Mostrando 41 - 60 Resultados de 110,380 Para Buscar '"Lu'an"', tiempo de consulta: 1.01s Limitar resultados
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    “…Over the past few decades, several bone-seeking radiopharmaceuticals including various bisphosphonate ligands and β-emitting radionuclides have been developed for bone pain palliation. Recently, (177)Lu was successfully labeled with zoledronic acid ((177)Lu-ZLD) as a new generation potential bisphosphonate and demonstrated significant accumulation in bone tissue. …”
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  3. 43
    “…In this study, patients with significantly impaired baseline kidney function before initiation of therapy were investigated for treatment-associated nephrotoxicity and the potential relationship with administered activities of [(177)Lu]Lu-PSMA-617. Methods: Twenty-two mCRPC patients with impaired renal function (glomerular filtration rate (GFR) ≤ 60 mL/min) who received more than two cycles of [(177)Lu]Lu-PSMA-617 RLT (median 5 cycles and median 6-week time interval between consecutive cycles) were analyzed in this study. …”
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  4. 44
    “…Here, we investigate the influence that earlier cycles of [(177)Lu]Lu-DOTATATE had on the biokinetics and AD of subsequent cycles in a recent clinical trial that evaluated the safety and activity of [(177)Lu]Lu-DOTATATE in pediatric neuroblastoma (NBL). …”
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    por Hennrich, Ute, Eder, Matthias
    Publicado 2022
    “…In March 2022, [(177)Lu]Lu-PSMA-617 (Pluvicto(TM)) was approved by the FDA for the treatment of prostate cancer patients. …”
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  7. 47
    “…In this study, we investigated molecular imaging and biochemical responses after a single cycle of [(225)Ac]Ac-PSMA-617/[(177)Lu]Lu-PSMA-617 tandem therapy in patients who had progressed on [(177)Lu]Lu-PSMA-617 monotherapy. …”
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  8. 48
    “…The solubility of Lu within the system was found to be quite low with x(max) ∼ 0.3; samples with x > 0.3 contained impurities of LuSb. …”
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    “…BACKGROUND: In this work, a lutetium-177 ((177)Lu) production method based on the separation of nuclear isomers, (177m)Lu & (177)Lu, is reported. …”
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  11. 51
    “…BACKGROUND: Preclinical biodistribution and dosimetric analysis of [(177)Lu]Lu-DOTA(ZOL) suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. …”
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  12. 52
    “…The results highlighted some important quality issues of the final preparation: radiolabeling of PSMA-I&T with lutetium-177 needs a considerably longer time compared with the radiolabeling of the well-known [(177)Lu]Lu-PSMA-617. When the final product was formulated in saline, the stability of [(177)Lu]Lu-PSMA-I&T was reduced by radiolysis, showing a decrease in radiochemical purity (<95% in 24 h). …”
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  13. 53
    por Roig, O
    Publicado 2010
    “…The DANCE (Detector for Advanced Neutron Capture Experiments) array located at the Los Alamos national laboratory has been used to obtain the neutron capture cross sections for 175Lu and 176Lu with neutron energies from thermal up to 100 keV. …”
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    “…Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu(2)O(3 )sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). …”
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  20. 60
    “…PURPOSE: Lutetium Lu-177 dotatate is the first peptide receptor radionuclide therapy approved by the US Food and Drug Administration. …”
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