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“…M1 and M2 macrophage-type responses kill or repair in vivo. …”
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“…Initial studies with viruses paved the way to discover the 5′-cap m(7)GpppNm structure present generally in cellular mRNAs of eukaryotes. …”
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“…As a next step in directing the pro-inflammatory response toward the anti-inflammatory type after an insult by a foreign pathogen (e. g., bacterial lipopolysaccharide), investigators have identified many natural compounds that have the potential to modulate M1 to M2 macrophages. In this review, we provide a focused discussion of advances in the identification of natural therapeutic molecules with anti-inflammatory properties that modulate the phenotype of macrophages from M1 to M2.…”
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“…The aim of this study was to determine the effect of an altitude of 2250 m on the time for a 100-m sprint. Competition results from the 13 Olympic Games between 1964 and 2012 were corrected for the effects of wind and de-trended for the historical improvement in performance. …”
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“…During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. …”
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“…The mechanistic target of rapamycin (mTOR) has gathered significant attention as a ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation, and survival. …”
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“…There are two main ways of mRNA vaccine delivery for this: ex vivo loading of mRNA into dendritic cells (DCs) and direct injection of mRNA with or without a carrier. …”
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“…RESULTS: The results clearly revealed a high homology between M. pilosus and M. ruber, and their distant relationship with M. purpureus. …”
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“…Materials and methods: An m(6)A mRNA epitranscriptomic microarray analysis was performed to analyze m(6)A modification patterns in middle ear cholesteatoma tissue (n = 5) and normal post-auricular skin samples (n = 5). …”
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“…We characterized rabbit macrophages that were polarized using human recombinant GM‐CSF and M‐CSF. GM‐CSF‐treated macrophages had higher mRNA expression of proinflammatory cytokines (M1 phenotype) than did the M‐CSF‐treated counterpart. …”
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“…The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). …”
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“…The process of translation initiation in prokaryotes is mediated by the hybridization of the 16S rRNA of the small ribosomal subunit with the mRNA in a short region called the ribosomal binding site. …”
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“…However, it is unknown which type of MΦ, M1 or M2, plays a more essential role in the ovary. …”
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“…Lowest cerebral glutamate was measured at brain glucose 3-5 mM with a significant increase at brain glucose below 3 mM and above 6 mM. …”
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