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  1. 421
    “…As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m(6)A) has been shown to possess important post-transcriptional regulatory functions. …”
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    Online Artículo Texto
    m(6)A-Driver: Identifying Context-Specific mRNA m(6)A Methylation-Driven Gene Interaction Networks
  2. 422
    “…Understanding the biologic role of N(6)-methyladenosine (m(6)A) RNA modifications in mRNA requires an understanding of when and where in the life of a pre-mRNA transcript the modifications are made. …”
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    m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
  3. 423
    “…Our study identified the characteristics of m(1)A‐, m(5)C‐ and m(6)A‐related regulators based on 468 CM samples from the public database. …”
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    Online Artículo Texto
    Prognostic signature and immune efficacy of m(1)A‐, m(5)C‐ and m(6)A‐related regulators in cutaneous melanoma
  4. 424
    “…This study was performed to explore the effectiveness of an mRNA-based therapeutic strategy using in vitro synthesized PTEN-mRNA and TRAIL-mRNA in tumor cells derived from PTEN-deletion patients. …”
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    Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy
  5. 425
    “…The mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer (TC). …”
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    mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 and mTORC2 Complexes for Tumor Behavior and SLC5A5 mRNA Expression
  6. 426
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    Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m(6)A, m(5)C, m(3)U, and m(5)U by top-down mass spectrometry
  7. 427
    “…RESULTS: HupA caused pupil constriction in a dose-time dependent manner which was reversed by the nonselective muscarinic acetylcholine receptor (mAChR) antagonist atropine and the selective M3 mAChR antagonist 4-DAMP. …”
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    Huperzine A lowers intraocular pressure via the M3 mAChR and provides retinal neuroprotection via the M1 mAChR: a promising agent for the treatment of glaucoma
  8. 428
    “…Expression analysis revealed that the m6A levels did not affect m6A mRNA or m6A circRNA expression. …”
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    Online Artículo Texto
    Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons
  9. 429
    “…Results: Our study developed a reliable AAA-related disease model for predicting immunity and m1A/m5C/m6A/m7G epigenetic regulation. Discussion: The pathogenic roles of four model genes, UBE2K, TMEM230, VAMP7, and PUM2, in AAA, need further validation by in vitro and in vivo experiments.…”
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    The abdominal aortic aneurysm-related disease model based on machine learning predicts immunity and m1A/m5C/m6A/m7G epigenetic regulation
  10. 430
    por Kölbig, Kurt Siegfried
    Publicado 1981
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    A program for computing the conical functions of the first kind $P^{m}_{-1/2+i\tau}(x)$ for $m = 0$ and $m = 1$
  11. 431
    “…The deduced magnetic moments are $\mu( ^{68}$Cu$^{g}$, I$^{\pi}$ = 1$^+$) = +2.48(2)(7)$\mu_{N}$ ; $\mu(^{68}$Cu$^{m}$, I$^{\pi}$=6$^{-}$) = +1.24(4)(6)$\mu_{N}$ and $\mu(^{70}$Cu$^{m_{2}}$, I$^{\pi}$=1$^{+}$) = +1.86(4)(6)$\mu_{N}$ ; $\mu(^{70}$Cu$^{g}$, I$^{\pi}$=6$^{-}$) = +1.50(7)(8)$\mu_{N}$. …”
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    Magnetic moments of $^{68}$Cu$^{g,m}$ and $^{70}$Cu$^{g,m_{1},m_{2}}$ nuclei measured by in-source laser spectroscopy
  12. 432
    “…Amphetamine dose-dependently induced USVs in wild-type males (most at 0.5 mg/kg i.p.), but did not elicit USVs in M5 KO or female mice. These studies suggest that M2 and M5 muscarinic receptors are needed for male USV production during male-female interactions, likely via their roles in dopamine activation. …”
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    Ultrasonic Vocalizations Induced by Sex and Amphetamine in M2, M4, M5 Muscarinic and D2 Dopamine Receptor Knockout Mice
  13. 433
    Publicado 1934
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    Andrew Fullerton, C.B., C.M.G., M.D., M.CH., F.R.C.S.I., F.A.C.S
  14. 434
    “…[Image: see text] The copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) click reaction was used to incorporate alkyne-functionalized dipicolylamine (DPA) ligands (1 and 3) for fac-[M(I)(CO)(3)](+) (M = Re/(99m)Tc) complexation into an α-melanocyte stimulating hormone (α-MSH) peptide analogue. …”
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    Clickable, Hydrophilic Ligand for fac-[M(I)(CO)(3)](+) (M = Re/(99m)Tc) Applied in an S-Functionalized α-MSH Peptide
  15. 435
    “…OPN additionally modulated the quantity of microglia subpopulations, reducing iNOS+ M1 cells while increasing M2 microglia, shifting the M1/M2 balance towards an M2 phenotype. …”
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    Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia
  16. 436
    “…Pre-treating the Asp with leucine aminopeptidase inhibitor and the specific antibodies of Acanthamoeba M20/M25/M40 superfamily aminopeptidase could reduce the cell damage during Asp and cell co-incubation. …”
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    Pathogenic Acanthamoeba castellanii Secretes the Extracellular Aminopeptidase M20/M25/M40 Family Protein to Target Cells for Phagocytosis by Disruption
  17. 437
    “…Mice were immunized with recombinant Sse of M1 GAS (Sse(M1)) and challenged with MGAS5005 (serotype M1, CovS mutant, and Sse of variant complex I), MGAS315 (M3, CovS mutant, and Sse of variant complex I), MGAS2221 (M1, wild-type CovRS, and Sse of variant complex I), and MGAS6180 (M28, wild-type CovRS, and Sse of variant complex II). …”
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    Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus
  18. 438
    “…BACKGROUND: Different phenotypes of macrophages (M0, M1 and M2 Mφs) have been demonstrated to play distinct roles in regulating mesenchymal stem cells in various in vitro and in vivo systems. …”
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    Exosomes derived from M0, M1 and M2 macrophages exert distinct influences on the proliferation and differentiation of mesenchymal stem cells
  19. 439
    “…In accordance with new molecular and morphological data, we suggest taxonomic reappraisal of M. pseudopaedida and M. robertiana, and M. fontenlae and M. acystidiata are proposed as new species. …”
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    Melanoleuca galbuserae, M. fontenlae and M. acystidiata—Three New Species in Subgenus Urticocystis (Pluteaceae, Basidiomycota) with Comments on M. castaneofusca and Related Species
  20. 440
    “…mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1. …”
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    RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
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