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41por Mitjavila, Mercedes, Jimenez-Fonseca, Paula, Belló, Pilar, Pubul, Virginia, Percovich, Juan Carlos, Garcia-Burillo, Amparo, Hernando, Jorge, Arbizu, Javier, Rodeño, Emilia, Estorch, Montserrat, Llana, Belén, Castellón, Maribel, García-Cañamaque, Lina, Gajate, Pablo, Riesco, Maria Carmen, Miguel, Maria Begoña, Balaguer-Muñoz, David, Custodio, Ana, Cano, Juana María, Repetto, Alexandra, Garcia-Alonso, Pilar, Muros, Maria Angustias, Vercher-Conejero, Jose Luis, Carmona-Bayonas, Alberto“…This study sought to elucidate the efficacy and safety of [(177)Lu]Lu-DOTATATE in NENs with different locations and evaluate the effect of the tumor origin, bearing in mind other prognostic variables. …”
Publicado 2023
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42“…Over the past few decades, several bone-seeking radiopharmaceuticals including various bisphosphonate ligands and β-emitting radionuclides have been developed for bone pain palliation. Recently, (177)Lu was successfully labeled with zoledronic acid ((177)Lu-ZLD) as a new generation potential bisphosphonate and demonstrated significant accumulation in bone tissue. …”
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43por Rosar, Florian, Kochems, Niklas, Bartholomä, Mark, Maus, Stephan, Stemler, Tobias, Linxweiler, Johannes, Khreish, Fadi, Ezziddin, Samer“…In this study, patients with significantly impaired baseline kidney function before initiation of therapy were investigated for treatment-associated nephrotoxicity and the potential relationship with administered activities of [(177)Lu]Lu-PSMA-617. Methods: Twenty-two mCRPC patients with impaired renal function (glomerular filtration rate (GFR) ≤ 60 mL/min) who received more than two cycles of [(177)Lu]Lu-PSMA-617 RLT (median 5 cycles and median 6-week time interval between consecutive cycles) were analyzed in this study. …”
Publicado 2021
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44por Malcolm, Javian C., Falzone, Nadia, Gains, Jennifer E., Aldridge, Matthew D., Mirando, David, Lee, Boon Q., Gaze, Mark N., Vallis, Katherine A.“…Here, we investigate the influence that earlier cycles of [(177)Lu]Lu-DOTATATE had on the biokinetics and AD of subsequent cycles in a recent clinical trial that evaluated the safety and activity of [(177)Lu]Lu-DOTATATE in pediatric neuroblastoma (NBL). …”
Publicado 2022
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45por Aalbersberg, Else A., Cao, Tammie T., Geluk-Jonker, Martine M., Hendrikx, Jeroen J. M. A.“…BACKGROUND: [(177)Lu]Lu-PSMA is used for the treatment of metastatic castration-resistant prostate cancer. …”
Publicado 2022
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46“…In March 2022, [(177)Lu]Lu-PSMA-617 (Pluvicto(TM)) was approved by the FDA for the treatment of prostate cancer patients. …”
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47por Rosar, Florian, Hau, Fabian, Bartholomä, Mark, Maus, Stephan, Stemler, Tobias, Linxweiler, Johannes, Ezziddin, Samer, Khreish, Fadi“…In this study, we investigated molecular imaging and biochemical responses after a single cycle of [(225)Ac]Ac-PSMA-617/[(177)Lu]Lu-PSMA-617 tandem therapy in patients who had progressed on [(177)Lu]Lu-PSMA-617 monotherapy. …”
Publicado 2021
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48“…The solubility of Lu within the system was found to be quite low with x(max) ∼ 0.3; samples with x > 0.3 contained impurities of LuSb. …”
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49por Riveira-Martin, Mercedes, Struelens, Lara, Muñoz Iglesias, José, Schoonjans, Werner, Tabuenca, Olga, Nogueiras, José Manuel, Salvador Gómez, Francisco Javier, López Medina, Antonio“…In recent years, [(177)Lu]Lu-DOTA-TATE has begun to be widely used for the treatment of neuroendocrine tumours. …”
Publicado 2023
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50por Bhardwaj, Rupali, Wolterbeek, Hubert Th., Denkova, Antonia G., Serra-Crespo, Pablo“…BACKGROUND: In this work, a lutetium-177 ((177)Lu) production method based on the separation of nuclear isomers, (177m)Lu & (177)Lu, is reported. …”
Publicado 2019
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51por Khawar, Ambreen, Eppard, Elisabeth, Roesch, Frank, Ahmadzadehfar, Hojjat, Kürpig, Stefan, Meisenheimer, Michael, Gaertner, Florian. C., Essler, Markus, Bundschuh, Ralph. A.“…BACKGROUND: Preclinical biodistribution and dosimetric analysis of [(177)Lu]Lu-DOTA(ZOL) suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. …”
Publicado 2019
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52por Di Iorio, Valentina, Boschi, Stefano, Cuni, Cristina, Monti, Manuela, Severi, Stefano, Paganelli, Giovanni, Masini, Carla“…The results highlighted some important quality issues of the final preparation: radiolabeling of PSMA-I&T with lutetium-177 needs a considerably longer time compared with the radiolabeling of the well-known [(177)Lu]Lu-PSMA-617. When the final product was formulated in saline, the stability of [(177)Lu]Lu-PSMA-I&T was reduced by radiolysis, showing a decrease in radiochemical purity (<95% in 24 h). …”
Publicado 2022
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53por Roig, O“…The DANCE (Detector for Advanced Neutron Capture Experiments) array located at the Los Alamos national laboratory has been used to obtain the neutron capture cross sections for 175Lu and 176Lu with neutron energies from thermal up to 100 keV. …”
Publicado 2010
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58por Lu, Chensheng, Toepel, Kathryn, Irish, Rene, Fenske, Richard A., Barr, Dana B., Bravo, RobertoEnlace del recurso
Publicado 2006
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59por Yousefnia, Hassan, Jalilian, Amir Reza, Bahrami-Samani, Ali, Mazidi, Mohammad, Ghannadi Maragheh, Mohammad, Abbasi-Davani, Fereydoun“…Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu(2)O(3 )sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). …”
Publicado 2013
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60por Salner, Andrew L., Blankenship, Bette, Dunnack, Hayley, Niemann, Christopher, Bertsch, Helaine“…PURPOSE: Lutetium Lu-177 dotatate is the first peptide receptor radionuclide therapy approved by the US Food and Drug Administration. …”
Publicado 2020
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