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  1. 161
    por Valencia, Édgar, Zottele, Esteban
    Publicado 2021
    Materias: “…Lin Yi An…”
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    La traducción de las diez mil cosas. Entrevista con Lin Yi An
  2. 162
    “…LIN-35 is the sole C. elegans representative of the pocket protein family, which includes the mammalian Retinoblastoma protein pRb and its paralogs p107 and p130. …”
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    Coordinated Regulation of Intestinal Functions in C. elegans by LIN-35/Rb and SLR-2
  3. 163
    “…We further show that Blimp1, a let-7 target and a master regulator of PGC specification7-9, can rescue the effect of Lin28-deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. …”
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    A role for Lin28 in primordial germ cell development and germ cell malignancy
  4. 164
    “…lin-28 is a conserved regulator of cell fate succession in animals. …”
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    lin-28 Controls the Succession of Cell Fate Choices via Two Distinct Activities
  5. 165
    “…In this study, we describe characterization of a novel variant (LinA-type2) that is distinct from reported LinAs and is substantially more thermostable than archetypal LinA-UT26. …”
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    Isolation of a novel thermostable dehydrochlorinase (LinA) from a soil metagenome
  6. 166
    “…The RNA-binding protein Lin28 regulates the processing of a developmentally important group of microRNAs, the let-7 family. …”
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    The Lin28 cold-shock domain remodels pre-let-7 microRNA
  7. 167
    “…PURPOSE: Single-nucleotide polymorphism (SNP) markers within LIN28B have been reported to be related to the timing of pubertal growth. …”
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    LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls
  8. 168
    “…The RNA-binding proteins LIN28A and LIN28B have diverse functions in embryonic stem cells, cellular reprogramming, growth, and oncogenesis. …”
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    LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
  9. 169
    “…Embryonic expression of LIN28B mRNA was higher in early stages (≤6-weeks) of ectopic pregnancy than in normal gestation. …”
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    The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy
  10. 170
    “…Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. …”
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    Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development
  11. 171
    “…Finally, using an inducible system we demonstrate that Lin28a can also reduce miR-9 levels in differentiated P19 cells. …”
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    Lin28a regulates neuronal differentiation and controls miR-9 production
  12. 172
    “…Analysis of mature miRNA levels in lin-42 mutants indicates that lin-42 functions to attenuate miRNA expression. …”
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    LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription
  13. 173
    “…We found that LIN-41 is expressed in the cytoplasm of developing oocytes, which, in lin-41 mutants, acquire pluripotent characteristics of embryonic cells and form teratomas. …”
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    The TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans
  14. 174
    por Shi, Fei, Yu, Wenbao, Wang, Xia
    Publicado 2014
    “…To explore the physiological significance of let-7 in regulating cell fate decisions, we present a coarse grained model of let-7 biogenesis network, in which let-7 and its regulator Lin28 inhibit mutually. The dynamics of this minimal network architecture indicates that, as the concentration of Lin28 increases, the system undergoes a transition from monostability to a bistability and then to a one-way switch with increasing strength of positive feedback of let-7, while in the absence of Lin28 inhibition, the system loses bistability. …”
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    Bistable Switch in let-7 miRNA Biogenesis Pathway Involving Lin28
  15. 175
    “…Two haloalkane dehalogenases, LinB(UT) and LinB(MI), each with 296 amino acid residues, exhibit only seven amino acid residue differences between them, but LinB(MI)’s catalytic performance towards β-hexachlorocyclohexane (β-HCH) is considerably higher than LinB(UT)’s. …”
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    Stepwise enhancement of catalytic performance of haloalkane dehalogenase LinB towards β-hexachlorocyclohexane
  16. 176
    “…CONCLUSION: This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis. …”
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    LIN7A is a major determinant of cell-polarity defects in breast carcinomas
  17. 177
    “…MuvB contains the DNA-binding protein LIN54, which directs the complex to promoter cell cycle genes homology region (CHR) elements. …”
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    Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters
  18. 178
    “…LIN28 phosphorylation had little impact on let-7 but enhanced LIN28’s effect on its direct mRNA targets, revealing a mechanism that uncouples LIN28’s let-7-dependent and independent activities. …”
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    LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency
  19. 179
    “…We found a strong correlation among positive serology to recombinant proteins LinB-13, 26, 15, 21 and to salivary proteins: rLinB-13 was the top performing molecule; IgG4 was the most predominant antibody subclass and antibodies to rLinB-13 did not cross react with Lu. longipalpis salivary proteins. …”
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    Seroconversion to Lutzomyia intermedia LinB-13 as a biomarker for developing cutaneous leishmaniasis
  20. 180
    “…The Lin28a/Let-7 axis has been studied in peripheral tissues for its role in metabolism regulation. …”
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    Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
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