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  1. 461
    por Kang, Diana D., Li, Haoyuan, Dong, Yizhou
    Publicado 2023
    “…The accelerated progress and approval of two mRNA-based vaccines to address the SARS-CoV-2 virus were unprecedented. …”
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    Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
  2. 462
    “…It is well known that undifferentiated macrophages can polarize into classically activated macrophages (M1 macrophages) and alternatively activated macrophages (M2 macrophages) under different microenvironmental conditions. …”
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    Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases
  3. 463
    “…PMEs specifically demethylates m6A of targeted mRNAs (WUS, STM, FT, SPL3 and SPL9) to increase mRNAs stability. …”
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    Targeted mRNA demethylation in Arabidopsis using plant m6A editor
  4. 464
    “…N6-methyladenosine (m(6)A) is a dynamic and reversible epigenetic regulation. …”
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    Decoding m(6)A mRNA methylation by reader proteins in liver diseases
  5. 465
    “…Additionally, neutrophils were cultured in the presence of natural killer (NK) cells, regulatory T cells (Tregs), pro-inflammatory or anti-inflammatory macrophages (M1 or M2 macrophages), or in the presence of NK/Tregs/M1 macrophages or M2 macrophages-conditioned medium and subsequently stimulated to release NETs. …”
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    Secretomes of M1 and M2 macrophages decrease the release of neutrophil extracellular traps
  6. 466
    “…TAM is divided into tumor-suppressive M1-like (classic activation of macrophages) and tumor-supportive M2-like (alternatively activated macrophages) polarized cells. …”
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    The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets
  7. 467
    Publicado 1975
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    Obituary: Vincent Zachary Cope, Kt., M.D., M.S., F.R.C.S.
  8. 468
    “…RESULTS: In wild type MEF cells transiently expressing M(2 )mAChRs, 40% of surface M(2 )mAChRs underwent internalization and sorted into intracellular compartments following agonist stimulation. …”
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    Agonist mediated internalization of M(2 )mAChR is β-arrestin-dependent
  9. 469
    “…These results suggest that the thermodynamic stability of DNA/DNA and mRNA/DNA duplexes affects mRNA transcription.…”
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    Stability of mRNA/DNA and DNA/DNA Duplexes Affects mRNA Transcription
  10. 470
    Publicado 1934
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    Sir William Whitla, M.A., M.D., D.SC., LL.D
  11. 471
    por Mitchell, A. B.
    Publicado 1934
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    Sir William Whitla, M.A., M.D., D.SC., LL.D
  12. 472
    “…The mTOR Complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses(1). mTORC1 regulates mRNA translation, but the overall translational program is poorly defined and no unifying model exists to explain how mTORC1 differentially controls the translation of specific mRNAs. …”
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    A unifying model for mTORC1-mediated regulation of mRNA translation
  13. 473
    por Jansen, Ralf-Peter, Niessing, Dierk
    Publicado 2012
    “…The first example is She2p/She3p-dependent localization of ASH1 mRNA in budding yeast. It is particularly well suited to highlight the interdependence between different steps of mRNA localization. …”
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    Assembly of mRNA-Protein Complexes for Directional mRNA Transport in Eukaryotes - An Overview
  14. 474
    “…DEBATE: The conjunction of high levels of mental illness and high levels of mobile phone usage in poorer countries highlights the potential for “mH(2)” interventions – i.e. mHealth (mobile technology-based) mental health interventions - to tackle global mental health challenges. …”
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    mHealth and global mental health: still waiting for the mH(2) wedding?
  15. 475
    “…Influenza transcription results in spliced mRNAs (M2 and NS2), intron-containing mRNAs (M1 and NS1), and intron-less mRNAs (HA, NA, NP, PB1, PB2, and PA), all of which undergo nuclear export into the cytoplasm for translation. …”
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    Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export
  16. 476
    por Italiani, Paola, Boraschi, Diana
    Publicado 2014
    “…When monocytes differentiate into macrophages in a tissue (concomitantly adopting a specific functional program, M1 or M2), do they all die during the inflammatory reaction, or do some of them survive? …”
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    From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
  17. 477
    “…mTOR is a central controller for cell growth/proliferation and survival. …”
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    Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
  18. 478
    “…Macrophages in a tumor microenvironment have been characterized as M1- and M2-polarized subtypes. Here, we discovered the different macrophages’ impacts on lung cancer cell A549. …”
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    Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression
  19. 479
    “…The RD-histone mRNAs are the only known cellular mRNAs that are not polyadenylated. …”
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    A multiprotein occupancy map of the mRNP on the 3′ end of histone mRNAs
  20. 480
    “…Among these agents, first generation mTOR inhibitors (rapalogs) have caused responses in so-called “N-of-1” cases and second generation mTOR kinase inhibitors (TORKi) are currently in clinical trials(2–4). …”
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    Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
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