impair LIN28-mediated let-7 oligouridylation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we genotyped four LIN28A polymorphisms in 355 Wilms tumour patients and 1070 healthy controls from four hospitals in China. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The LIN28:pre-let-7:TUTase ternary complex regulates pluripotency and oncogenesis by controlling processing of the let-7 family of microRNAs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…LIN28 inhibits let-7 miRNA maturation which prevents cell differentiation and promotes proliferation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Oppositely, overexpression of CAIX leads to the enhancement of LIN28, ALDH1, and NANOG. In conclusion, CAIX-driven regulation of the LIN28/let-7 axis augments glycolytic metabolism and enhances stem cell markers expression during CAIX-mediated adaptation to hypoxia and acidosis in carcinogenesis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Concentrated electrolytes usually demonstrate good electrochemical performance and thermal stability, and are also supposed to be promising when it comes to improving the safety of lithium-ion batteries due to their low flammability. Here, we show that LiN(SO(2)F)(2)-based concentrated electrolytes are incapable of solving the safety issues of lithium-ion batteries. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using real-time PCR and Western blot analysis, expression levels of Lin28b or miRNAs were investigated in response to the overexpression of Fhit gene in H1299 lung cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A negative correlation between LIN28B and miR-152-3p was observed in ESC. In addition, overexpression of miR-152-3p suppressed the progression of ESC by directly targeting and regulating LIN28B. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using a sample of 1,325 large-scale farming households in Lin’an, this study constructs a theoretical path for how the level of vertical integration and an organization model affect farmers’ income levels and empirically tests the path using a mediation effect analysis model. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…LIN37 is not required to protect DNA ends in cycling cells at G(1)-phase. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Reintroduction of LIN28a in adult CTSC (CTSC-LIN) increased proliferation, survival, expression of pluripotency genes and reduced senescence compared to control (CTSC-GFP). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: LINS1 encodes the lines homolog 1 protein that contains the Drosophila lines homologous domain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The RNA-binding protein LIN28B is an important factor for cell proliferation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Lin28a is an RNA-binding protein involved in the translation and regulation of multiple mRNAs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso