MODL-28. IMMUNE PRIMING WITH INTERFERON-Γ COMBINED WITH EPIGENETIC MODULATION IN PEDIATRIC BRAIN TUMORS

por Crotty, Erin, Morris, Shelli, Brasel, Ken, Girard, Emily, Noll, Alyssa, Mhyre, Andrew, Olson, James
Publicado 2020

MODL-28. Patient-derived, three-dimensional organoid platform for pediatric brain tumor modeling

por Baubet, Valerie, Beale, David, Mariarita, Santi, Viaene, Angela, Madsen, Peter, Jacob, Fadi, Ming, Guo-li, Hongjun, Song, Phillip, Storm, Koptyra, Mateusz, Adam, Resnick
Publicado 2022

MODL-03. Establishment of intraventricular Shh inhibition as a therapeutic option for young patients with medulloblastoma

por Kresbach, Catena, Schoof, Melanie, Holst, Lea, Leven, Tara, Yorgan, Timur, Wrzeszcz, Antonina, Rutkowski, Stefan, Schüller, Ulrich
Publicado 2022

MODL-22. DEVELOPING A REAL-TIME PERSONALIZED DRUG TESTING PLATFORM FOR PEDIATRIC CNS CANCERS

por Laternser, Sandra, Cosentino, Chiara Cianciolo, Przystal, Justyna M, Dettwiler, Susanne, Rushing, Elisabeth Jane, Gerber, Nicolas U, Stücklin, Ana Guerreiro, Prasad, Rachna, Grotzer, Michael, Krayenbühl, Niklaus, Müller, Sabine, Nazarian, Javad
Publicado 2020

OLOGRAM-MODL: mining enriched n-wise combinations of genomic features with Monte Carlo and dictionary learning

por Ferré, Quentin, Capponi, Cécile, Puthier, Denis
Publicado 2021

MODL-04. Drug screening in Disorders with Abnormal DNA Damage Response/Repair (DADDR) andin vivo validation

por Kolodziejczak, Anna, Selt, Florian, Peterziel, Heike, Jamaladdin, Nora, Mack, Norman, Maass, Kendra, Kool, Marcel, Herold-Mende, Christel, El Damaty, Ahmed, Oehme, Ina, Jones, David T W, Witt, Olaf, Pajtler, Kristian W, Kratz, Christian, Pfister, Stefan M, Milde, Till
Publicado 2022

MODL-05 Metronomic Intrathecal Delivery of CDK4/6 Inhibitors in Preclinical Models of Pediatric Brain Tumors

por Guadix, Sergio, Martin, Brice, Laramee, Madeline, Dahmane, Nadia, Thomas, Craig, Souweidane, Mark
Publicado 2022

MODL-06. Targeting c-MET in combination with radiation is effective in MET-fusion driven high-grade glioma

por Zuckermann, Marc, He, Chen, Andrews, Jared, Sloan-Henry, Roketa, Bianski, Brandon, Xie, Jia, Wang, Yingzhe, Twarog, Nathaniel, Onar-Thomas, Arzu, Ernst, Kati, Yang, Lei, Li, Yong, Dalton, James, Li, Xiaoyu, Chepyala, Divyabharathi, Zhu, Xiaoyan, Zhang, Junyuan, Xu, Ke, Hover, Laura, McKinnon, Peter J, Pfister, Stefan M, Rankovic, Zoran, Freeman, Burgess B, Shelat, Anang A, Chiang, Jason, Jones, David T W, Tinkle, Christopher L, Baker, Suzanne J
Publicado 2022

MODL-23. DNA METHYLATION AND COPY NUMBER VARIATION PROFILE FOR CHARACTERIZATION OF PEDIATRIC BRAIN TUMOR PRIMARY CELL LINES

por Pedace, Lucia, Vinci, Maria, Pizzi, Simone, Pericoli, Giulia, Catanzaro, Giuseppina, Abballe, Luana, Del Bufalo, Francesca, Caruana, Ignazio, Camassei, Francesca Diomedi, Rossi, Sabrina, Giangaspero, Felice, Ferretti, Elisabetta, Ciolfi, Andrea, Tartaglia, Marco, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina
Publicado 2020

MODL-24. AN ORGANOTYPIC CHUNK CULTURE TECHNIQUE TO STUDY DISEASE MECHANISM AND DEVELOP TARGETED THERAPEUTICS FOR PEDIATRIC ADAMANTINOMATOUS CRANIOPHARYNGIOMA

por Vijmasi, Trinka, Prince, Eric, Hengartner, Astrid, Staulcup, Susan, Griesinger, Andrea, Donson, Andrew, Gilani, Ahmed, Foreman, Nicholas, Hankinson, Todd
Publicado 2020

MODL-27. MEK INHIBITION WITH TRAMETINIB SLOWS PROGRESSION OF MEDULLOBLASTOMA AND ATYPICAL TERATOID RHABDOID TUMOR IN ORTHOTOPIC XENOGRAFT MURINE MODEL

por Mushrif, Sujata, Hung, Long, Muthugounder, Sakunthala, Asgharzadeh, Shahab
Publicado 2020

MODL-25. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS, MECHANISMS OF IMMUNE EVASION, AND COMBINATORIAL IMMUNOTHERAPY

por Galati, Melissa, Li, Li, Sudhaman, Sumedha, Lipman, Tatiana, Stengs, Lucie, Elshaer, Dana, Bridge, Taylor, Semenova, Dar’ya, Edwards, Melissa, Hodel, Karl, Forster, Victoria J, Nunes, Nuno M, Martin, Alberto, Bouffet, Eric, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri
Publicado 2020

MODL-19. DIPG HARBOUR ALTERATIONS TARGETABLE BY MEK INHIBITORS, WITH ACQUIRED RESISTANCE MECHANISMS OVERCOME BY COMBINATORIAL UP- OR DOWN-STREAM INHIBITION

por Izquierdo, Elisa, Carvalho, Diana, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Molinari, Valeria, Stubbs, Mark, Depani, Sarita, O’Hare, Patricia, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris
Publicado 2020

MODL-16. ABEMACICLIB, A SELECTIVE CDK4/6 INHIBITOR, RESTRICTS GROWTH OF PEDIATRIC GLIAL-LINEAGE TUMORS IN VITRO AND IN VIVO

por Liang, Muh-Lii, Hsieh, Tsung-Han, Wong, Tai-Tong
Publicado 2020

MODL-31. Novel in vivo models of post-radiation recurrent pediatric high-grade glioma show increased susceptibility to MAPK inhibition

por Knox, Aaron, DeSisto, John, Nelson-Taylor, Sarah, Coleman, Philip, Van Court, Benjamin, Donson, Andrew, Karam, Sana, Green, Adam
Publicado 2022

MODL-02. A novelCre-conditionalcMYC-driven MB Group 3 transgenic mouse model shows traceable leptomeningeal dissemination.

por Morcavallo, Alaide, Barker, Karen, Kwok, Colin, Boult, Jessica K R, da Silva, Patricia Benites Goncalves, Okonechnikov, Konstantin, Zuckermann, Marc, Gorrini, Chiara, Jacques, Thomas S, Robinson, Simon P, Clifford, Steven C, Weiss, William A, Pfister, Stefan M, Kawauchi, Daisuke, Chesler, Louis
Publicado 2022

MODL-20. A BIOBANK OF ~100 PATIENT-DERIVED MODELS REPRESENTING BIOLOGICAL HETEROGENEITY AND DISTINCT THERAPEUTIC DEPENDENCIES IN PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

por Carvalho, Diana, Mackay, Alan, Temelso, Sara, Izquierdo, Elisa, Fernandez, Elisabet Potente, Rogers, Rebecca, Boult, Jessica, Salom, Janat Fazal, Simon, Natalie, Clarke, Matthew, Molinari, Valeria, Kessler, Ketty, Burford, Anna, Bjerke, Lynn, Fofana, Mariama, Hubank, Michael, Pears, Jane, Moore, Andrew, Carcaboso, Angel Montero, Marshall, Lynley, Carceller, Fernando, Robinson, Simon, Hargrave, Darren, Vinci, Maria, Jones, Chris
Publicado 2020

MODL-31. RADIATION-DERIVED TREATMENT-RESISTANT PDX AND CELL CULTURE MODELS RECAPITULATE THE CHARACTERISTICS OF MATCHED PRIMARY/RECURRENT PEDIATRIC HIGH-GRADE GLIOMA

por Knox, Aaron J, Flannery, Patrick, Zukosky, Anjali, DeSisto, John, Sanford, Bridget, van Court, Benjamin, Donson, Andrew, Lemma, Rakeb, Chatwin, Hannah, Karam, Sana D, Vibhakar, Rajeev, Jones, Ken, Green, Adam L
Publicado 2020

MODL-09. FEASIBILITY OF ACUTE SLICE CULTURE-SINGLE CELL SEQUENCING DRUG SCREENING AS A TOOL TO SELECT THERAPY FOR CHILDREN WITH RELAPSED BRAIN TUMORS

por Gampel, Bradley, Szalontay, Luca, Zhao, Wenting, Garvin, James, Sethi, Chankrit, Stark, Eileen, Sims, Peter, Canoll, Peter, Zacharoulis, Stergios
Publicado 2020

MODL-27. An organotypic brain slice culture platform as a novel pre-clinical model for diffuse intrinsic pontine glioma and diffuse midline glioma

por Mann, Breanna, Zhang, Xiaopei, Bell, Noah, Adefolaju, Adebimpe, Dasari, Rajaneekar, Valdivia, Alain, Buckley, Andrew, Quinsey, Carolyn, Hingtgen, Shawn, Satterlee, Andrew
Publicado 2022