Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

por Ziff, Oliver J., Neeves, Jacob, Mitchell, Jamie, Tyzack, Giulia, Martinez-Ruiz, Carlos, Luisier, Raphaelle, Chakrabarti, Anob M., McGranahan, Nicholas, Litchfield, Kevin, Boulton, Simon J., Al-Chalabi, Ammar, Kelly, Gavin, Humphrey, Jack, Patani, Rickie
Publicado 2023

Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein

por Nouri-Nejad, Daniel, O’Donnell, Brooke L., Patil, Chetan S., Sanchez-Pupo, Rafael E., Johnston, Danielle, Sayedyahossein, Samar, Jurcic, Kristina, Lau, Rebecca, Gyenis, Laszlo, Litchfield, David W., Jackson, Michael F., Gloor, Gregory B., Penuela, Silvia
Publicado 2021

Identification of four new susceptibility loci for testicular germ cell tumour

por Litchfield, Kevin, Holroyd, Amy, Lloyd, Amy, Broderick, Peter, Nsengimana, Jérémie, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Bishop, D. Timothy, Reid, Alison, Huddart, Robert A., Grotmol, Tom, Wiklund, Fredrik, Shipley, Janet, Houlston, Richard S., Turnbull, Clare
Publicado 2015

Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer

por Di Pilato, Mauro, Gao, Yun, Sun, Yi, Fu, Amina, Grass, Carina, Seeholzer, Thomas, Feederle, Regina, Mazo, Irina, Kazer, Samuel W., Litchfield, Kevin, von Andrian, Ulrich H., Mempel, Thorsten R., Jenkins, Russell W., Krappmann, Daniel, Keller, Peter
Publicado 2023

Increasing the bulk of the 1TEL–target linker and retaining the 10×His tag in a 1TEL–CMG2-vWa construct improves crystal order and diffraction limits

por Gajjar, Parag L., Pedroza Romo, Maria J., Litchfield, Celeste M., Callahan, Miles, Redd, Nathan, Nawarathnage, Supeshala, Soleimani, Sara, Averett, Jacob, Wilson, Elijah, Lewis, Andrew, Stewart, Cameron, Tseng, Yi-Jie, Doukov, Tzanko, Lebedev, Andrey, Moody, James D.
Publicado 2023

Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

por Litchfield, Kevin, Levy, Max, Dudakia, Darshna, Proszek, Paula, Shipley, Claire, Basten, Sander, Rapley, Elizabeth, Bishop, D. Timothy, Reid, Alison, Huddart, Robert, Broderick, Peter, Castro, David Gonzalez de, O'Connor, Simon, Giles, Rachel H., Houlston, Richard S., Turnbull, Clare
Publicado 2016

Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study

por Zivanovic Bujak, Andjelija, Weng, Chen-Fang, Silva, Maria João, Yeung, Miriam, Lo, Louisa, Ftouni, Sarah, Litchfield, Cassandra, Ko, Yi-An, Kuykhoven, Keilly, Van Geelen, Courtney, Chandrashekar, Sushma, Dawson, Mark A., Loi, Sherene, Wong, Stephen Q., Dawson, Sarah-Jane
Publicado 2020

Capabilities and limitations of different types of detectors: for proton decay

por Grant, A, Bartelt, J, Beier, E W, Chen, H, Cobb, J H, Doe, P, Grant, A, Heagy, S M, Litchfield, P J, Oddone, P, Perkins, Donald Hill, Price, L E, Price, M, Saitta, B, Steinberg, R, Sulak, Lawrence R
Publicado 1982

Trends in diabetes medication use in Australia, Canada, England, and Scotland: a repeated cross-sectional analysis in primary care

por Greiver, Michelle, Havard, Alys, Bowles, Juliana KF, Kalia, Sumeet, Chen, Tao, Aliarzadeh, Babak, Moineddin, Rahim, Sherlock, Julian, Hinton, William, Sullivan, Frank, O’Neill, Braden, Pow, Conrad, Bhatt, Aashka, Rahman, Fahurrozi, Meza-Torres, Bernardo, Litchfield, Melisa, de Lusignan, Simon
Publicado 2021

Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases

por Yngvadottir, Bryndis, Andreou, Avgi, Bassaganyas, Laia, Larionov, Alexey, Cornish, Alex J, Chubb, Daniel, Saunders, Charlie N, Smith, Philip S, Zhang, Huairen, Cole, Yasemin, Research Consortium, Genomics England, Larkin, James, Browning, Lisa, Turajlic, Samra, Litchfield, Kevin, Houlston, Richard S, Maher, Eamonn R
Publicado 2022

Identification and Characterization of Nucleolin as a COUP-TFII Coactivator of Retinoic Acid Receptor β Transcription in Breast Cancer Cells

por Litchfield, Lacey M., Riggs, Krista A., Hockenberry, Alyson M., Oliver, Laura D., Barnhart, Katelyn G., Cai, Jian, Pierce, William M., Ivanova, Margarita M., Bates, Paula J., Appana, Savitri N., Datta, Susmita, Kulesza, Piotr, McBryan, Jean, Young, Leonie S., Klinge, Carolyn M.
Publicado 2012

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

por Gandin, Valentina, Masvidal, Laia, Cargnello, Marie, Gyenis, Laszlo, McLaughlan, Shannon, Cai, Yutian, Tenkerian, Clara, Morita, Masahiro, Balanathan, Preetika, Jean-Jean, Olivier, Stambolic, Vuk, Trost, Matthias, Furic, Luc, Larose, Louise, Koromilas, Antonis E., Asano, Katsura, Litchfield, David, Larsson, Ola, Topisirovic, Ivan
Publicado 2016

Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer

por Loveday, Chey, Litchfield, Kevin, Levy, Max, Holroyd, Amy, Broderick, Peter, Kote-Jarai, Zsofia, Dunning, Alison M, Muir, Kenneth, Peto, Julian, Eeles, Rosalind, Easton, Douglas F, Dudakia, Darshna, Orr, Nick, Pashayan, Nora, Reid, Alison, Huddart, Robert A, Houlston, Richard S, Turnbull, Clare
Publicado 2017

Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells

por Litchfield, Lacey M., Boehnke, Karsten, Brahmachary, Manisha, Mur, Cecilia, Bi, Chen, Stephens, Jennifer R., Sauder, J. Michael, Gutiérrez, Sonia M., McNulty, Ann M., Ye, Xiang S., Wu, Wenjuan, Lallena, María José, Gong, Xueqian, Merzoug, Farhana F., Jansen, Valerie M., Buchanan, Sean G.
Publicado 2020

Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics

por Gyenis, Laszlo, Menyhart, Daniel, Cruise, Edward S., Jurcic, Kristina, Roffey, Scott E., Chai, Darren B., Trifoi, Flaviu, Fess, Sam R., Desormeaux, Paul J., Núñez de Villavicencio Díaz, Teresa, Rabalski, Adam J., Zukowski, Stephanie A., Turowec, Jacob P., Pittock, Paula, Lajoie, Gilles, Litchfield, David W.
Publicado 2022

Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss

por Mejía-Hernández, Javier Octavio, Keam, Simon P., Saleh, Reem, Muntz, Fenella, Fox, Stephen B., Byrne, David, Kogan, Arielle, Pang, Lokman, Huynh, Jennifer, Litchfield, Cassandra, Caramia, Franco, Lozano, Guillermina, He, Hua, You, James M., Sandhu, Shahneen, Williams, Scott G., Haupt, Ygal, Haupt, Sue
Publicado 2022

Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

por Litchfield, Kevin, Reading, James L., Lim, Emilia L., Xu, Hang, Liu, Po, Al-Bakir, Maise, Wong, Yien Ning Sophia, Rowan, Andrew, Funt, Samuel A., Merghoub, Taha, Perkins, David, Lauss, Martin, Svane, Inge Marie, Jönsson, Göran, Herrero, Javier, Larkin, James, Quezada, Sergio A., Hellmann, Matthew D., Turajlic, Samra, Swanton, Charles
Publicado 2020

A Patient Safety Toolkit for Family Practices

por Campbell, Stephen M., Bell, Brian G., Marsden, Kate, Spencer, Rachel, Kadam, Umesh, Perryman, Katherine, Rodgers, Sarah, Litchfield, Ian, Reeves, David, Chuter, Antony, Doos, Lucy, Ricci-Cabello, Ignacio, Gill, Paramjit, Esmail, Aneez, Greenfield, Sheila, Slight, Sarah, Middleton, Karen, Barnett, Jane, Moore, Michael, Valderas, Jose M., Sheikh, Aziz, Avery, Anthony J.
Publicado 2020

Target occupancy study and whole-body dosimetry with a MAGL PET ligand [(11)C]PF-06809247 in non-human primates

por Arakawa, Ryosuke, Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Amini, Nahid, Maresca, Kevin P., Zhang, Lei, Keliher, Edmund J., Butler, Christopher R., Piro, Justin R., Samad, Tarek A., Smith, Deborah, Nason, Deane, O’Neil, Steve, Trapa, Patrick, Fonseca, Kari R., Litchfield, John, McCarthy, Timothy, Carson, Richard E., Halldin, Christer
Publicado 2022

Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study

por Tolaney, Sara M., Beeram, Muralidhar, Beck, J. Thaddeus, Conlin, Alison, Dees, E. Claire, Puhalla, Shannon L., Rexer, Brent N., Burris, Howard A., Jhaveri, Komal, Helsten, Teresa, Becerra, Carlos, Kalinsky, Kevin, Moore, Kathleen N., Manuel, Allison M., Lithio, Andrew, Price, Gregory L., Chapman, Sonya C., Litchfield, Lacey M., Goetz, Matthew P.
Publicado 2022