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  1. 461001
    “…Failed conservative management often leads arthroscopy and drilling of the lesion. …”
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    Trans-articular versus Retro-articular Drilling of Stable Osteochondritis Dissecans of the Knee: A Prospective Randomized Controlled Trial by the ROCK Multicenter Study Group
  2. 461002
    “…In addition, ruxolitinib has previously been shown to have potent activity against the cytokine response, similar to that seen in COVID-19 infections. The optimal management of patients on these agents who become infected with COVID-19 is unknown and it is not clear if the use of these agents modifies the clinical course of infection. …”
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    Outcomes of COVID-19 Infection in Patients Receiving Ruxolitinib and Hypomethylating Agent Therapy
  3. 461003
    “…Thachil, J., et al.,ISTH interim guidance on recognition and management of coagulopathy inCOVID-19.J Thromb Haemost, 2020.18(5): p. 1023-1026. 3. …”
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    COVID-19 Thrombosis: Understanding the Negative Predictive Value in a Pandemic
  4. 461004
    “…Conclusion:Our study demonstrated that there were similar processes but different intensity of inflammatory responses of sCRS in COVID-19 and CAR-T group. The diagnose and management of COVID-19 related sCRS can learn lessons from treatment of sCRS induced by CAR-T therapy. …”
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    Clinical Characterization and Risk Factors Associated with Cytokine Release Syndrome Induced By COVID-19 and Chimeric Antigen Receptor T-Cell Therapy
  5. 461005
    por Fatkhullin, Ramil, Shuvaev, Vasily
    Publicado 2020
    “…There is a need for guideline to thrombocytopenia management in COVID-19 patients. Now we are continuing to search and include the patients with COVID-19 infection and thrombocytopenia in our study. …”
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    Immune Thrombocytopenia Associated with COVID-19 - Case Series
  6. 461006
    “…The expression of both pri-miRNAs was significantly high in ER-positive and HER2-negative subgroups of BC; hence, these biomarkers might play a role in the management of endocrine therapy designs. Additionally, with a case–control cohort study, we identified that high expression of pri-miR526b in the blood is also a risk factor associated with breast cancer (OR = 4.3, CI = 1.39–13.34, p = 0.01). …”
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    Pri-miR526b and Pri-miR655 Are Potential Blood Biomarkers for Breast Cancer
  7. 461007
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    A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies
  8. 461008
    “…Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management. FUNDING: This work is supported by UCL Queen Square Biomedical Research Centre (BRC) and Moorfields BRC grants (#560441 and #557595). …”
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    Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study
  9. 461009
    “…For the latter, the risk management plans no longer contain important risks, considered important safety concerns, on the basis that routine pharmacovigilance activity would not allow their further characterisation. …”
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    Monitoring the manufacturing and quality of medicines: a fundamental task of pharmacovigilance
  10. 461010
    “…In the era of SLNB and precision medicine, the combined application of genomic tests and SLNB could provide patients with a better strategy of dual de-escalation management, including the de-escalation of both surgery and systemic treatment.…”
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    Candidates of Genomic Tests in HR+/HER2- Breast Cancer Patients With 1-2 Positive Sentinel Lymph Node Without Axillary Lymph Node Dissection: Analysis From Multicentric Cohorts
  11. 461011
    “…No excessive rises in BP were recorded in individuals, but antihypertensive medications were reintroduced during total diet replacement to manage raised BP for 19/69 (27.5%) participants, mostly within the first 3–7 weeks, despite some weight loss. …”
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    Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)
  12. 461012
    “…Furthermore, understanding the interaction between these risk factors may help better interventions in controlling the disease, reducing the costs related to disease management, further implications for clinical practice and research approaches in addition to improving patients’ mental health and quality of life.…”
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    A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration
  13. 461013
    “…IMPORTANCE: The inclusion of digital therapeutics (eg, virtual reality [VR] systems) for the management of pain and anxiety associated with routine acutely painful medical procedures may have a substantial impact on treatment adherence and improve long-term health outcomes among young patients. …”
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    Effect of an Immersive Virtual Reality Intervention on Pain and Anxiety Associated With Peripheral Intravenous Catheter Placement in the Pediatric Setting: A Randomized Clinical Trial
  14. 461014
    “…SIMPLE SUMMARY: Managing aquatic systems is becoming increasingly complex due to human impacts, multiple and competing water needs and climate variability. …”
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    Chronological Trends and Mercury Bioaccumulation in an Aquatic Semiarid Ecosystem under a Global Climate Change Scenario in the Northeastern Coast of Brazil
  15. 461015
    Publicado 2021
    “…Preventive measures such as smoking control interventions, air quality management programmes focused on major air pollution sources, and widespread access to clean energy should be prioritised in these settings. …”
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    Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019
  16. 461016
    “…CONCLUSIONS: Vaccine hesitancy is common (10-20%) in pwMS, consequent to insufficient knowledge and misconceptions about vaccination among pwMS and suboptimal vaccine promotion by healthcare professionals who manage pwMS. Conscientious and context-specific vaccination counselling is necessary to tackle vaccine hesitancy among pwMS, including (i) avoiding infection-associated disability accrual during MS relapses, (ii) reducing the potentially higher risk of life-threatening/treatment-refractory complications that may be observed in those who develop vaccine-preventable infections while receiving certain DMTs, and (iii) avoiding attenuated vaccine responses or delayed/interrupted DMT with early pre-treatment vaccine delivery where possible.…”
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    Vaccine hesitancy among people with multiple sclerosis
  17. 461017
    “…BACKGROUND: The use of the internet and web-based platforms to obtain public health information and manage health-related issues has become widespread in this digital age. …”
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    Association Between What People Learned About COVID-19 Using Web Searches and Their Behavior Toward Public Health Guidelines: Empirical Infodemiology Study
  18. 461018
    “…ICOPE might be usefully integrated into community programmes for detecting and case managing chronic diseases including hypertension and diabetes.…”
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    Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohort study
  19. 461019
    “…Malnutrition of PDAC patients is known to be associated with poor prognosis; therefore, nutritional management during chemotherapy is a key factor influencing the outcome of the treatment. …”
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    Usefulness of Smartphone Apps for Improving Nutritional Status of Pancreatic Cancer Patients: Randomized Controlled Trial
  20. 461020
    “…This will aid the diagnosis and management of co-infected patients in endemic areas. …”
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    Prevalence of malaria and scrub typhus co-infection in febrile patients: a systematic review and meta-analysis
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