Mostrando 21 - 40 Resultados de 110 Para Buscar '"MC5"', tiempo de consulta: 2.39s Limitar resultados
  1. 21
    “…This post-EAU regulatory immunity requires a melanocortin 5 receptor (MC5r)-dependent suppressor antigen presenting cell (APC), as shown using a MC5r single knock-out mouse. …”
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    Combined Deficiency of the Melanocortin 5 Receptor and Adenosine 2A Receptor Unexpectedly Provides Resistance to Autoimmune Disease in a CD8(+) T Cell-Dependent Manner
  2. 22
    “…ERK, STAT5, and AKT phosphorylation was inhibited by blocking MC2R, MC1R, and MC5R, respectively. Finally, the phosphorylation of myosin light chain 2, which is essential for the formation of contractile actomyosin rings, was inhibited by anti-MC5R nAb. …”
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    Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1, 2 and 5
  3. 23
    “…We showed, by a molecular modeling approach, that fingolimod can bind with good-predicted affinity to MC1R and MC5R. Thereafter, we investigated the fingolimod actions on retinal MC1Rs/MC5Rs in C57BL/6J mice. …”
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    Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study
  4. 24
    “…CONCLUSION: When developing an anti-obesity therapeutic drug with selective MC4R/MC5R properties, effects on lipolysis in white adipose tissue may be physiologically relevant.…”
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    Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
  5. 25
    por Switonski, M., Mankowska, M., Salamon, S.
    Publicado 2013
    “…Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R. …”
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    Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects
  6. 26
    “…Three melanocortin receptor genes (MC1R, MC2R, and MC5R) contribute to the risk of major depressive disorder (MDD), and one melanocortin receptor gene (MC4R) contributes to the risk of type 2 diabetes (T2D). …”
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    Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression
  7. 27
    “…Specific inhibition of MC2R and MC5R expression with short interfering Mc2r and Mc5r RNAs significantly attenuated the α-MSH-induced increase of intracellular cAMP and both the level of Il6 mRNA and secretion of IL6 in 3T3-L1 adipocytes. …”
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    Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes
  8. 28
    “…Those were 1.63 (mc4-3) to 2.59 (mc4-1) for ST depression, and 1.54 (mc5-3) to 2.33 (mc5-1) for T abnormality. The lower the second number of the Minnesota Codes was, the higher hazard ratio was observed in the Q-QS, ST, T codes. …”
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    A Nineteen-Year Cohort Study on the Relationship of Electrocardiographic Findings to All Cause Mortality Among Subjects in The National Survey on Circulatory Disorders, NIPPON DATA80.
  9. 29
    “…They included six flavonoids, 5-hydroxy-4′,7-dimethoxyflavanone (C1), matteucinol (C2), isosakuranetin (C3), 5,7- dimethoxyflavanone (C4), 2′,4′-dihydroxy-6′-methoxydihydrochalcone (in MC5) and alpinetin (C10), and seven kavalactones, 5,6-dehydrokawain (DK) (in MC5 and C6), kavain (in MC7), yangonin (in MC7 and C8), dihydro-5,6-dehydrokavain (DDK) (in MC9), 7,8-dihydromethysticin (in MC9), dihydromethysticin (in MC9), methysticin (in MC9). …”
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    Isolation and Identification of Constituents Exhibiting Antioxidant, Antibacterial, and Antihyperuricemia Activities in Piper methysticum Root
  10. 30
    “…Here, we report three cryo-electron microscopy structures of MC3R–G(s) in complex with γ-MSH and MC5R–G(s) in the presence of α-MSH or a potent synthetic agonist PG-901. …”
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    Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
  11. 31
    “…CONCLUSION: These data describe a novel endocrine circuit that modulates glucose homeostasis by pituitary α-MSH, which increases muscle glucose uptake and thermogenesis through the activation of a MC5R-PKA-pathway, which is disrupted in obesity.…”
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    α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
  12. 32
    “…The genome of S. meliloti MC5–2 was sequenced, and gene mutations were identified and analyzed. …”
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    Engineering a vitamin B(12) high-throughput screening system by riboswitch sensor in Sinorhizobium meliloti
  13. 33
    por Dores, Robert M.
    Publicado 2013
    “…The presence of five genes in the family (i.e., mc1r, mc2r, mc3r, mc4r, mc5r) in representatives of the tetrapods indicates that the gene family is the result of two genome duplication events and one local gene duplication event during the evolution of the chordates. …”
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    Observations on the Evolution of the Melanocortin Receptor Gene Family: Distinctive Features of the Melanocortin-2 Receptor
  14. 34
    por Dores, Robert M.
    Publicado 2016
    “…Finally, the origin of the mc2r and mc5r genes is reevaluated. The distinctive primary sequence conservation of MC2R and MC5R is discussed in light of the physiological roles of these two MCR paralogs.…”
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    Hypothesis and Theory: Revisiting Views on the Co-evolution of the Melanocortin Receptors and the Accessory Proteins, MRAP1 and MRAP2
  15. 35
    “…CONCLUSIONS: Along with already published biological evidence, MC5R, DYM and NEDD4L make attractive candidates for dyslexia susceptibility genes. …”
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    Identification of Candidate Genes for Dyslexia Susceptibility on Chromosome 18
  16. 36
    “…Can you perform a robust histopathological diagnosis for this unusual case? 
http://ow.ly/40GB30mc5Th…”
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    An uncommon histopathological diagnosis
  17. 37
    “…We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods:The test compound or solvent was injected subcutaneously to mice, for 7 days. …”
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    Differential Metabolic Effects of Novel Cilostamide Analogs, Methyl Carbostiryl Derivatives, on Mouse and Hyperglycemic Rat
  18. 38
    “…Moreover, B. subtilis Co1-6 and P. polymyxa Mc5Re-14 showed an enhancement of the bioactive secondary metabolite apigenin-7-O-glucoside. …”
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    Effects of bacterial inoculants on the indigenous microbiome and secondary metabolites of chamomile plants
  19. 39
    “…Foxo4 was found as a negative regulator for MC5R transcription in αMSH inhibited inflammation. …”
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    αMSH inhibits adipose inflammation via reducing FoxOs transcription and blocking Akt/JNK pathway in mice
  20. 40
    “…All three MC peptides stimulated calcium response in cells co-transfected with GPR139 and MC3R, MC4R, or MC5R. The MC peptides did not stimulate calcium response in cells expressing MC3R or MC5R alone consistent with the G(s) signaling transduction pathway of these receptors. …”
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    Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro
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